Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat
The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC 50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC 50 values of SP for it...
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| Veröffentlicht in: | Neuropeptides (Edinburgh) 1988-05, Vol.11 (4), p.153-157 |
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| creator | Silva, W.I. Miranda, H.F. Wolstenholme, W.W. Cuevas, N. Ucros, A. |
| description | The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC
50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC
50 values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4–740 nM SP resulted in a decrease in the EC
50 and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC
50 and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor. |
| doi_str_mv | 10.1016/0143-4179(88)90068-6 |
| format | Article |
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50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC
50 values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4–740 nM SP resulted in a decrease in the EC
50 and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC
50 and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor.</description><identifier>ISSN: 0143-4179</identifier><identifier>EISSN: 1532-2785</identifier><identifier>DOI: 10.1016/0143-4179(88)90068-6</identifier><identifier>PMID: 2458536</identifier><identifier>CODEN: NRPPDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Atropine - pharmacology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Male ; Muscle, Smooth - drug effects ; Muscle, Smooth - innervation ; N-Methylscopolamine ; Neostigmine - pharmacology ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Pirenzepine - pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, Muscarinic - drug effects ; Receptors, Neurokinin-1 ; Receptors, Neurotransmitter - drug effects ; Scopolamine Derivatives - pharmacology ; Substance P - antagonists & inhibitors ; Substance P - pharmacology ; Vas Deferens - drug effects ; Vas Deferens - innervation ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuropeptides (Edinburgh), 1988-05, Vol.11 (4), p.153-157</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-9fc703b2dee9588835d72500927c16540104ebac3bdcf4c871797d0cbcb171f73</citedby><cites>FETCH-LOGICAL-c417t-9fc703b2dee9588835d72500927c16540104ebac3bdcf4c871797d0cbcb171f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0143417988900686$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7149035$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2458536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, W.I.</creatorcontrib><creatorcontrib>Miranda, H.F.</creatorcontrib><creatorcontrib>Wolstenholme, W.W.</creatorcontrib><creatorcontrib>Cuevas, N.</creatorcontrib><creatorcontrib>Ucros, A.</creatorcontrib><title>Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat</title><title>Neuropeptides (Edinburgh)</title><addtitle>Neuropeptides</addtitle><description>The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC
50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC
50 values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4–740 nM SP resulted in a decrease in the EC
50 and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC
50 and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor.</description><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - innervation</subject><subject>N-Methylscopolamine</subject><subject>Neostigmine - pharmacology</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Pirenzepine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Muscarinic - drug effects</subject><subject>Receptors, Neurokinin-1</subject><subject>Receptors, Neurotransmitter - drug effects</subject><subject>Scopolamine Derivatives - pharmacology</subject><subject>Substance P - antagonists & inhibitors</subject><subject>Substance P - pharmacology</subject><subject>Vas Deferens - drug effects</subject><subject>Vas Deferens - innervation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0143-4179</issn><issn>1532-2785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PxCAQhonR6PrxDzThYIweqkCh0IuJMX4lRj3omVCYRkxbVmhN_Pey7maPeiJhnncYnkHokJJzSmh1QSgvC05lfarUWU1IpYpqA82oKFnBpBKbaLZGdtBuSh-EEM6U2kbbjAslymqGzBNMMfTBTZ0ZQ_zGxo4-DAmHFqepSaMZLOAXHAY8vgPup2RN9IO3OIKFeY78ooval0nYQQsRhvVdNOM-2mpNl-Bgde6ht9ub1-v74vH57uH66rGwecCxqFsrSdkwB1ALpVQpnGSCkJpJSyvBCSUcGmPLxtmWWyXzr6QjtrENlbSV5R46Wfadx_A5QRp175OFrjMDhClpqTiTjNX_gpTXFRWMZpAvQRtDShFaPY--N_FbU6IXK9ALv3rhVyulf1egqxw7WvWfmh7cOrRynuvHq7rJMrs2ZsU-rTGZ3yelyNjlEoMs7ctD1Ml6yNtwPqsftQv-7zl-ADqKojQ</recordid><startdate>19880501</startdate><enddate>19880501</enddate><creator>Silva, W.I.</creator><creator>Miranda, H.F.</creator><creator>Wolstenholme, W.W.</creator><creator>Cuevas, N.</creator><creator>Ucros, A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880501</creationdate><title>Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat</title><author>Silva, W.I. ; Miranda, H.F. ; Wolstenholme, W.W. ; Cuevas, N. ; Ucros, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-9fc703b2dee9588835d72500927c16540104ebac3bdcf4c871797d0cbcb171f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - innervation</topic><topic>N-Methylscopolamine</topic><topic>Neostigmine - pharmacology</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Pirenzepine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Muscarinic - drug effects</topic><topic>Receptors, Neurokinin-1</topic><topic>Receptors, Neurotransmitter - drug effects</topic><topic>Scopolamine Derivatives - pharmacology</topic><topic>Substance P - antagonists & inhibitors</topic><topic>Substance P - pharmacology</topic><topic>Vas Deferens - drug effects</topic><topic>Vas Deferens - innervation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, W.I.</creatorcontrib><creatorcontrib>Miranda, H.F.</creatorcontrib><creatorcontrib>Wolstenholme, W.W.</creatorcontrib><creatorcontrib>Cuevas, N.</creatorcontrib><creatorcontrib>Ucros, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropeptides (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, W.I.</au><au>Miranda, H.F.</au><au>Wolstenholme, W.W.</au><au>Cuevas, N.</au><au>Ucros, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat</atitle><jtitle>Neuropeptides (Edinburgh)</jtitle><addtitle>Neuropeptides</addtitle><date>1988-05-01</date><risdate>1988</risdate><volume>11</volume><issue>4</issue><spage>153</spage><epage>157</epage><pages>153-157</pages><issn>0143-4179</issn><eissn>1532-2785</eissn><coden>NRPPDD</coden><abstract>The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC
50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC
50 values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4–740 nM SP resulted in a decrease in the EC
50 and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC
50 and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2458536</pmid><doi>10.1016/0143-4179(88)90068-6</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Atropine - pharmacology Biological and medical sciences Fundamental and applied biological sciences. Psychology In Vitro Techniques Male Muscle, Smooth - drug effects Muscle, Smooth - innervation N-Methylscopolamine Neostigmine - pharmacology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Pirenzepine - pharmacology Rats Rats, Inbred Strains Receptors, Muscarinic - drug effects Receptors, Neurokinin-1 Receptors, Neurotransmitter - drug effects Scopolamine Derivatives - pharmacology Substance P - antagonists & inhibitors Substance P - pharmacology Vas Deferens - drug effects Vas Deferens - innervation Vertebrates: nervous system and sense organs |
| title | Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat |
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