Near tetraploid prostate carcinoma: Methodologic and prognostic aspects
BACKGROUND The clinical value of DNA ploidy analysis in prostate carcinoma has been an issue for investigation for more than 2 decades. In general, diploid or pseudodiploid tumors are associated with a favorable prognosis and aneuploid tumors with an unfavorable prognosis, irrespective of type of tr...
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| Veröffentlicht in: | Cancer 1996-10, Vol.78 (8), p.1748-1755 |
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| creator | Forsslund, Gun Nilsson, Bo Zetterberg, Anders |
| description | BACKGROUND
The clinical value of DNA ploidy analysis in prostate carcinoma has been an issue for investigation for more than 2 decades. In general, diploid or pseudodiploid tumors are associated with a favorable prognosis and aneuploid tumors with an unfavorable prognosis, irrespective of type of treatment. Tumors with DNA values in the tetraploid region (around 4c) present a diagnostic problem. Such DNA distributions may clearly represent aneuploid tumors with an unfavorable prognosis. However, a 4c distribution may conversely represent a tetraploid tumor (possibly a polyploid variant of the diploid tumor) with a favorable prognosis. Previous data from our laboratory indicate the existence of such a tetraploid subgroup. The goal of the current study was to investigate the diagnostic problem of 4c tumors in greater detail.
METHODS
Ploidy classification of cytologic smears by image cytometry was performed in a retrospective study of 334 patients with hormonally treated prostate carcinoma. Follow‐up time was 30 years or until death.
RESULTS
Three ploidy types were defined: near‐diploid (D type), near‐tetraploid (T type), and highly aneuploid (A type). Tumors with a modal value within the tetraploid region were found in 27% (92 cases) of the total material. Of these, 9% were defined as T type and 18% as A type. Overall, 37% of the tumors were classified as D type, 9% as T type, and 54% as A type. Of the A type tumors, one‐third had modal DNA values in the tetraploid (4c) region. Multivariate analysis showed a statistically significant difference between A type tumors and D and T type, but not between D type and T type. Both D and T type tumors progressed slowly and killed the patients 5 to 30 years after diagnosis, whereas A type tumors progressed rapidly and killed the patients within 6 years of diagnosis.
CONCLUSIONS
By image cytometry, prostate carcinoma can be divided into three ploidy types: D, T, and A type. Biologically, however, the tumors fall into only two groups: low grade malignant, pseudodiploid tumors of D or T type, and high grade malignant, highly aneuploid tumors of A type. Cancer 1996;78:1748‐55. |
| doi_str_mv | 10.1002/(SICI)1097-0142(19961015)78:8<1748::AID-CNCR15>3.0.CO;2-Y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78418394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78418394</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3165-6b61ec71da6eee3a3696d1c6a5db37a71a6d843137d7c6854ab28bdcc5f202753</originalsourceid><addsrcrecordid>eNqFkF1r2zAUhsXY6NJ2P2HgizHaC2f6sD6cjUHw2i7QNbAPWNjF4VhSOhfHziyH0n8_efFys0GvxNF59PLqIWTO6JRRyt-cfVkUi3NGc51SlvEzlueKUSbPtZmZd0xnZjabLz6kxU3xmcn3YkqnxfItT1dPyOTw6imZUEpNKjPx_Tk5DuEujppLcUSOjJE5M2ZCrm48dknv-w63dVu5ZNu1ocfeJxY7WzXtBmfJJ9__bF1bt7eVTbD5A902kRvGsPW2D6fk2Rrr4F-M5wn5dnnxtfiYXi-vFsX8OrWCKZmqUjFvNXOovPcChcqVY1ahdKXQqBkqZzLBhHbaKiMzLLkpnbVyzSnXUpyQ1_vcWOHXzoceNlWwvq6x8e0ugDYZMyLPIrjagzZ-KHR-Dduu2mD3AIzCIBlgkAyDLhh0wV_JMQMMDJIBomTYSwYBFIolcFjF7JdjiV258e6QPFqN-1fjHoPFet1hY6twwAQXmmc6Yj_22H1V-4d_-j1e77_txhvxG-HlplA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78418394</pqid></control><display><type>article</type><title>Near tetraploid prostate carcinoma: Methodologic and prognostic aspects</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><creator>Forsslund, Gun ; Nilsson, Bo ; Zetterberg, Anders</creator><creatorcontrib>Forsslund, Gun ; Nilsson, Bo ; Zetterberg, Anders</creatorcontrib><description>BACKGROUND
The clinical value of DNA ploidy analysis in prostate carcinoma has been an issue for investigation for more than 2 decades. In general, diploid or pseudodiploid tumors are associated with a favorable prognosis and aneuploid tumors with an unfavorable prognosis, irrespective of type of treatment. Tumors with DNA values in the tetraploid region (around 4c) present a diagnostic problem. Such DNA distributions may clearly represent aneuploid tumors with an unfavorable prognosis. However, a 4c distribution may conversely represent a tetraploid tumor (possibly a polyploid variant of the diploid tumor) with a favorable prognosis. Previous data from our laboratory indicate the existence of such a tetraploid subgroup. The goal of the current study was to investigate the diagnostic problem of 4c tumors in greater detail.
METHODS
Ploidy classification of cytologic smears by image cytometry was performed in a retrospective study of 334 patients with hormonally treated prostate carcinoma. Follow‐up time was 30 years or until death.
RESULTS
Three ploidy types were defined: near‐diploid (D type), near‐tetraploid (T type), and highly aneuploid (A type). Tumors with a modal value within the tetraploid region were found in 27% (92 cases) of the total material. Of these, 9% were defined as T type and 18% as A type. Overall, 37% of the tumors were classified as D type, 9% as T type, and 54% as A type. Of the A type tumors, one‐third had modal DNA values in the tetraploid (4c) region. Multivariate analysis showed a statistically significant difference between A type tumors and D and T type, but not between D type and T type. Both D and T type tumors progressed slowly and killed the patients 5 to 30 years after diagnosis, whereas A type tumors progressed rapidly and killed the patients within 6 years of diagnosis.
CONCLUSIONS
By image cytometry, prostate carcinoma can be divided into three ploidy types: D, T, and A type. Biologically, however, the tumors fall into only two groups: low grade malignant, pseudodiploid tumors of D or T type, and high grade malignant, highly aneuploid tumors of A type. Cancer 1996;78:1748‐55.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/(SICI)1097-0142(19961015)78:8<1748::AID-CNCR15>3.0.CO;2-Y</identifier><identifier>PMID: 8859188</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Carcinoma - genetics ; Carcinoma - mortality ; Carcinoma - pathology ; DNA ploidy ; DNA, Neoplasm - isolation & purification ; Follow-Up Studies ; hormonal treatment ; Humans ; Image Cytometry ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Ploidies ; Prognosis ; Proportional Hazards Models ; prostate carcinoma ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Retrospective Studies ; Survival Analysis ; tetraploid tumors ; Time Factors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>Cancer, 1996-10, Vol.78 (8), p.1748-1755</ispartof><rights>Copyright © 1996 American Cancer Society</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3165-6b61ec71da6eee3a3696d1c6a5db37a71a6d843137d7c6854ab28bdcc5f202753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0142%2819961015%2978%3A8%3C1748%3A%3AAID-CNCR15%3E3.0.CO%3B2-Y$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0142%2819961015%2978%3A8%3C1748%3A%3AAID-CNCR15%3E3.0.CO%3B2-Y$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3237247$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8859188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forsslund, Gun</creatorcontrib><creatorcontrib>Nilsson, Bo</creatorcontrib><creatorcontrib>Zetterberg, Anders</creatorcontrib><title>Near tetraploid prostate carcinoma: Methodologic and prognostic aspects</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
The clinical value of DNA ploidy analysis in prostate carcinoma has been an issue for investigation for more than 2 decades. In general, diploid or pseudodiploid tumors are associated with a favorable prognosis and aneuploid tumors with an unfavorable prognosis, irrespective of type of treatment. Tumors with DNA values in the tetraploid region (around 4c) present a diagnostic problem. Such DNA distributions may clearly represent aneuploid tumors with an unfavorable prognosis. However, a 4c distribution may conversely represent a tetraploid tumor (possibly a polyploid variant of the diploid tumor) with a favorable prognosis. Previous data from our laboratory indicate the existence of such a tetraploid subgroup. The goal of the current study was to investigate the diagnostic problem of 4c tumors in greater detail.
METHODS
Ploidy classification of cytologic smears by image cytometry was performed in a retrospective study of 334 patients with hormonally treated prostate carcinoma. Follow‐up time was 30 years or until death.
RESULTS
Three ploidy types were defined: near‐diploid (D type), near‐tetraploid (T type), and highly aneuploid (A type). Tumors with a modal value within the tetraploid region were found in 27% (92 cases) of the total material. Of these, 9% were defined as T type and 18% as A type. Overall, 37% of the tumors were classified as D type, 9% as T type, and 54% as A type. Of the A type tumors, one‐third had modal DNA values in the tetraploid (4c) region. Multivariate analysis showed a statistically significant difference between A type tumors and D and T type, but not between D type and T type. Both D and T type tumors progressed slowly and killed the patients 5 to 30 years after diagnosis, whereas A type tumors progressed rapidly and killed the patients within 6 years of diagnosis.
CONCLUSIONS
By image cytometry, prostate carcinoma can be divided into three ploidy types: D, T, and A type. Biologically, however, the tumors fall into only two groups: low grade malignant, pseudodiploid tumors of D or T type, and high grade malignant, highly aneuploid tumors of A type. Cancer 1996;78:1748‐55.</description><subject>Biological and medical sciences</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>DNA ploidy</subject><subject>DNA, Neoplasm - isolation & purification</subject><subject>Follow-Up Studies</subject><subject>hormonal treatment</subject><subject>Humans</subject><subject>Image Cytometry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Ploidies</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>prostate carcinoma</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>tetraploid tumors</subject><subject>Time Factors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1r2zAUhsXY6NJ2P2HgizHaC2f6sD6cjUHw2i7QNbAPWNjF4VhSOhfHziyH0n8_efFys0GvxNF59PLqIWTO6JRRyt-cfVkUi3NGc51SlvEzlueKUSbPtZmZd0xnZjabLz6kxU3xmcn3YkqnxfItT1dPyOTw6imZUEpNKjPx_Tk5DuEujppLcUSOjJE5M2ZCrm48dknv-w63dVu5ZNu1ocfeJxY7WzXtBmfJJ9__bF1bt7eVTbD5A902kRvGsPW2D6fk2Rrr4F-M5wn5dnnxtfiYXi-vFsX8OrWCKZmqUjFvNXOovPcChcqVY1ahdKXQqBkqZzLBhHbaKiMzLLkpnbVyzSnXUpyQ1_vcWOHXzoceNlWwvq6x8e0ugDYZMyLPIrjagzZ-KHR-Dduu2mD3AIzCIBlgkAyDLhh0wV_JMQMMDJIBomTYSwYBFIolcFjF7JdjiV258e6QPFqN-1fjHoPFet1hY6twwAQXmmc6Yj_22H1V-4d_-j1e77_txhvxG-HlplA</recordid><startdate>19961015</startdate><enddate>19961015</enddate><creator>Forsslund, Gun</creator><creator>Nilsson, Bo</creator><creator>Zetterberg, Anders</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961015</creationdate><title>Near tetraploid prostate carcinoma: Methodologic and prognostic aspects</title><author>Forsslund, Gun ; Nilsson, Bo ; Zetterberg, Anders</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3165-6b61ec71da6eee3a3696d1c6a5db37a71a6d843137d7c6854ab28bdcc5f202753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>DNA ploidy</topic><topic>DNA, Neoplasm - isolation & purification</topic><topic>Follow-Up Studies</topic><topic>hormonal treatment</topic><topic>Humans</topic><topic>Image Cytometry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Ploidies</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>prostate carcinoma</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>tetraploid tumors</topic><topic>Time Factors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forsslund, Gun</creatorcontrib><creatorcontrib>Nilsson, Bo</creatorcontrib><creatorcontrib>Zetterberg, Anders</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forsslund, Gun</au><au>Nilsson, Bo</au><au>Zetterberg, Anders</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Near tetraploid prostate carcinoma: Methodologic and prognostic aspects</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1996-10-15</date><risdate>1996</risdate><volume>78</volume><issue>8</issue><spage>1748</spage><epage>1755</epage><pages>1748-1755</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
The clinical value of DNA ploidy analysis in prostate carcinoma has been an issue for investigation for more than 2 decades. In general, diploid or pseudodiploid tumors are associated with a favorable prognosis and aneuploid tumors with an unfavorable prognosis, irrespective of type of treatment. Tumors with DNA values in the tetraploid region (around 4c) present a diagnostic problem. Such DNA distributions may clearly represent aneuploid tumors with an unfavorable prognosis. However, a 4c distribution may conversely represent a tetraploid tumor (possibly a polyploid variant of the diploid tumor) with a favorable prognosis. Previous data from our laboratory indicate the existence of such a tetraploid subgroup. The goal of the current study was to investigate the diagnostic problem of 4c tumors in greater detail.
METHODS
Ploidy classification of cytologic smears by image cytometry was performed in a retrospective study of 334 patients with hormonally treated prostate carcinoma. Follow‐up time was 30 years or until death.
RESULTS
Three ploidy types were defined: near‐diploid (D type), near‐tetraploid (T type), and highly aneuploid (A type). Tumors with a modal value within the tetraploid region were found in 27% (92 cases) of the total material. Of these, 9% were defined as T type and 18% as A type. Overall, 37% of the tumors were classified as D type, 9% as T type, and 54% as A type. Of the A type tumors, one‐third had modal DNA values in the tetraploid (4c) region. Multivariate analysis showed a statistically significant difference between A type tumors and D and T type, but not between D type and T type. Both D and T type tumors progressed slowly and killed the patients 5 to 30 years after diagnosis, whereas A type tumors progressed rapidly and killed the patients within 6 years of diagnosis.
CONCLUSIONS
By image cytometry, prostate carcinoma can be divided into three ploidy types: D, T, and A type. Biologically, however, the tumors fall into only two groups: low grade malignant, pseudodiploid tumors of D or T type, and high grade malignant, highly aneuploid tumors of A type. Cancer 1996;78:1748‐55.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8859188</pmid><doi>10.1002/(SICI)1097-0142(19961015)78:8<1748::AID-CNCR15>3.0.CO;2-Y</doi><tpages>8</tpages></addata></record> |
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| subjects | Biological and medical sciences Carcinoma - genetics Carcinoma - mortality Carcinoma - pathology DNA ploidy DNA, Neoplasm - isolation & purification Follow-Up Studies hormonal treatment Humans Image Cytometry Male Medical sciences Nephrology. Urinary tract diseases Ploidies Prognosis Proportional Hazards Models prostate carcinoma Prostatic Neoplasms - genetics Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Retrospective Studies Survival Analysis tetraploid tumors Time Factors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Near tetraploid prostate carcinoma: Methodologic and prognostic aspects |
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