Acoustically activated c- fos expression in auditory nuclei of the anaesthetised guinea pig
The spatial expression of the immediate-early gene c- fos in central auditory nuclei of the anaesthetised guinea pig was investigated following exposure of the animal to acoustic stimulation. Accurate control of both the spectra and the level of the stimulus was designed so that the presumed excitat...
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| Veröffentlicht in: | Brain research 1996-07, Vol.728 (1), p.72-78 |
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| creator | Cody, A.R. Wilson, W. Leah, J. |
| description | The spatial expression of the immediate-early gene c-
fos in central auditory nuclei of the anaesthetised guinea pig was investigated following exposure of the animal to acoustic stimulation. Accurate control of both the spectra and the level of the stimulus was designed so that the presumed excitation of central auditory nuclei was similar across animals. For unstimulated anaesthetised control animals, levels of labelling were significantly higher when compared with unanaesthetised controls. This appeared to be a result of the combination of the experimental manipulations and also the use of the anaesthetic. A surprising finding was that unstimulated control animals placed in an anechoic chamber demonstrated the highest levels of fos-like immunoreactivity (Fos-LIR). When anaesthetised animals were exposed to acoustic stimuli the total number of cells showing Fos-LIR was elevated when compared to anaesthetised, but unstimulated animals. There was no evidence at any level of the auditory pathway that these animals demonstrated spatially restricted Fos-LIR which may have suggested place-frequency mapping. In contrast, spatially restricted labelling was found in awake animals exposed to an identical stimulus. |
| doi_str_mv | 10.1016/0006-8993(96)00388-5 |
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fos in central auditory nuclei of the anaesthetised guinea pig was investigated following exposure of the animal to acoustic stimulation. Accurate control of both the spectra and the level of the stimulus was designed so that the presumed excitation of central auditory nuclei was similar across animals. For unstimulated anaesthetised control animals, levels of labelling were significantly higher when compared with unanaesthetised controls. This appeared to be a result of the combination of the experimental manipulations and also the use of the anaesthetic. A surprising finding was that unstimulated control animals placed in an anechoic chamber demonstrated the highest levels of fos-like immunoreactivity (Fos-LIR). When anaesthetised animals were exposed to acoustic stimuli the total number of cells showing Fos-LIR was elevated when compared to anaesthetised, but unstimulated animals. There was no evidence at any level of the auditory pathway that these animals demonstrated spatially restricted Fos-LIR which may have suggested place-frequency mapping. In contrast, spatially restricted labelling was found in awake animals exposed to an identical stimulus.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(96)00388-5</identifier><identifier>PMID: 8864299</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Anaesthetic ; Anechoic ; Anesthetics ; Animals ; Auditory ; Auditory Pathways - metabolism ; Biological and medical sciences ; Brain Mapping ; Brain Stem - metabolism ; c- fos ; Cell Count ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Fundamental and applied biological sciences. Psychology ; Guinea pig ; Guinea Pigs ; Halothane ; Immunohistochemistry ; Nerve Tissue Proteins - biosynthesis ; Proto-Oncogene Proteins c-fos - biosynthesis ; Reference Values ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1996-07, Vol.728 (1), p.72-78</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-6f6cb52f95d3c97ff80aebbd70b47bf4038c7ca00806d0d5219b220ccfdc9efa3</citedby><cites>FETCH-LOGICAL-c446t-6f6cb52f95d3c97ff80aebbd70b47bf4038c7ca00806d0d5219b220ccfdc9efa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(96)00388-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3169679$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8864299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cody, A.R.</creatorcontrib><creatorcontrib>Wilson, W.</creatorcontrib><creatorcontrib>Leah, J.</creatorcontrib><title>Acoustically activated c- fos expression in auditory nuclei of the anaesthetised guinea pig</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The spatial expression of the immediate-early gene c-
fos in central auditory nuclei of the anaesthetised guinea pig was investigated following exposure of the animal to acoustic stimulation. Accurate control of both the spectra and the level of the stimulus was designed so that the presumed excitation of central auditory nuclei was similar across animals. For unstimulated anaesthetised control animals, levels of labelling were significantly higher when compared with unanaesthetised controls. This appeared to be a result of the combination of the experimental manipulations and also the use of the anaesthetic. A surprising finding was that unstimulated control animals placed in an anechoic chamber demonstrated the highest levels of fos-like immunoreactivity (Fos-LIR). When anaesthetised animals were exposed to acoustic stimuli the total number of cells showing Fos-LIR was elevated when compared to anaesthetised, but unstimulated animals. There was no evidence at any level of the auditory pathway that these animals demonstrated spatially restricted Fos-LIR which may have suggested place-frequency mapping. In contrast, spatially restricted labelling was found in awake animals exposed to an identical stimulus.</description><subject>Acoustic Stimulation</subject><subject>Anaesthetic</subject><subject>Anechoic</subject><subject>Anesthetics</subject><subject>Animals</subject><subject>Auditory</subject><subject>Auditory Pathways - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Brain Stem - metabolism</subject><subject>c- fos</subject><subject>Cell Count</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea pig</subject><subject>Guinea Pigs</subject><subject>Halothane</subject><subject>Immunohistochemistry</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Reference Values</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAQhkVpSTZp36ABHUpIDk7Hsi1Ll0IISVoI5NKeehDyaJSqeO2NZIfu20dmlz2mJ2mY7x9mPsY-l3BVQim_AoAslNbVhZaXAJVSRfOOrUrVikKKGt6z1QE5Zicp_c1lVWk4YkdKyVpovWK_r3Gc0xTQ9v2WW5zCi53IcSy4HxOnf5tIKYVx4GHgdnZhGuOWDzP2FPjo-fSHuB0spfyZQsrJpzkMZPkmPH1kH7ztE33av6fs193tz5vvxcPj_Y-b64cC61pOhfQSu0Z43bgKdeu9Aktd51ro6rbzdb4MW7QACqQD14hSd0IAoneoydvqlJ3v5m7i-DznVcw6JKS-twPl40yralEJKf4Llk22IvQC1jsQ45hSJG82Maxt3JoSzCLfLGbNYtbopcjyTZNjZ_v5c7cmdwjtbef-l33fpizcRztgSAesKqWW7YJ922GUpb0EiiZhoAHJhUg4GTeGt_d4BaVtoZI</recordid><startdate>19960722</startdate><enddate>19960722</enddate><creator>Cody, A.R.</creator><creator>Wilson, W.</creator><creator>Leah, J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19960722</creationdate><title>Acoustically activated c- fos expression in auditory nuclei of the anaesthetised guinea pig</title><author>Cody, A.R. ; Wilson, W. ; Leah, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-6f6cb52f95d3c97ff80aebbd70b47bf4038c7ca00806d0d5219b220ccfdc9efa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acoustic Stimulation</topic><topic>Anaesthetic</topic><topic>Anechoic</topic><topic>Anesthetics</topic><topic>Animals</topic><topic>Auditory</topic><topic>Auditory Pathways - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Brain Stem - metabolism</topic><topic>c- fos</topic><topic>Cell Count</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea pig</topic><topic>Guinea Pigs</topic><topic>Halothane</topic><topic>Immunohistochemistry</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Proto-Oncogene Proteins c-fos - biosynthesis</topic><topic>Reference Values</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cody, A.R.</creatorcontrib><creatorcontrib>Wilson, W.</creatorcontrib><creatorcontrib>Leah, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cody, A.R.</au><au>Wilson, W.</au><au>Leah, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acoustically activated c- fos expression in auditory nuclei of the anaesthetised guinea pig</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1996-07-22</date><risdate>1996</risdate><volume>728</volume><issue>1</issue><spage>72</spage><epage>78</epage><pages>72-78</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The spatial expression of the immediate-early gene c-
fos in central auditory nuclei of the anaesthetised guinea pig was investigated following exposure of the animal to acoustic stimulation. Accurate control of both the spectra and the level of the stimulus was designed so that the presumed excitation of central auditory nuclei was similar across animals. For unstimulated anaesthetised control animals, levels of labelling were significantly higher when compared with unanaesthetised controls. This appeared to be a result of the combination of the experimental manipulations and also the use of the anaesthetic. A surprising finding was that unstimulated control animals placed in an anechoic chamber demonstrated the highest levels of fos-like immunoreactivity (Fos-LIR). When anaesthetised animals were exposed to acoustic stimuli the total number of cells showing Fos-LIR was elevated when compared to anaesthetised, but unstimulated animals. There was no evidence at any level of the auditory pathway that these animals demonstrated spatially restricted Fos-LIR which may have suggested place-frequency mapping. In contrast, spatially restricted labelling was found in awake animals exposed to an identical stimulus.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8864299</pmid><doi>10.1016/0006-8993(96)00388-5</doi><tpages>7</tpages></addata></record> |
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| subjects | Acoustic Stimulation Anaesthetic Anechoic Anesthetics Animals Auditory Auditory Pathways - metabolism Biological and medical sciences Brain Mapping Brain Stem - metabolism c- fos Cell Count Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Fundamental and applied biological sciences. Psychology Guinea pig Guinea Pigs Halothane Immunohistochemistry Nerve Tissue Proteins - biosynthesis Proto-Oncogene Proteins c-fos - biosynthesis Reference Values Vertebrates: nervous system and sense organs |
| title | Acoustically activated c- fos expression in auditory nuclei of the anaesthetised guinea pig |
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