NMR studies of carbonic anhydrase-4-fluorobenzenesulfonamide complexes

Binding of 4-fluorobenzenesulfonamide to human carbonic anhydrases I and II has been studied by proton, fluorine, and nitrogen-15 nuclear magnetic resonance spectroscopy. All three types of experiments provide evidence that the stoichiometry of the interaction of this inhibitor with both enzymes is...

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Veröffentlicht in:	Biochemistry (Easton) 1988-06, Vol.27 (12), p.4310-4316
Hauptverfasser:	Dugad, L. B., Gerig, J. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics AMIDES AMMONIUM CHLORIDES AMMONIUM COMPOUNDS AMMONIUM HALIDES ANTI-INFECTIVE AGENTS ANTIMICROBIAL AGENTS BARYONS Biological and medical sciences CARBON-OXYGEN LYASES CARBONIC ANHYDRASE Carbonic Anhydrase Inhibitors - analysis Carbonic Anhydrases - metabolism CHLORIDES CHLORINE COMPOUNDS COMPLEXES DISSOCIATION DRUGS ELEMENTARY PARTICLES ENZYMES FERMIONS FLUORINE 19 FLUORINE ISOTOPES Fluorobenzenes - metabolism Fundamental and applied biological sciences. Psychology HADRONS HALIDES HALOGEN COMPOUNDS HEAVY WATER Humans HYDRO-LYASES HYDROGEN COMPOUNDS Interactions. Associations Intermolecular phenomena Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism ISOTOPES LIGHT NUCLEI LYASES MAGNETIC RESONANCE Magnetic Resonance Spectroscopy METALLOPROTEINS Molecular biophysics NITROGEN 15 NITROGEN ISOTOPES NMR SPECTRA NUCLEAR MAGNETIC RESONANCE NUCLEI NUCLEONS ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS OVERHAUSER EFFECT OXYGEN COMPOUNDS PROTEINS PROTONS RADIOLOGY AND NUCLEAR MEDICINE RELAXATION RESONANCE SPECTRA SPIN-LATTICE RELAXATION STABLE ISOTOPES SULFONAMIDES Sulfonamides - metabolism WATER
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