A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube

The site of integration of transgenes in the host genome can affect levels of expression and occasionally confer ectopic patterns of expression on otherwise tissue-specific genes. We describe here a line of mice in which an hsp68-lacZ transgene is expressed in unstressed developing neural tissue and...

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Veröffentlicht in:	Nature (London) 1988-09, Vol.335 (6189), p.435-437
Hauptverfasser:	Kothary, R, Clapoff, S, Brown, A, Campbell, R, Peterson, A, Rossant, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase - biosynthesis beta-Galactosidase - genetics Central Nervous System - embryology Central Nervous System - metabolism Crosses, Genetic DNA Dystonia - genetics Genetics Lac Operon Mice Mice, Transgenic Mutation Nervous system Regulatory Sequences, Nucleic Acid Rodents Tissues
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