Hemostatic abnormalities in inflammatory bowel disease
Patients affected by inflammatory bowel disease (IBD) frequently suffer from thromboembolic events. Aims of this study were to investigate hemostatic system and the presence of antiphospholipid antibodies (aPL) in IBD patients. Forty-one patients affected by Crohn's disease (CD) and 19 by ulcer...
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| Veröffentlicht in: | Thrombosis research 1996-04, Vol.82 (2), p.137-146 |
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| creator | Chiarantini, Elena Valanzano, Rosa Liotta, Agatina Alessandrello Cellai, Anna Paola Fedi, Sandra Ilari, Isabella Prisco, Demenico Tonelli, Francesco Abbate, Rosanna |
| description | Patients affected by inflammatory bowel disease (IBD) frequently suffer from thromboembolic events. Aims of this study were to investigate hemostatic system and the presence of antiphospholipid antibodies (aPL) in IBD patients. Forty-one patients affected by Crohn's disease (CD) and 19 by ulcerative colitis (UC) were studied, compared to 40 healthy control subjects. platelet count (PLT), PT, aPTT, fibrinogen (Fib), prothrombin fragment F1+2, antithrombin (AT), protein C (PC), protein S (PS), factor XIII (FXIII), plasminogen (PLG), plasminogen activator inhibitor (PAI), spontaneous platelet aggregation in platelet-rich plasma (PRP-SPA) and in whole blood (WB-SPA), and antiphospholipid antibodies (aPL) were evaluated. PLT, Fib, F1+2 and WB-SPA were significantly increased in IBD patients (p at least |
| doi_str_mv | 10.1016/0049-3848(96)00060-6 |
| format | Article |
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Aims of this study were to investigate hemostatic system and the presence of antiphospholipid antibodies (aPL) in IBD patients. Forty-one patients affected by Crohn's disease (CD) and 19 by ulcerative colitis (UC) were studied, compared to 40 healthy control subjects. platelet count (PLT), PT, aPTT, fibrinogen (Fib), prothrombin fragment F1+2, antithrombin (AT), protein C (PC), protein S (PS), factor XIII (FXIII), plasminogen (PLG), plasminogen activator inhibitor (PAI), spontaneous platelet aggregation in platelet-rich plasma (PRP-SPA) and in whole blood (WB-SPA), and antiphospholipid antibodies (aPL) were evaluated. PLT, Fib, F1+2 and WB-SPA were significantly increased in IBD patients (p at least <0.05) both in active and inactive phases; aPL positivity was more frequent (p<0.05) and FXIII was significantly decreased (p<0.05) in comparison to control subjects. The thrombophilic state of IBD patients is not related to the degree of activity of the disease or to previous thrombotic events; aPL express the immunological alterations connected with IBD and are not the main cause of thrombotic events.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(96)00060-6</identifier><identifier>PMID: 9163067</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Antiphospholipid - blood ; Biological and medical sciences ; Blood Coagulation - immunology ; coagulation ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - immunology ; Crohn Disease - blood ; Crohn Disease - complications ; Crohn Disease - immunology ; Crohn's disease ; Female ; fibrinolysis ; Gastroenterology. Liver. Pancreas. Abdomen ; Hemostasis - physiology ; Humans ; inflammatory bowel disease ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Thrombosis - complications ; ulcerative colitis</subject><ispartof>Thrombosis research, 1996-04, Vol.82 (2), p.137-146</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-845bb621bfa03fd681224ed2caae73ff87f9886831545f20ae19f1400e70ed8d3</citedby><cites>FETCH-LOGICAL-c452t-845bb621bfa03fd681224ed2caae73ff87f9886831545f20ae19f1400e70ed8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0049-3848(96)00060-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3064924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9163067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiarantini, Elena</creatorcontrib><creatorcontrib>Valanzano, Rosa</creatorcontrib><creatorcontrib>Liotta, Agatina Alessandrello</creatorcontrib><creatorcontrib>Cellai, Anna Paola</creatorcontrib><creatorcontrib>Fedi, Sandra</creatorcontrib><creatorcontrib>Ilari, Isabella</creatorcontrib><creatorcontrib>Prisco, Demenico</creatorcontrib><creatorcontrib>Tonelli, Francesco</creatorcontrib><creatorcontrib>Abbate, Rosanna</creatorcontrib><title>Hemostatic abnormalities in inflammatory bowel disease</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Patients affected by inflammatory bowel disease (IBD) frequently suffer from thromboembolic events. Aims of this study were to investigate hemostatic system and the presence of antiphospholipid antibodies (aPL) in IBD patients. Forty-one patients affected by Crohn's disease (CD) and 19 by ulcerative colitis (UC) were studied, compared to 40 healthy control subjects. platelet count (PLT), PT, aPTT, fibrinogen (Fib), prothrombin fragment F1+2, antithrombin (AT), protein C (PC), protein S (PS), factor XIII (FXIII), plasminogen (PLG), plasminogen activator inhibitor (PAI), spontaneous platelet aggregation in platelet-rich plasma (PRP-SPA) and in whole blood (WB-SPA), and antiphospholipid antibodies (aPL) were evaluated. PLT, Fib, F1+2 and WB-SPA were significantly increased in IBD patients (p at least <0.05) both in active and inactive phases; aPL positivity was more frequent (p<0.05) and FXIII was significantly decreased (p<0.05) in comparison to control subjects. The thrombophilic state of IBD patients is not related to the degree of activity of the disease or to previous thrombotic events; aPL express the immunological alterations connected with IBD and are not the main cause of thrombotic events.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Antiphospholipid - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation - immunology</subject><subject>coagulation</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colitis, Ulcerative - complications</subject><subject>Colitis, Ulcerative - immunology</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - immunology</subject><subject>Crohn's disease</subject><subject>Female</subject><subject>fibrinolysis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hemostasis - physiology</subject><subject>Humans</subject><subject>inflammatory bowel disease</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Thrombosis - complications</subject><subject>ulcerative colitis</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDdZKmaXIRZFFXWPCi55CmE4j0Y026yv57W7bsURgYhveZYXgIuaRwT4GKBwCu0kxyeavEHQAISMURmVNZqJTxgh2T-QE5JWcxfgHQgqp8RmaKigxEMSdihU0Xe9N7m5iy7UJjat97jIlvh3K1aRrTd2GXlN0v1knlI5qI5-TEmTrixdQX5PPl-WO5Stfvr2_Lp3Vqec76VPK8LAWjpTOQuUpIyhjHilljsMick4VTUgqZ0ZznjoFBqhzlAFgAVrLKFuRmf3cTuu8txl43Plqsa9Nit426kDyjMpMDyPegDV2MAZ3eBN-YsNMU9KhLjy706EKrcRh0aTGsXU33t2WD1WFp8jPk11NuojW1C6a1Ph6wgeGK8QF73GM4uPjxGHS0HluLlQ9oe111_v8__gBj94WR</recordid><startdate>19960415</startdate><enddate>19960415</enddate><creator>Chiarantini, Elena</creator><creator>Valanzano, Rosa</creator><creator>Liotta, Agatina Alessandrello</creator><creator>Cellai, Anna Paola</creator><creator>Fedi, Sandra</creator><creator>Ilari, Isabella</creator><creator>Prisco, Demenico</creator><creator>Tonelli, Francesco</creator><creator>Abbate, Rosanna</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960415</creationdate><title>Hemostatic abnormalities in inflammatory bowel disease</title><author>Chiarantini, Elena ; Valanzano, Rosa ; Liotta, Agatina Alessandrello ; Cellai, Anna Paola ; Fedi, Sandra ; Ilari, Isabella ; Prisco, Demenico ; Tonelli, Francesco ; Abbate, Rosanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-845bb621bfa03fd681224ed2caae73ff87f9886831545f20ae19f1400e70ed8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Antiphospholipid - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation - immunology</topic><topic>coagulation</topic><topic>Colitis, Ulcerative - blood</topic><topic>Colitis, Ulcerative - complications</topic><topic>Colitis, Ulcerative - immunology</topic><topic>Crohn Disease - blood</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - immunology</topic><topic>Crohn's disease</topic><topic>Female</topic><topic>fibrinolysis</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hemostasis - physiology</topic><topic>Humans</topic><topic>inflammatory bowel disease</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Thrombosis - complications</topic><topic>ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiarantini, Elena</creatorcontrib><creatorcontrib>Valanzano, Rosa</creatorcontrib><creatorcontrib>Liotta, Agatina Alessandrello</creatorcontrib><creatorcontrib>Cellai, Anna Paola</creatorcontrib><creatorcontrib>Fedi, Sandra</creatorcontrib><creatorcontrib>Ilari, Isabella</creatorcontrib><creatorcontrib>Prisco, Demenico</creatorcontrib><creatorcontrib>Tonelli, Francesco</creatorcontrib><creatorcontrib>Abbate, Rosanna</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiarantini, Elena</au><au>Valanzano, Rosa</au><au>Liotta, Agatina Alessandrello</au><au>Cellai, Anna Paola</au><au>Fedi, Sandra</au><au>Ilari, Isabella</au><au>Prisco, Demenico</au><au>Tonelli, Francesco</au><au>Abbate, Rosanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemostatic abnormalities in inflammatory bowel disease</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1996-04-15</date><risdate>1996</risdate><volume>82</volume><issue>2</issue><spage>137</spage><epage>146</epage><pages>137-146</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Patients affected by inflammatory bowel disease (IBD) frequently suffer from thromboembolic events. Aims of this study were to investigate hemostatic system and the presence of antiphospholipid antibodies (aPL) in IBD patients. Forty-one patients affected by Crohn's disease (CD) and 19 by ulcerative colitis (UC) were studied, compared to 40 healthy control subjects. platelet count (PLT), PT, aPTT, fibrinogen (Fib), prothrombin fragment F1+2, antithrombin (AT), protein C (PC), protein S (PS), factor XIII (FXIII), plasminogen (PLG), plasminogen activator inhibitor (PAI), spontaneous platelet aggregation in platelet-rich plasma (PRP-SPA) and in whole blood (WB-SPA), and antiphospholipid antibodies (aPL) were evaluated. PLT, Fib, F1+2 and WB-SPA were significantly increased in IBD patients (p at least <0.05) both in active and inactive phases; aPL positivity was more frequent (p<0.05) and FXIII was significantly decreased (p<0.05) in comparison to control subjects. The thrombophilic state of IBD patients is not related to the degree of activity of the disease or to previous thrombotic events; aPL express the immunological alterations connected with IBD and are not the main cause of thrombotic events.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>9163067</pmid><doi>10.1016/0049-3848(96)00060-6</doi><tpages>10</tpages></addata></record> |
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| ispartof | Thrombosis research, 1996-04, Vol.82 (2), p.137-146 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antibodies, Antiphospholipid - blood Biological and medical sciences Blood Coagulation - immunology coagulation Colitis, Ulcerative - blood Colitis, Ulcerative - complications Colitis, Ulcerative - immunology Crohn Disease - blood Crohn Disease - complications Crohn Disease - immunology Crohn's disease Female fibrinolysis Gastroenterology. Liver. Pancreas. Abdomen Hemostasis - physiology Humans inflammatory bowel disease Male Medical sciences Middle Aged Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thrombosis - complications ulcerative colitis |
| title | Hemostatic abnormalities in inflammatory bowel disease |
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