Aggressive variants of chromophobe renal cell carcinoma
BACKGROUND Chromophobe renal cell carcinoma (RCC) is a distinctive subtype of RCC with a more favorable prognosis than clear cell RCC. We describe the pathologic features of 23 solitary cases and 2 cases with coexistent papillary RCCs, 7 of which developed metastases. METHODS Cases were retrieved fr...
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| Veröffentlicht in: | Cancer 1996-10, Vol.78 (8), p.1756-1761 |
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| creator | Renshaw, Andrew A. Henske, Elizabeth P. Loughlin, Kevin R. Shapiro, Charles Weinberg, David S. |
| description | BACKGROUND
Chromophobe renal cell carcinoma (RCC) is a distinctive subtype of RCC with a more favorable prognosis than clear cell RCC. We describe the pathologic features of 23 solitary cases and 2 cases with coexistent papillary RCCs, 7 of which developed metastases.
METHODS
Cases were retrieved from the pathology files of our institutions. Clinical follow‐up was obtained from the medical records. DNA analysis was performed on Feulgen‐stained slides using image analysis.
RESULTS
Twenty‐five cases were identified. All cases had characteristic pathologic features, including diffuse cytoplasmic reactivity for Hale's colloidal iron. DNA ploidy analysis of ten cases revealed a diploid pattern in five, a hyperdiploid pattern in four, and a hypodiploid pattern in one. Follow‐up was available for 20 cases, and metastases developed in 7 (from 4 to 120 months after surgery). In 5 of these cases, the tumors were solitary and more than 8 cm in greatest dimension and metastases developed in the liver. In both cases with papillary RCCs in the same kidney, metastases developed in the lung, although which tumor metastasized is unknown.
CONCLUSIONS
Despite the overall favorable prognosis for chromophobe RCC, large tumors and those with coexistent papillary RCCs may produce in metastases. Cancer 1996;78:1756‐61. |
| doi_str_mv | 10.1002/(SICI)1097-0142(19961015)78:8<1756::AID-CNCR16>3.0.CO;2-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78428510</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78428510</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4676-48545305799a767dd74d5550b7451e993f228e502d05a47d684e893c3af509593</originalsourceid><addsrcrecordid>eNqFkF1rFDEUhoModVv9CcJciLQXs558nEmyirCMXwvFBT9gxYtDdibTjszHmnRb-u-dYce9UfAmIec8eXl5GFtymHMA8fL8yypfXXCwOgWuxDm3NuPA8UKbhXnNNWaLxXL1Ns0_5Z959kbOYZ6vX4l084DNjr8eshkAmBSV3DxmpzH-HJ5aoDxhJ8ag5cbOmF5eXQUfY33rk1sXatfdxKSvkuI69G2_u-63Pgm-c01S-GY4XCjqrm_dE_aock30T6f7jH17_-5r_jG9XH9Y5cvLtFCZzlJlUKEE1NY6nemy1KpERNhqhdxbKyshjEcQJaBTusyM8sbKQroKwaKVZ-zFIXcX-l97H2-oreNYxXW-30fSRgmDHAbw-wEsQh9j8BXtQt26cE8caJRKNEqlUQ-NeuiP1CGDDI1SiQapdJBKkoDyNQnaDNnPphL7bevLY_Jkcdg_n_YuFq6pguuKOh4xKaQWygzYjwN2Vzf-_q9-_6_3z3bTRP4Gf02eHQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78428510</pqid></control><display><type>article</type><title>Aggressive variants of chromophobe renal cell carcinoma</title><source>MEDLINE</source><source>Wiley Journals</source><source>Wiley Online Library Free Content</source><source>Alma/SFX Local Collection</source><creator>Renshaw, Andrew A. ; Henske, Elizabeth P. ; Loughlin, Kevin R. ; Shapiro, Charles ; Weinberg, David S.</creator><creatorcontrib>Renshaw, Andrew A. ; Henske, Elizabeth P. ; Loughlin, Kevin R. ; Shapiro, Charles ; Weinberg, David S.</creatorcontrib><description>BACKGROUND
Chromophobe renal cell carcinoma (RCC) is a distinctive subtype of RCC with a more favorable prognosis than clear cell RCC. We describe the pathologic features of 23 solitary cases and 2 cases with coexistent papillary RCCs, 7 of which developed metastases.
METHODS
Cases were retrieved from the pathology files of our institutions. Clinical follow‐up was obtained from the medical records. DNA analysis was performed on Feulgen‐stained slides using image analysis.
RESULTS
Twenty‐five cases were identified. All cases had characteristic pathologic features, including diffuse cytoplasmic reactivity for Hale's colloidal iron. DNA ploidy analysis of ten cases revealed a diploid pattern in five, a hyperdiploid pattern in four, and a hypodiploid pattern in one. Follow‐up was available for 20 cases, and metastases developed in 7 (from 4 to 120 months after surgery). In 5 of these cases, the tumors were solitary and more than 8 cm in greatest dimension and metastases developed in the liver. In both cases with papillary RCCs in the same kidney, metastases developed in the lung, although which tumor metastasized is unknown.
CONCLUSIONS
Despite the overall favorable prognosis for chromophobe RCC, large tumors and those with coexistent papillary RCCs may produce in metastases. Cancer 1996;78:1756‐61.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/(SICI)1097-0142(19961015)78:8<1756::AID-CNCR16>3.0.CO;2-X</identifier><identifier>PMID: 8859189</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - pathology ; Adult ; Aged ; Biological and medical sciences ; Carcinoma, Renal Cell - pathology ; chromophobe ; Female ; Flow Cytometry ; Humans ; Kidney Neoplasms - pathology ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Neoplasm Metastasis ; Nephrology. Urinary tract diseases ; pathology ; Ploidies ; ploidy ; Prognosis ; renal cell carcinoma ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>Cancer, 1996-10, Vol.78 (8), p.1756-1761</ispartof><rights>Copyright © 1996 American Cancer Society</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4676-48545305799a767dd74d5550b7451e993f228e502d05a47d684e893c3af509593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0142%2819961015%2978%3A8%3C1756%3A%3AAID-CNCR16%3E3.0.CO%3B2-X$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0142%2819961015%2978%3A8%3C1756%3A%3AAID-CNCR16%3E3.0.CO%3B2-X$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3237248$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8859189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Renshaw, Andrew A.</creatorcontrib><creatorcontrib>Henske, Elizabeth P.</creatorcontrib><creatorcontrib>Loughlin, Kevin R.</creatorcontrib><creatorcontrib>Shapiro, Charles</creatorcontrib><creatorcontrib>Weinberg, David S.</creatorcontrib><title>Aggressive variants of chromophobe renal cell carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Chromophobe renal cell carcinoma (RCC) is a distinctive subtype of RCC with a more favorable prognosis than clear cell RCC. We describe the pathologic features of 23 solitary cases and 2 cases with coexistent papillary RCCs, 7 of which developed metastases.
METHODS
Cases were retrieved from the pathology files of our institutions. Clinical follow‐up was obtained from the medical records. DNA analysis was performed on Feulgen‐stained slides using image analysis.
RESULTS
Twenty‐five cases were identified. All cases had characteristic pathologic features, including diffuse cytoplasmic reactivity for Hale's colloidal iron. DNA ploidy analysis of ten cases revealed a diploid pattern in five, a hyperdiploid pattern in four, and a hypodiploid pattern in one. Follow‐up was available for 20 cases, and metastases developed in 7 (from 4 to 120 months after surgery). In 5 of these cases, the tumors were solitary and more than 8 cm in greatest dimension and metastases developed in the liver. In both cases with papillary RCCs in the same kidney, metastases developed in the lung, although which tumor metastasized is unknown.
CONCLUSIONS
Despite the overall favorable prognosis for chromophobe RCC, large tumors and those with coexistent papillary RCCs may produce in metastases. Cancer 1996;78:1756‐61.</description><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>chromophobe</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>pathology</subject><subject>Ploidies</subject><subject>ploidy</subject><subject>Prognosis</subject><subject>renal cell carcinoma</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rFDEUhoModVv9CcJciLQXs558nEmyirCMXwvFBT9gxYtDdibTjszHmnRb-u-dYce9UfAmIec8eXl5GFtymHMA8fL8yypfXXCwOgWuxDm3NuPA8UKbhXnNNWaLxXL1Ns0_5Z959kbOYZ6vX4l084DNjr8eshkAmBSV3DxmpzH-HJ5aoDxhJ8ag5cbOmF5eXQUfY33rk1sXatfdxKSvkuI69G2_u-63Pgm-c01S-GY4XCjqrm_dE_aock30T6f7jH17_-5r_jG9XH9Y5cvLtFCZzlJlUKEE1NY6nemy1KpERNhqhdxbKyshjEcQJaBTusyM8sbKQroKwaKVZ-zFIXcX-l97H2-oreNYxXW-30fSRgmDHAbw-wEsQh9j8BXtQt26cE8caJRKNEqlUQ-NeuiP1CGDDI1SiQapdJBKkoDyNQnaDNnPphL7bevLY_Jkcdg_n_YuFq6pguuKOh4xKaQWygzYjwN2Vzf-_q9-_6_3z3bTRP4Gf02eHQ</recordid><startdate>19961015</startdate><enddate>19961015</enddate><creator>Renshaw, Andrew A.</creator><creator>Henske, Elizabeth P.</creator><creator>Loughlin, Kevin R.</creator><creator>Shapiro, Charles</creator><creator>Weinberg, David S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961015</creationdate><title>Aggressive variants of chromophobe renal cell carcinoma</title><author>Renshaw, Andrew A. ; Henske, Elizabeth P. ; Loughlin, Kevin R. ; Shapiro, Charles ; Weinberg, David S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4676-48545305799a767dd74d5550b7451e993f228e502d05a47d684e893c3af509593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>chromophobe</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>pathology</topic><topic>Ploidies</topic><topic>ploidy</topic><topic>Prognosis</topic><topic>renal cell carcinoma</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Renshaw, Andrew A.</creatorcontrib><creatorcontrib>Henske, Elizabeth P.</creatorcontrib><creatorcontrib>Loughlin, Kevin R.</creatorcontrib><creatorcontrib>Shapiro, Charles</creatorcontrib><creatorcontrib>Weinberg, David S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Renshaw, Andrew A.</au><au>Henske, Elizabeth P.</au><au>Loughlin, Kevin R.</au><au>Shapiro, Charles</au><au>Weinberg, David S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aggressive variants of chromophobe renal cell carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1996-10-15</date><risdate>1996</risdate><volume>78</volume><issue>8</issue><spage>1756</spage><epage>1761</epage><pages>1756-1761</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Chromophobe renal cell carcinoma (RCC) is a distinctive subtype of RCC with a more favorable prognosis than clear cell RCC. We describe the pathologic features of 23 solitary cases and 2 cases with coexistent papillary RCCs, 7 of which developed metastases.
METHODS
Cases were retrieved from the pathology files of our institutions. Clinical follow‐up was obtained from the medical records. DNA analysis was performed on Feulgen‐stained slides using image analysis.
RESULTS
Twenty‐five cases were identified. All cases had characteristic pathologic features, including diffuse cytoplasmic reactivity for Hale's colloidal iron. DNA ploidy analysis of ten cases revealed a diploid pattern in five, a hyperdiploid pattern in four, and a hypodiploid pattern in one. Follow‐up was available for 20 cases, and metastases developed in 7 (from 4 to 120 months after surgery). In 5 of these cases, the tumors were solitary and more than 8 cm in greatest dimension and metastases developed in the liver. In both cases with papillary RCCs in the same kidney, metastases developed in the lung, although which tumor metastasized is unknown.
CONCLUSIONS
Despite the overall favorable prognosis for chromophobe RCC, large tumors and those with coexistent papillary RCCs may produce in metastases. Cancer 1996;78:1756‐61.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8859189</pmid><doi>10.1002/(SICI)1097-0142(19961015)78:8<1756::AID-CNCR16>3.0.CO;2-X</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma - pathology Adult Aged Biological and medical sciences Carcinoma, Renal Cell - pathology chromophobe Female Flow Cytometry Humans Kidney Neoplasms - pathology Kidneys Male Medical sciences Middle Aged Neoplasm Metastasis Nephrology. Urinary tract diseases pathology Ploidies ploidy Prognosis renal cell carcinoma Urinary system involvement in other diseases. Miscellaneous |
| title | Aggressive variants of chromophobe renal cell carcinoma |
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