Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease : Biochemical and ultrasonic studies in the first trimester of pregnancy
Our purpose was to investigate early biochemical and ultrasonic measurements of pregnancies resulting from embryos biopsied for preimplantation diagnosis of inherited disease. Singleton pregnancies following biopsy had lower initial hCG levels [10 or 12 days after oocyte recovery (OR)], which rose s...
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Veröffentlicht in: | Journal of assisted reproduction and genetics 1996-03, Vol.13 (3), p.254-258 |
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container_title | Journal of assisted reproduction and genetics |
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creator | SOUSSIS, I HARPER, J. C KONTOGIANNI, E PARASCHOS, T PACKHAM, D HANDYSIDE, A. H WINSTON, R. M. L |
description | Our purpose was to investigate early biochemical and ultrasonic measurements of pregnancies resulting from embryos biopsied for preimplantation diagnosis of inherited disease.
Singleton pregnancies following biopsy had lower initial hCG levels [10 or 12 days after oocyte recovery (OR)], which rose steeply to match the controls by 16 days after OR. Twin biopsied pregnancies showed hCG levels lower than those of twin control pregnancies, which rose in parallel with the controls but remained lower for a longer period than the singletons. Progesterone levels showed a wide variation. Ultrasound measurements showed that overall the mean sac diameter and crown-rump length at 28 and 42 days after egg collection were similar in biopsied and control pregnancies.
Pregnancies resulting from biopsied embryos behave similarly to control IVF pregnancies. However, the reduction in cell mass following embryo biopsy occasionally results in reduced levels of circulating serum hCG and smaller ultrasound measurements in early pregnancy. |
doi_str_mv | 10.1007/BF02065946 |
format | Article |
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Singleton pregnancies following biopsy had lower initial hCG levels [10 or 12 days after oocyte recovery (OR)], which rose steeply to match the controls by 16 days after OR. Twin biopsied pregnancies showed hCG levels lower than those of twin control pregnancies, which rose in parallel with the controls but remained lower for a longer period than the singletons. Progesterone levels showed a wide variation. Ultrasound measurements showed that overall the mean sac diameter and crown-rump length at 28 and 42 days after egg collection were similar in biopsied and control pregnancies.
Pregnancies resulting from biopsied embryos behave similarly to control IVF pregnancies. However, the reduction in cell mass following embryo biopsy occasionally results in reduced levels of circulating serum hCG and smaller ultrasound measurements in early pregnancy.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/BF02065946</identifier><identifier>PMID: 8852889</identifier><identifier>CODEN: JARGE4</identifier><language>eng</language><publisher>New York, NY: Kluwer/Plenum</publisher><subject>Biological and medical sciences ; Biopsy - adverse effects ; Birth control ; Blastocyst - metabolism ; Chorionic Gonadotropin - blood ; Embryo Transfer ; Female ; Fertilization in Vitro ; Genetic Diseases, Inborn - diagnosis ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Pregnancy ; Progesterone - blood ; Sterility. Assisted procreation ; Ultrasonography, Prenatal</subject><ispartof>Journal of assisted reproduction and genetics, 1996-03, Vol.13 (3), p.254-258</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-e960d1732c25fb2c62e80bc3d28c03381ebd98fd3778046b2c391ab47c9ea9f93</citedby><cites>FETCH-LOGICAL-c311t-e960d1732c25fb2c62e80bc3d28c03381ebd98fd3778046b2c391ab47c9ea9f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3024085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8852889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SOUSSIS, I</creatorcontrib><creatorcontrib>HARPER, J. C</creatorcontrib><creatorcontrib>KONTOGIANNI, E</creatorcontrib><creatorcontrib>PARASCHOS, T</creatorcontrib><creatorcontrib>PACKHAM, D</creatorcontrib><creatorcontrib>HANDYSIDE, A. H</creatorcontrib><creatorcontrib>WINSTON, R. M. L</creatorcontrib><title>Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease : Biochemical and ultrasonic studies in the first trimester of pregnancy</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><description>Our purpose was to investigate early biochemical and ultrasonic measurements of pregnancies resulting from embryos biopsied for preimplantation diagnosis of inherited disease.
Singleton pregnancies following biopsy had lower initial hCG levels [10 or 12 days after oocyte recovery (OR)], which rose steeply to match the controls by 16 days after OR. Twin biopsied pregnancies showed hCG levels lower than those of twin control pregnancies, which rose in parallel with the controls but remained lower for a longer period than the singletons. Progesterone levels showed a wide variation. Ultrasound measurements showed that overall the mean sac diameter and crown-rump length at 28 and 42 days after egg collection were similar in biopsied and control pregnancies.
Pregnancies resulting from biopsied embryos behave similarly to control IVF pregnancies. However, the reduction in cell mass following embryo biopsy occasionally results in reduced levels of circulating serum hCG and smaller ultrasound measurements in early pregnancy.</description><subject>Biological and medical sciences</subject><subject>Biopsy - adverse effects</subject><subject>Birth control</subject><subject>Blastocyst - metabolism</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Genetic Diseases, Inborn - diagnosis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Progesterone - blood</subject><subject>Sterility. Assisted procreation</subject><subject>Ultrasonography, Prenatal</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1TAQhSMEKm1hwx7JC8SiUsA_SWyzaysKSJVgAevIsce3RokdPM7iPhDvia8alZVHnk9nzsxpmjeMfmCUyo83d5TTodfd8Kw5Z70UrRSCPq817VVLu0G9bC4Qf1NKteLirDlTqudK6fPm748Mh2iiDYAkA25zCfFAfE4LgWXKx4RkCmnFAI74lMmaISzrbGIxJaRIXDCHmDAgSZ4cIEIJtn4iGATyidyEZB9gCdbMxERHqn42mGKFsGzuNDVEUh6A-JCxkJLDAlggn-TW3dvxVfPCmxnh9f5eNr_uPv-8_dref__y7fb6vrWCsdKCHqhjUnDLez9xO3BQdLLCcWWpEIrB5LTyTkip6lUqITQzUyetBqO9FpfN-0fdNac_W_UxLgEtzHVdSBuOUnVM6l5V8OoRtDkhZvDjWo2bfBwZHU-ZjP8zqfDbXXWbFnBP6B5C7b_b-wbrnXw-xYFPmKC8o6oX_wBJIJeI</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>SOUSSIS, I</creator><creator>HARPER, J. C</creator><creator>KONTOGIANNI, E</creator><creator>PARASCHOS, T</creator><creator>PACKHAM, D</creator><creator>HANDYSIDE, A. H</creator><creator>WINSTON, R. M. L</creator><general>Kluwer/Plenum</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease : Biochemical and ultrasonic studies in the first trimester of pregnancy</title><author>SOUSSIS, I ; HARPER, J. C ; KONTOGIANNI, E ; PARASCHOS, T ; PACKHAM, D ; HANDYSIDE, A. H ; WINSTON, R. M. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-e960d1732c25fb2c62e80bc3d28c03381ebd98fd3778046b2c391ab47c9ea9f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy - adverse effects</topic><topic>Birth control</topic><topic>Blastocyst - metabolism</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Genetic Diseases, Inborn - diagnosis</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Progesterone - blood</topic><topic>Sterility. Assisted procreation</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SOUSSIS, I</creatorcontrib><creatorcontrib>HARPER, J. C</creatorcontrib><creatorcontrib>KONTOGIANNI, E</creatorcontrib><creatorcontrib>PARASCHOS, T</creatorcontrib><creatorcontrib>PACKHAM, D</creatorcontrib><creatorcontrib>HANDYSIDE, A. H</creatorcontrib><creatorcontrib>WINSTON, R. M. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SOUSSIS, I</au><au>HARPER, J. C</au><au>KONTOGIANNI, E</au><au>PARASCHOS, T</au><au>PACKHAM, D</au><au>HANDYSIDE, A. H</au><au>WINSTON, R. M. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease : Biochemical and ultrasonic studies in the first trimester of pregnancy</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><addtitle>J Assist Reprod Genet</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>13</volume><issue>3</issue><spage>254</spage><epage>258</epage><pages>254-258</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><coden>JARGE4</coden><abstract>Our purpose was to investigate early biochemical and ultrasonic measurements of pregnancies resulting from embryos biopsied for preimplantation diagnosis of inherited disease.
Singleton pregnancies following biopsy had lower initial hCG levels [10 or 12 days after oocyte recovery (OR)], which rose steeply to match the controls by 16 days after OR. Twin biopsied pregnancies showed hCG levels lower than those of twin control pregnancies, which rose in parallel with the controls but remained lower for a longer period than the singletons. Progesterone levels showed a wide variation. Ultrasound measurements showed that overall the mean sac diameter and crown-rump length at 28 and 42 days after egg collection were similar in biopsied and control pregnancies.
Pregnancies resulting from biopsied embryos behave similarly to control IVF pregnancies. However, the reduction in cell mass following embryo biopsy occasionally results in reduced levels of circulating serum hCG and smaller ultrasound measurements in early pregnancy.</abstract><cop>New York, NY</cop><pub>Kluwer/Plenum</pub><pmid>8852889</pmid><doi>10.1007/BF02065946</doi><tpages>5</tpages></addata></record> |
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source | MEDLINE; Springer Online Journals Complete |
subjects | Biological and medical sciences Biopsy - adverse effects Birth control Blastocyst - metabolism Chorionic Gonadotropin - blood Embryo Transfer Female Fertilization in Vitro Genetic Diseases, Inborn - diagnosis Gynecology. Andrology. Obstetrics Humans Medical sciences Pregnancy Progesterone - blood Sterility. Assisted procreation Ultrasonography, Prenatal |
title | Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease : Biochemical and ultrasonic studies in the first trimester of pregnancy |
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