Functional renal maturation in rat neonates after prenatal exposure to furosemide
We investigated the pattern of functional renal maturation and electrolyte handling on postnatal day 1, (PD1), day 5 (PD5), and day 12 (PD12) in rat neonates, after mothers were given furosemide during pregnancy. The drug was administered (75 mg/kg per day i.p.) on day 7-11 (organogenesis) and 14-18...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 1996-08, Vol.10 (4), p.458-460 |
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| creator | MALLIE, J. P BOUDZOUMOU, P |
| description | We investigated the pattern of functional renal maturation and electrolyte handling on postnatal day 1, (PD1), day 5 (PD5), and day 12 (PD12) in rat neonates, after mothers were given furosemide during pregnancy. The drug was administered (75 mg/kg per day i.p.) on day 7-11 (organogenesis) and 14-18 (nephrogenesis) of gestation. On PD1 and PD5, there was a disturbance of the urinary concentrating ability with a hyperdiuresis and an over-stimulated ionic exchange, mainly the distal sodium reabsorption. From PD1 to PD12, a progressive functional recovery in electrolyte handling appeared. However, on PD12, when nephrogenesis was achieved, the renal concentrating defect remained. We discuss the possibility of a drug-induced delay in the development of the loop of Henle, leading to functional and morphological adaptations of already developed parts of the nephron. |
| doi_str_mv | 10.1007/s004670050139 |
| format | Article |
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We discuss the possibility of a drug-induced delay in the development of the loop of Henle, leading to functional and morphological adaptations of already developed parts of the nephron.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s004670050139</identifier><identifier>PMID: 8865243</identifier><identifier>CODEN: PENED3</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Animals, Newborn - physiology ; Biological and medical sciences ; Diuretics - pharmacology ; Electrolytes - urine ; Female ; Furosemide - pharmacology ; Kidney - drug effects ; Kidney - growth & development ; Kidney - metabolism ; Male ; Medical sciences ; Pharmacology. 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| ispartof | Pediatric nephrology (Berlin, West), 1996-08, Vol.10 (4), p.458-460 |
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| subjects | Animals Animals, Newborn - physiology Biological and medical sciences Diuretics - pharmacology Electrolytes - urine Female Furosemide - pharmacology Kidney - drug effects Kidney - growth & development Kidney - metabolism Male Medical sciences Pharmacology. Drug treatments Pregnancy Prenatal exposure Prenatal Exposure Delayed Effects Rats Rats, Wistar Urinary system Weight Gain - drug effects |
| title | Functional renal maturation in rat neonates after prenatal exposure to furosemide |
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