Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency

Cytokines that bind to the interleukin‐2 (IL‐2) receptor common gamma chain (γc), including IL‐2, IL‐4, IL‐7, IL‐9, and IL‐15, are important for the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monoctyes. These cytokines have overlapping biological effect...

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Veröffentlicht in:	Journal of leukocyte biology 1996-10, Vol.60 (4), p.441-452
Hauptverfasser:	Johnston, James A., Bacon, Chris M., Riedy, M. C., O'Shea, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Transformation, Neoplastic - genetics Chromosome Mapping cytokine signaling DNA-Binding Proteins - physiology Enzyme Precursors - physiology Genes Humans IL‐12 IL‐15 IL‐4 Interleukin-12 - physiology Interleukin-2 - physiology Intracellular Signaling Peptides and Proteins JAK3 Janus Janus Kinase 3 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Lymphocytes - physiology Phosphotyrosine - physiology Protein-Tyrosine Kinases - physiology receptor Receptors, Cytokine - physiology severe combined immunodeficiency Severe Combined Immunodeficiency - physiopathology Signal Transduction src Homology Domains src-Family Kinases - physiology STAT1 Transcription Factor STAT5 Syk Kinase Trans-Activators - physiology
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