Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease : Biochemical and ultrasonic studies in the first trimester of pregnancy

Our purpose was to investigate early biochemical and ultrasonic measurements of pregnancies resulting from embryos biopsied for preimplantation diagnosis of inherited disease. Singleton pregnancies following biopsy had lower initial hCG levels [10 or 12 days after oocyte recovery (OR)], which rose s...

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Veröffentlicht in:Journal of assisted reproduction and genetics 1996-03, Vol.13 (3), p.254-258
Hauptverfasser: SOUSSIS, I, HARPER, J. C, KONTOGIANNI, E, PARASCHOS, T, PACKHAM, D, HANDYSIDE, A. H, WINSTON, R. M. L
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container_end_page 258
container_issue 3
container_start_page 254
container_title Journal of assisted reproduction and genetics
container_volume 13
creator SOUSSIS, I
HARPER, J. C
KONTOGIANNI, E
PARASCHOS, T
PACKHAM, D
HANDYSIDE, A. H
WINSTON, R. M. L
description Our purpose was to investigate early biochemical and ultrasonic measurements of pregnancies resulting from embryos biopsied for preimplantation diagnosis of inherited disease. Singleton pregnancies following biopsy had lower initial hCG levels [10 or 12 days after oocyte recovery (OR)], which rose steeply to match the controls by 16 days after OR. Twin biopsied pregnancies showed hCG levels lower than those of twin control pregnancies, which rose in parallel with the controls but remained lower for a longer period than the singletons. Progesterone levels showed a wide variation. Ultrasound measurements showed that overall the mean sac diameter and crown-rump length at 28 and 42 days after egg collection were similar in biopsied and control pregnancies. Pregnancies resulting from biopsied embryos behave similarly to control IVF pregnancies. However, the reduction in cell mass following embryo biopsy occasionally results in reduced levels of circulating serum hCG and smaller ultrasound measurements in early pregnancy.
doi_str_mv 10.1007/BF02065946
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source MEDLINE; Springer Online Journals Complete
subjects Biological and medical sciences
Biopsy - adverse effects
Birth control
Blastocyst - metabolism
Chorionic Gonadotropin - blood
Embryo Transfer
Female
Fertilization in Vitro
Genetic Diseases, Inborn - diagnosis
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Pregnancy
Progesterone - blood
Sterility. Assisted procreation
Ultrasonography, Prenatal
title Pregnancies resulting from embryos biopsied for preimplantation diagnosis of genetic disease : Biochemical and ultrasonic studies in the first trimester of pregnancy
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