Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)
The zincins are a superfamily of structurally-related Zn 2+-binding metallopeptidases which play a major role in a wide range of biological processes including pattern formation, growth factor activation and extracellular matrix synthesis and degradation. In this paper we report the identification a...
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| Veröffentlicht in: | Gene 1996-09, Vol.174 (1), p.135-143 |
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| container_title | Gene |
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| creator | Scott, Ian C. Halila, Ritva Jenkins, Joanne M. Mehan, Sharon Apostolou, Sinoula Winqvist, Robert Callen, David F. Prockop, Darwin J. Peltonen, Leena Kadler, Karl E. |
| description | The zincins are a superfamily of structurally-related Zn
2+-binding metallopeptidases which play a major role in a wide range of biological processes including pattern formation, growth factor activation and extracellular matrix synthesis and degradation. In this paper we report the identification and complete primary structure of a novel 33 kDa protein which contains the zinc-binding HEXXH motif found in the zincin superfamily. We have named this novel protein PRSM1 (PRoteaSe, Metallo, number 1). The gene was identified by the immunoscreening of a human placental cDNA library using polyclonal antibodies raised to the 70 kDa human matrix metalloendopeptidase, type III procollagen N-proteinase [Halila, R. and Peltonen, L. (1986) Purification of human procollagen type III N-proteinase from placenta and preparation of antiserum. Biochem. J. 239, 47–52]. The protein is found in placenta and cultured osteosarcoma cells.
PRSM1 could share sequence homology with the type III procollagen N-proteinase. The
prsml gene is represented once in the human genome and is localized on chromosome 16 (q24.3). |
| doi_str_mv | 10.1016/0378-1119(96)00510-0 |
| format | Article |
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2+-binding metallopeptidases which play a major role in a wide range of biological processes including pattern formation, growth factor activation and extracellular matrix synthesis and degradation. In this paper we report the identification and complete primary structure of a novel 33 kDa protein which contains the zinc-binding HEXXH motif found in the zincin superfamily. We have named this novel protein PRSM1 (PRoteaSe, Metallo, number 1). The gene was identified by the immunoscreening of a human placental cDNA library using polyclonal antibodies raised to the 70 kDa human matrix metalloendopeptidase, type III procollagen N-proteinase [Halila, R. and Peltonen, L. (1986) Purification of human procollagen type III N-proteinase from placenta and preparation of antiserum. Biochem. J. 239, 47–52]. The protein is found in placenta and cultured osteosarcoma cells.
PRSM1 could share sequence homology with the type III procollagen N-proteinase. The
prsml gene is represented once in the human genome and is localized on chromosome 16 (q24.3).</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/0378-1119(96)00510-0</identifier><identifier>PMID: 8863740</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Base Sequence ; Chromosome Mapping ; Chromosomes, Human, Pair 16 ; Cloning, Molecular ; Gluzincin ; Humans ; Immunoscreening ; Metalloendopeptidase ; Metalloendopeptidases - genetics ; Metalloproteinase ; Metzincin ; Molecular Sequence Data ; Primary structure ; Recombinant protein ; Sequence Alignment ; Type III collagen ; Type III procollagen N-proteinase ; Zincin</subject><ispartof>Gene, 1996-09, Vol.174 (1), p.135-143</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-fcd04d1f728ffe04aa91a375044911b3de320271d097bc204b93b3e46892fe5c3</citedby><cites>FETCH-LOGICAL-c357t-fcd04d1f728ffe04aa91a375044911b3de320271d097bc204b93b3e46892fe5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-1119(96)00510-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8863740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scott, Ian C.</creatorcontrib><creatorcontrib>Halila, Ritva</creatorcontrib><creatorcontrib>Jenkins, Joanne M.</creatorcontrib><creatorcontrib>Mehan, Sharon</creatorcontrib><creatorcontrib>Apostolou, Sinoula</creatorcontrib><creatorcontrib>Winqvist, Robert</creatorcontrib><creatorcontrib>Callen, David F.</creatorcontrib><creatorcontrib>Prockop, Darwin J.</creatorcontrib><creatorcontrib>Peltonen, Leena</creatorcontrib><creatorcontrib>Kadler, Karl E.</creatorcontrib><title>Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)</title><title>Gene</title><addtitle>Gene</addtitle><description>The zincins are a superfamily of structurally-related Zn
2+-binding metallopeptidases which play a major role in a wide range of biological processes including pattern formation, growth factor activation and extracellular matrix synthesis and degradation. In this paper we report the identification and complete primary structure of a novel 33 kDa protein which contains the zinc-binding HEXXH motif found in the zincin superfamily. We have named this novel protein PRSM1 (PRoteaSe, Metallo, number 1). The gene was identified by the immunoscreening of a human placental cDNA library using polyclonal antibodies raised to the 70 kDa human matrix metalloendopeptidase, type III procollagen N-proteinase [Halila, R. and Peltonen, L. (1986) Purification of human procollagen type III N-proteinase from placenta and preparation of antiserum. Biochem. J. 239, 47–52]. The protein is found in placenta and cultured osteosarcoma cells.
PRSM1 could share sequence homology with the type III procollagen N-proteinase. The
prsml gene is represented once in the human genome and is localized on chromosome 16 (q24.3).</description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 16</subject><subject>Cloning, Molecular</subject><subject>Gluzincin</subject><subject>Humans</subject><subject>Immunoscreening</subject><subject>Metalloendopeptidase</subject><subject>Metalloendopeptidases - genetics</subject><subject>Metalloproteinase</subject><subject>Metzincin</subject><subject>Molecular Sequence Data</subject><subject>Primary structure</subject><subject>Recombinant protein</subject><subject>Sequence Alignment</subject><subject>Type III collagen</subject><subject>Type III procollagen N-proteinase</subject><subject>Zincin</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2P1SAUxYnRjM-n_4EmrMxMYvVSaCkbEzN-JjPR-LEmFG5nUFoqtBN14d8uzXuZpXdD7jmHQ_gR8pjBcwasfQFcdhVjTJ2q9gygYVDBHbJjnVQVAO_ukt1t5D55kPN3KNM09Qk56bqWSwE78vcyBrRrMInaECc_XT2j-GtOmLOPEzWTo_Y6xTHmOJpAQ7Qm-D9m2cw4UEOv19FM9AonpDjZ6EpDUTmnP14bOq9Lid4gHXExIcQZ58U7k5Gefvr85ZKdPST3BhMyPjqee_Lt7Zuv5--ri4_vPpy_uqgsb-RSDdaBcGyQdTcMCMIYxQyXDQihGOu5Q15DLZkDJXtbg-gV7zmKtlP1gI3le_L00Dun-HPFvOjRZ4shmAnjmrXsRN2KlpegOARtijknHPSc_GjSb81Ab9j1xlRvTLUqy4a9SHvy5Ni_9iO620tHzsV_efCxfPLGY9LZ-sILnU9oF-2i__8D_wAIYZHD</recordid><startdate>19960926</startdate><enddate>19960926</enddate><creator>Scott, Ian C.</creator><creator>Halila, Ritva</creator><creator>Jenkins, Joanne M.</creator><creator>Mehan, Sharon</creator><creator>Apostolou, Sinoula</creator><creator>Winqvist, Robert</creator><creator>Callen, David F.</creator><creator>Prockop, Darwin J.</creator><creator>Peltonen, Leena</creator><creator>Kadler, Karl E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960926</creationdate><title>Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)</title><author>Scott, Ian C. ; Halila, Ritva ; Jenkins, Joanne M. ; Mehan, Sharon ; Apostolou, Sinoula ; Winqvist, Robert ; Callen, David F. ; Prockop, Darwin J. ; Peltonen, Leena ; Kadler, Karl E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-fcd04d1f728ffe04aa91a375044911b3de320271d097bc204b93b3e46892fe5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 16</topic><topic>Cloning, Molecular</topic><topic>Gluzincin</topic><topic>Humans</topic><topic>Immunoscreening</topic><topic>Metalloendopeptidase</topic><topic>Metalloendopeptidases - genetics</topic><topic>Metalloproteinase</topic><topic>Metzincin</topic><topic>Molecular Sequence Data</topic><topic>Primary structure</topic><topic>Recombinant protein</topic><topic>Sequence Alignment</topic><topic>Type III collagen</topic><topic>Type III procollagen N-proteinase</topic><topic>Zincin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scott, Ian C.</creatorcontrib><creatorcontrib>Halila, Ritva</creatorcontrib><creatorcontrib>Jenkins, Joanne M.</creatorcontrib><creatorcontrib>Mehan, Sharon</creatorcontrib><creatorcontrib>Apostolou, Sinoula</creatorcontrib><creatorcontrib>Winqvist, Robert</creatorcontrib><creatorcontrib>Callen, David F.</creatorcontrib><creatorcontrib>Prockop, Darwin J.</creatorcontrib><creatorcontrib>Peltonen, Leena</creatorcontrib><creatorcontrib>Kadler, Karl E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scott, Ian C.</au><au>Halila, Ritva</au><au>Jenkins, Joanne M.</au><au>Mehan, Sharon</au><au>Apostolou, Sinoula</au><au>Winqvist, Robert</au><au>Callen, David F.</au><au>Prockop, Darwin J.</au><au>Peltonen, Leena</au><au>Kadler, Karl E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1996-09-26</date><risdate>1996</risdate><volume>174</volume><issue>1</issue><spage>135</spage><epage>143</epage><pages>135-143</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>The zincins are a superfamily of structurally-related Zn
2+-binding metallopeptidases which play a major role in a wide range of biological processes including pattern formation, growth factor activation and extracellular matrix synthesis and degradation. In this paper we report the identification and complete primary structure of a novel 33 kDa protein which contains the zinc-binding HEXXH motif found in the zincin superfamily. We have named this novel protein PRSM1 (PRoteaSe, Metallo, number 1). The gene was identified by the immunoscreening of a human placental cDNA library using polyclonal antibodies raised to the 70 kDa human matrix metalloendopeptidase, type III procollagen N-proteinase [Halila, R. and Peltonen, L. (1986) Purification of human procollagen type III N-proteinase from placenta and preparation of antiserum. Biochem. J. 239, 47–52]. The protein is found in placenta and cultured osteosarcoma cells.
PRSM1 could share sequence homology with the type III procollagen N-proteinase. The
prsml gene is represented once in the human genome and is localized on chromosome 16 (q24.3).</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8863740</pmid><doi>10.1016/0378-1119(96)00510-0</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Base Sequence Chromosome Mapping Chromosomes, Human, Pair 16 Cloning, Molecular Gluzincin Humans Immunoscreening Metalloendopeptidase Metalloendopeptidases - genetics Metalloproteinase Metzincin Molecular Sequence Data Primary structure Recombinant protein Sequence Alignment Type III collagen Type III procollagen N-proteinase Zincin |
| title | Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1) |
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