Audiogenic and audiogenic-like seizures: Locus of induction and seizure severity determine postictal prolactin patterns
Audiogenic seizures (AS) are a model of generalized tonicclonic seizures, evoked by high-intensity (110 dB) acoustic stimulation evaluated by means of behavioral severity indexes (SI). Postictal prolactin (PRL) is a marker of generalized seizures, both in animals and humans. Thus, in the present wor...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1996-03, Vol.53 (3), p.503-510 |
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| creator | Garcia-Cairasco, N. Doretto, M.C. Ramalho, M.J. Antunes-Rodrigues, J. Nonaka, K.O. |
| description | Audiogenic seizures (AS) are a model of generalized tonicclonic seizures, evoked by high-intensity (110 dB) acoustic stimulation evaluated by means of behavioral severity indexes (SI). Postictal prolactin (PRL) is a marker of generalized seizures, both in animals and humans. Thus, in the present work we assayed postictal PRL in a) male Wistar AS susceptible (S,
n = 5) and AS resistant (R,
n = 13) rats made susceptible by specific midbrain lesions, b) In rats electrically stimulated in the central nucleus (CN) of the inferior colliculus (IC) (
n = 20), or the cortical IC (CxIC,
n = 18). In c) S rats pretreated with either bromocriptine (BRO; 4 mg/kg; SC), a PRL release inhibitor, or vehicle (V), 30 min before the electrical stimulation. Basal PRL was 2–10 ng/ml at time 0. In the S group, only animals with generalized seizures presented a postictal PRL elevation between 5 and 15 min (60–90 ng/ml;
p < 0.05). R rats displayed a discrete PRL response lower than that of S animals. CxIC stimulation produced more severe seizures and greater postictal PRL enhancement than CNIC stimulation, always raising at 5–15 min (
p < 0.01). BRO blocked the PRL increase even in the presence of higher seizure scores (
p < 0.02). The positive correlation between seizure intensity (SI values), site of initiation (central or cortical IC nuclei), and postictal PRL patterns makes this a reliable model for studying the neurochemistry of the postictal phase and the interaction between hormones and epilepsy. |
| doi_str_mv | 10.1016/0091-3057(95)02040-3 |
| format | Article |
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n = 5) and AS resistant (R,
n = 13) rats made susceptible by specific midbrain lesions, b) In rats electrically stimulated in the central nucleus (CN) of the inferior colliculus (IC) (
n = 20), or the cortical IC (CxIC,
n = 18). In c) S rats pretreated with either bromocriptine (BRO; 4 mg/kg; SC), a PRL release inhibitor, or vehicle (V), 30 min before the electrical stimulation. Basal PRL was 2–10 ng/ml at time 0. In the S group, only animals with generalized seizures presented a postictal PRL elevation between 5 and 15 min (60–90 ng/ml;
p < 0.05). R rats displayed a discrete PRL response lower than that of S animals. CxIC stimulation produced more severe seizures and greater postictal PRL enhancement than CNIC stimulation, always raising at 5–15 min (
p < 0.01). BRO blocked the PRL increase even in the presence of higher seizure scores (
p < 0.02). The positive correlation between seizure intensity (SI values), site of initiation (central or cortical IC nuclei), and postictal PRL patterns makes this a reliable model for studying the neurochemistry of the postictal phase and the interaction between hormones and epilepsy.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(95)02040-3</identifier><identifier>PMID: 8866947</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acoustic Stimulation ; Animals ; Audiogenic seizures ; Audiogenic-like seizures ; Biological and medical sciences ; Disease Models, Animal ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Inferior colliculus lesions ; Inferior colliculus nuclei ; Male ; Medical sciences ; Models, Neurological ; Nervous system (semeiology, syndromes) ; Neurology ; Postictal prolactin ; Prolactin - blood ; Prolactin - metabolism ; Rats ; Rats, Wistar ; Seizures - metabolism ; Substantia nigra lesions ; Time Factors</subject><ispartof>Pharmacology, biochemistry and behavior, 1996-03, Vol.53 (3), p.503-510</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-b47b4c3a47814385d8d920becb9054df76ada3c0be5616e5ad9212d804689da93</citedby><cites>FETCH-LOGICAL-c386t-b47b4c3a47814385d8d920becb9054df76ada3c0be5616e5ad9212d804689da93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(95)02040-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3046169$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8866947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Cairasco, N.</creatorcontrib><creatorcontrib>Doretto, M.C.</creatorcontrib><creatorcontrib>Ramalho, M.J.</creatorcontrib><creatorcontrib>Antunes-Rodrigues, J.</creatorcontrib><creatorcontrib>Nonaka, K.O.</creatorcontrib><title>Audiogenic and audiogenic-like seizures: Locus of induction and seizure severity determine postictal prolactin patterns</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Audiogenic seizures (AS) are a model of generalized tonicclonic seizures, evoked by high-intensity (110 dB) acoustic stimulation evaluated by means of behavioral severity indexes (SI). Postictal prolactin (PRL) is a marker of generalized seizures, both in animals and humans. Thus, in the present work we assayed postictal PRL in a) male Wistar AS susceptible (S,
n = 5) and AS resistant (R,
n = 13) rats made susceptible by specific midbrain lesions, b) In rats electrically stimulated in the central nucleus (CN) of the inferior colliculus (IC) (
n = 20), or the cortical IC (CxIC,
n = 18). In c) S rats pretreated with either bromocriptine (BRO; 4 mg/kg; SC), a PRL release inhibitor, or vehicle (V), 30 min before the electrical stimulation. Basal PRL was 2–10 ng/ml at time 0. In the S group, only animals with generalized seizures presented a postictal PRL elevation between 5 and 15 min (60–90 ng/ml;
p < 0.05). R rats displayed a discrete PRL response lower than that of S animals. CxIC stimulation produced more severe seizures and greater postictal PRL enhancement than CNIC stimulation, always raising at 5–15 min (
p < 0.01). BRO blocked the PRL increase even in the presence of higher seizure scores (
p < 0.02). The positive correlation between seizure intensity (SI values), site of initiation (central or cortical IC nuclei), and postictal PRL patterns makes this a reliable model for studying the neurochemistry of the postictal phase and the interaction between hormones and epilepsy.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Audiogenic seizures</subject><subject>Audiogenic-like seizures</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Inferior colliculus lesions</subject><subject>Inferior colliculus nuclei</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Neurological</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Postictal prolactin</subject><subject>Prolactin - blood</subject><subject>Prolactin - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seizures - metabolism</subject><subject>Substantia nigra lesions</subject><subject>Time Factors</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrHDEQhEVIsDdO_kEMOgSTHCaRVho9fDAYkxcs-OKchUbqCYpnpbWkcXB-fbTeYY85Nd1V1RQfQu8o-UQJFZ8J0bRjpJcfdP-RrAknHXuBVlRJ1vVUypdodbScotel_CaE8LWQJ-hEKSE0lyv053r2If2CGBy20WN7XLsp3AMuEP7OGcol3iQ3F5xGHKKfXQ0pPgcWQ5uPkEN9wh4q5G2IgHep1OCqnfAup8m2TMQ7W5scyxv0arRTgbfLPEM_v365u_nebW6__bi53nSOKVG7gcuBO2a5VJQz1Xvl9ZoM4AZNeu5HKay3zLVLL6iA3jaZrr0iXCjtrWZn6OLwt1V4mKFUsw3FwTTZCGkuRire-GjRjPxgdDmVkmE0uxy2Nj8ZSsyet9nDNHuYRvfmmbdhLXa-_J-HLfhjaAHc9PeLbouz05htdKEcbawVpWJf8-pgg8biMUA2xQWIDnzI4KrxKfy_xz_I6J5U</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Garcia-Cairasco, N.</creator><creator>Doretto, M.C.</creator><creator>Ramalho, M.J.</creator><creator>Antunes-Rodrigues, J.</creator><creator>Nonaka, K.O.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>Audiogenic and audiogenic-like seizures: Locus of induction and seizure severity determine postictal prolactin patterns</title><author>Garcia-Cairasco, N. ; Doretto, M.C. ; Ramalho, M.J. ; Antunes-Rodrigues, J. ; Nonaka, K.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-b47b4c3a47814385d8d920becb9054df76ada3c0be5616e5ad9212d804689da93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Audiogenic seizures</topic><topic>Audiogenic-like seizures</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Inferior colliculus lesions</topic><topic>Inferior colliculus nuclei</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Neurological</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Postictal prolactin</topic><topic>Prolactin - blood</topic><topic>Prolactin - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seizures - metabolism</topic><topic>Substantia nigra lesions</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Cairasco, N.</creatorcontrib><creatorcontrib>Doretto, M.C.</creatorcontrib><creatorcontrib>Ramalho, M.J.</creatorcontrib><creatorcontrib>Antunes-Rodrigues, J.</creatorcontrib><creatorcontrib>Nonaka, K.O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Cairasco, N.</au><au>Doretto, M.C.</au><au>Ramalho, M.J.</au><au>Antunes-Rodrigues, J.</au><au>Nonaka, K.O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Audiogenic and audiogenic-like seizures: Locus of induction and seizure severity determine postictal prolactin patterns</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>53</volume><issue>3</issue><spage>503</spage><epage>510</epage><pages>503-510</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Audiogenic seizures (AS) are a model of generalized tonicclonic seizures, evoked by high-intensity (110 dB) acoustic stimulation evaluated by means of behavioral severity indexes (SI). Postictal prolactin (PRL) is a marker of generalized seizures, both in animals and humans. Thus, in the present work we assayed postictal PRL in a) male Wistar AS susceptible (S,
n = 5) and AS resistant (R,
n = 13) rats made susceptible by specific midbrain lesions, b) In rats electrically stimulated in the central nucleus (CN) of the inferior colliculus (IC) (
n = 20), or the cortical IC (CxIC,
n = 18). In c) S rats pretreated with either bromocriptine (BRO; 4 mg/kg; SC), a PRL release inhibitor, or vehicle (V), 30 min before the electrical stimulation. Basal PRL was 2–10 ng/ml at time 0. In the S group, only animals with generalized seizures presented a postictal PRL elevation between 5 and 15 min (60–90 ng/ml;
p < 0.05). R rats displayed a discrete PRL response lower than that of S animals. CxIC stimulation produced more severe seizures and greater postictal PRL enhancement than CNIC stimulation, always raising at 5–15 min (
p < 0.01). BRO blocked the PRL increase even in the presence of higher seizure scores (
p < 0.02). The positive correlation between seizure intensity (SI values), site of initiation (central or cortical IC nuclei), and postictal PRL patterns makes this a reliable model for studying the neurochemistry of the postictal phase and the interaction between hormones and epilepsy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8866947</pmid><doi>10.1016/0091-3057(95)02040-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1996-03, Vol.53 (3), p.503-510 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78430596 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acoustic Stimulation Animals Audiogenic seizures Audiogenic-like seizures Biological and medical sciences Disease Models, Animal Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Inferior colliculus lesions Inferior colliculus nuclei Male Medical sciences Models, Neurological Nervous system (semeiology, syndromes) Neurology Postictal prolactin Prolactin - blood Prolactin - metabolism Rats Rats, Wistar Seizures - metabolism Substantia nigra lesions Time Factors |
| title | Audiogenic and audiogenic-like seizures: Locus of induction and seizure severity determine postictal prolactin patterns |
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