Hepatic Photopenia in Gallium Imaging
Although Ga-67 has been used extensively in Imaging many different conditions, much is yet unknown about the mechanisms by which gallium concentrates preferentially in tissues such as the liver. This paper reports three patients with markedly diminished hepatic uptake of gallium. The cases are exami...
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| Veröffentlicht in: | Clin. Nucl. Med.; (United States) 1988-07, Vol.13 (7), p.502-505 |
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| container_title | Clin. Nucl. Med.; (United States) |
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| creator | GLASER, ANNE M CHEN, DAVID C. P SIEGEL, MICHAEL E |
| description | Although Ga-67 has been used extensively in Imaging many different conditions, much is yet unknown about the mechanisms by which gallium concentrates preferentially in tissues such as the liver. This paper reports three patients with markedly diminished hepatic uptake of gallium. The cases are examined in light of published data demonstrating such factors as transferrin levels, radiation, and chemotherapeutic agents as altering the hepatic uptake of gallium. Of the many factors believed to influence the biodistribution of gallium, none can definitively account for the lack of hepatic uptake in these patients. |
| doi_str_mv | 10.1097/00003072-198807000-00006 |
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Of the many factors believed to influence the biodistribution of gallium, none can definitively account for the lack of hepatic uptake in these patients.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/00003072-198807000-00006</identifier><identifier>PMID: 3048831</identifier><identifier>CODEN: CNMEDK</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man ; Acquired Immunodeficiency Syndrome - diagnostic imaging ; Adult ; AIDS/HIV ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BODY ; DAYS LIVING RADIOISOTOPES ; DIGESTIVE SYSTEM ; DISTRIBUTION ; ELECTRON CAPTURE RADIOISOTOPES ; Female ; GALLIUM 67 ; GALLIUM ISOTOPES ; Gallium Radioisotopes - pharmacokinetics ; GLANDS ; Hematologic and hematopoietic diseases ; Humans ; IMAGE PROCESSING ; INTERMEDIATE MASS NUCLEI ; ISOTOPES ; Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging ; Leukemia, T-Cell - diagnostic imaging ; Leukemias. 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P</creatorcontrib><creatorcontrib>SIEGEL, MICHAEL E</creatorcontrib><creatorcontrib>Univ. of Southern California, Los Angeles (USA)</creatorcontrib><title>Hepatic Photopenia in Gallium Imaging</title><title>Clin. Nucl. Med.; (United States)</title><addtitle>Clin Nucl Med</addtitle><description>Although Ga-67 has been used extensively in Imaging many different conditions, much is yet unknown about the mechanisms by which gallium concentrates preferentially in tissues such as the liver. This paper reports three patients with markedly diminished hepatic uptake of gallium. The cases are examined in light of published data demonstrating such factors as transferrin levels, radiation, and chemotherapeutic agents as altering the hepatic uptake of gallium. Of the many factors believed to influence the biodistribution of gallium, none can definitively account for the lack of hepatic uptake in these patients.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>560161 - Radionuclide Effects, Kinetics, & Toxicology- Man</subject><subject>Acquired Immunodeficiency Syndrome - diagnostic imaging</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIGESTIVE SYSTEM</subject><subject>DISTRIBUTION</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>Female</subject><subject>GALLIUM 67</subject><subject>GALLIUM ISOTOPES</subject><subject>Gallium Radioisotopes - pharmacokinetics</subject><subject>GLANDS</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>IMAGE PROCESSING</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>ISOTOPES</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging</subject><subject>Leukemia, T-Cell - diagnostic imaging</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>LIVER</subject><subject>Liver - diagnostic imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>PROCESSING</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>TISSUE DISTRIBUTION</subject><subject>UPTAKE</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV9LwzAUxYMoc04_glBEfasmzf9HGToHA33Q55ClyRpN29m0DL-9mZt7My-XnPs7N-FcADIE7xCU_B6mgyEvciSFgDzd8q3EjsAYUcxyWBTyGIwhZjiXnBWn4CzGDwgRQ4yMwAhDIgRGY3DzbNe69yZ7rdq-XdvG68w32UyH4Ic6m9d65ZvVOThxOkR7sa8T8P70-DZ9zhcvs_n0YZEbLCjLRSkoKZmgCBuql4RZt4RECkmZdrhwS00kcdwxSgpBbJINldwZx1hJLRZ4Aq52c9vYexWN762pTNs01vQquWDBSYJud9C6a78GG3tV-2hsCLqx7RAVF6SQUOAEih1oujbGzjq17nytu2-FoNrGqP5iVIcYfyWWrJf7N4ZlbcuDcZ9b6l_v-zoaHVynG-PjAeMpcky3XyU7bNOG3nbxMwwb26nK6tBX6r8l4h8Vx4Zw</recordid><startdate>198807</startdate><enddate>198807</enddate><creator>GLASER, ANNE M</creator><creator>CHEN, DAVID C. P</creator><creator>SIEGEL, MICHAEL E</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198807</creationdate><title>Hepatic Photopenia in Gallium Imaging</title><author>GLASER, ANNE M ; CHEN, DAVID C. P ; SIEGEL, MICHAEL E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3856-8d854d68513c5ab46efb0498956af32fba494f7f654284e956c597fcf66d5e383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>560161 - Radionuclide Effects, Kinetics, & Toxicology- Man</topic><topic>Acquired Immunodeficiency Syndrome - diagnostic imaging</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIGESTIVE SYSTEM</topic><topic>DISTRIBUTION</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>Female</topic><topic>GALLIUM 67</topic><topic>GALLIUM ISOTOPES</topic><topic>Gallium Radioisotopes - pharmacokinetics</topic><topic>GLANDS</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>IMAGE PROCESSING</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>ISOTOPES</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging</topic><topic>Leukemia, T-Cell - diagnostic imaging</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>LIVER</topic><topic>Liver - diagnostic imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>PROCESSING</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>TISSUE DISTRIBUTION</topic><topic>UPTAKE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GLASER, ANNE M</creatorcontrib><creatorcontrib>CHEN, DAVID C. P</creatorcontrib><creatorcontrib>SIEGEL, MICHAEL E</creatorcontrib><creatorcontrib>Univ. of Southern California, Los Angeles (USA)</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Clin. Nucl. Med.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GLASER, ANNE M</au><au>CHEN, DAVID C. P</au><au>SIEGEL, MICHAEL E</au><aucorp>Univ. of Southern California, Los Angeles (USA)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatic Photopenia in Gallium Imaging</atitle><jtitle>Clin. Nucl. Med.; (United States)</jtitle><addtitle>Clin Nucl Med</addtitle><date>1988-07</date><risdate>1988</risdate><volume>13</volume><issue>7</issue><spage>502</spage><epage>505</epage><pages>502-505</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><coden>CNMEDK</coden><abstract>Although Ga-67 has been used extensively in Imaging many different conditions, much is yet unknown about the mechanisms by which gallium concentrates preferentially in tissues such as the liver. This paper reports three patients with markedly diminished hepatic uptake of gallium. The cases are examined in light of published data demonstrating such factors as transferrin levels, radiation, and chemotherapeutic agents as altering the hepatic uptake of gallium. Of the many factors believed to influence the biodistribution of gallium, none can definitively account for the lack of hepatic uptake in these patients.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>3048831</pmid><doi>10.1097/00003072-198807000-00006</doi><tpages>4</tpages></addata></record> |
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| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man Acquired Immunodeficiency Syndrome - diagnostic imaging Adult AIDS/HIV BETA DECAY RADIOISOTOPES Biological and medical sciences BODY DAYS LIVING RADIOISOTOPES DIGESTIVE SYSTEM DISTRIBUTION ELECTRON CAPTURE RADIOISOTOPES Female GALLIUM 67 GALLIUM ISOTOPES Gallium Radioisotopes - pharmacokinetics GLANDS Hematologic and hematopoietic diseases Humans IMAGE PROCESSING INTERMEDIATE MASS NUCLEI ISOTOPES Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging Leukemia, T-Cell - diagnostic imaging Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis LIVER Liver - diagnostic imaging Male Medical sciences NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS PROCESSING RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging TISSUE DISTRIBUTION UPTAKE |
| title | Hepatic Photopenia in Gallium Imaging |
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