The role of glycation cross-links in diabetic vascular stiffening

Previous studies have shown that biomechanical analysis of aorta from diabetic subjects reveals a marked increase in stiffness compared to aorta from age-matched control subjects. In the present paper we have proposed that this increased stiffness can be attributed to glycation-induced inter-molecul...

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Veröffentlicht in:	Diabetologia 1996-08, Vol.39 (8), p.946-951
Hauptverfasser:	Sims, T J, Rasmussen, L M, Oxlund, H, Bailey, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging - metabolism Aging - pathology Amino Acids - analysis Aorta, Thoracic - chemistry Aorta, Thoracic - pathology Arginine - analogs & derivatives Arginine - chemistry Arginine - metabolism Collagen - analysis Cross-Linking Reagents - chemistry Cross-Linking Reagents - metabolism Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Diabetic Angiopathies - metabolism Elastin - analysis Glycation End Products, Advanced - analysis Glycation End Products, Advanced - chemistry Glycation End Products, Advanced - metabolism Humans Lysine - analogs & derivatives Lysine - chemistry Lysine - metabolism Middle Aged Time Factors
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