CUTANEOUS LEISHMANIASIS: SCHEDULES FOR INTRALESIONAL TREATMENT WITH SODIUM STIBOGLUCONATE
Background. Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been i...
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| Veröffentlicht in: | International journal of dermatology 1996-08, Vol.35 (8), p.594-597 |
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| container_title | International journal of dermatology |
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| creator | TALLAB, TALAL M. BAHAMDAM, KHALID A. MIRDAD, SOLEMAN JOHARGI, HANAN MOURAD, MOHAMED MAZE IBRAHIM, KARAM EL SHERBINI, ABDUL HAMEED KARKASHAN, EMAN KHARE, ASHOK KUMAR JAMAL, AWATIF |
| description | Background. Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated.
Methods. Ninety‐six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule.
Results. The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate‐day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%.
Conclusions. Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments. |
| doi_str_mv | 10.1111/j.1365-4362.1996.tb03669.x |
| format | Article |
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Methods. Ninety‐six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule.
Results. The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate‐day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%.
Conclusions. Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/j.1365-4362.1996.tb03669.x</identifier><identifier>PMID: 8854166</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Antimony Sodium Gluconate - administration & dosage ; Antiprotozoal Agents - administration & dosage ; Biological and medical sciences ; Child ; Child, Preschool ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Human protozoal diseases ; Humans ; Infectious diseases ; Injections, Intradermal ; Injections, Intralesional ; Leishmaniasis, Cutaneous - drug therapy ; Leshmaniasis ; Male ; Medical sciences ; Middle Aged ; Parasitic diseases ; Protozoal diseases ; Remission Induction ; Treatment Outcome ; Tropical medicine</subject><ispartof>International journal of dermatology, 1996-08, Vol.35 (8), p.594-597</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4364-501cc6bead8a6ec65c1e8c5b9f37c985d0803f18e5eba4d89d49f5ed3a48d02c3</citedby><cites>FETCH-LOGICAL-c4364-501cc6bead8a6ec65c1e8c5b9f37c985d0803f18e5eba4d89d49f5ed3a48d02c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-4362.1996.tb03669.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-4362.1996.tb03669.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3181106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8854166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TALLAB, TALAL M.</creatorcontrib><creatorcontrib>BAHAMDAM, KHALID A.</creatorcontrib><creatorcontrib>MIRDAD, SOLEMAN</creatorcontrib><creatorcontrib>JOHARGI, HANAN</creatorcontrib><creatorcontrib>MOURAD, MOHAMED MAZE</creatorcontrib><creatorcontrib>IBRAHIM, KARAM</creatorcontrib><creatorcontrib>EL SHERBINI, ABDUL HAMEED</creatorcontrib><creatorcontrib>KARKASHAN, EMAN</creatorcontrib><creatorcontrib>KHARE, ASHOK KUMAR</creatorcontrib><creatorcontrib>JAMAL, AWATIF</creatorcontrib><title>CUTANEOUS LEISHMANIASIS: SCHEDULES FOR INTRALESIONAL TREATMENT WITH SODIUM STIBOGLUCONATE</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background. Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated.
Methods. Ninety‐six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule.
Results. The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate‐day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%.
Conclusions. Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antimony Sodium Gluconate - administration & dosage</subject><subject>Antiprotozoal Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Injections, Intradermal</subject><subject>Injections, Intralesional</subject><subject>Leishmaniasis, Cutaneous - drug therapy</subject><subject>Leshmaniasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Remission Induction</subject><subject>Treatment Outcome</subject><subject>Tropical medicine</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMGOmzAQhlHVaptu-wiVUFX1BrUxduw9VGIJm7glUAXQqifLGCORks0WJ2r27WsEyr2-WKP55vf4c5xPEPjQnq97HyKCvRCRwIeMEf9UA0QI8y-vnMXUIih47SwAgNBjALO3zjtj9rZEAQxvnBtKcQgJWTi_4qqMsiSvCjdNeLHZRhmPCl7cuUW8SVZVmhTuQ75zeVbuIlvwPItSt9wlUblNstJ95OXGLfIVr7ZuUfL7fJ1WsWXK5L3zppW90R_m-9apHpIy3nhpvuZxlHrK7h96GEClSK1lQyXRimAFNVW4Zi1aKkZxAyhALaQa61qGDWVNyFqsGyRD2oBAoVvny5T7PBz_nLU5iUNnlO57-aSPZyOW1P6UEmDBuwlUw9GYQbfieegOcngREIjRq9iLUZ4YvYrRq5i9iosd_ji_cq4PurmOziJt__Pcl0bJvh3kk-rMFUOQQghG7NuE_e16_fIfCwj-fYVZaAO8KaAzJ325BsjhtyBLtMTiMVsLGITk5w-4Exj9Ay5bnKw</recordid><startdate>199608</startdate><enddate>199608</enddate><creator>TALLAB, TALAL M.</creator><creator>BAHAMDAM, KHALID A.</creator><creator>MIRDAD, SOLEMAN</creator><creator>JOHARGI, HANAN</creator><creator>MOURAD, MOHAMED MAZE</creator><creator>IBRAHIM, KARAM</creator><creator>EL SHERBINI, ABDUL HAMEED</creator><creator>KARKASHAN, EMAN</creator><creator>KHARE, ASHOK KUMAR</creator><creator>JAMAL, AWATIF</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199608</creationdate><title>CUTANEOUS LEISHMANIASIS: SCHEDULES FOR INTRALESIONAL TREATMENT WITH SODIUM STIBOGLUCONATE</title><author>TALLAB, TALAL M. ; BAHAMDAM, KHALID A. ; MIRDAD, SOLEMAN ; JOHARGI, HANAN ; MOURAD, MOHAMED MAZE ; IBRAHIM, KARAM ; EL SHERBINI, ABDUL HAMEED ; KARKASHAN, EMAN ; KHARE, ASHOK KUMAR ; JAMAL, AWATIF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4364-501cc6bead8a6ec65c1e8c5b9f37c985d0803f18e5eba4d89d49f5ed3a48d02c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antimony Sodium Gluconate - administration & dosage</topic><topic>Antiprotozoal Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Injections, Intradermal</topic><topic>Injections, Intralesional</topic><topic>Leishmaniasis, Cutaneous - drug therapy</topic><topic>Leshmaniasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>Remission Induction</topic><topic>Treatment Outcome</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TALLAB, TALAL M.</creatorcontrib><creatorcontrib>BAHAMDAM, KHALID A.</creatorcontrib><creatorcontrib>MIRDAD, SOLEMAN</creatorcontrib><creatorcontrib>JOHARGI, HANAN</creatorcontrib><creatorcontrib>MOURAD, MOHAMED MAZE</creatorcontrib><creatorcontrib>IBRAHIM, KARAM</creatorcontrib><creatorcontrib>EL SHERBINI, ABDUL HAMEED</creatorcontrib><creatorcontrib>KARKASHAN, EMAN</creatorcontrib><creatorcontrib>KHARE, ASHOK KUMAR</creatorcontrib><creatorcontrib>JAMAL, AWATIF</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TALLAB, TALAL M.</au><au>BAHAMDAM, KHALID A.</au><au>MIRDAD, SOLEMAN</au><au>JOHARGI, HANAN</au><au>MOURAD, MOHAMED MAZE</au><au>IBRAHIM, KARAM</au><au>EL SHERBINI, ABDUL HAMEED</au><au>KARKASHAN, EMAN</au><au>KHARE, ASHOK KUMAR</au><au>JAMAL, AWATIF</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CUTANEOUS LEISHMANIASIS: SCHEDULES FOR INTRALESIONAL TREATMENT WITH SODIUM STIBOGLUCONATE</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>1996-08</date><risdate>1996</risdate><volume>35</volume><issue>8</issue><spage>594</spage><epage>597</epage><pages>594-597</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>Background. Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated.
Methods. Ninety‐six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule.
Results. The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate‐day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%.
Conclusions. Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8854166</pmid><doi>10.1111/j.1365-4362.1996.tb03669.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0011-9059 |
| ispartof | International journal of dermatology, 1996-08, Vol.35 (8), p.594-597 |
| issn | 0011-9059 1365-4632 |
| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | Adolescent Adult Antimony Sodium Gluconate - administration & dosage Antiprotozoal Agents - administration & dosage Biological and medical sciences Child Child, Preschool Drug Administration Schedule Female Follow-Up Studies Human protozoal diseases Humans Infectious diseases Injections, Intradermal Injections, Intralesional Leishmaniasis, Cutaneous - drug therapy Leshmaniasis Male Medical sciences Middle Aged Parasitic diseases Protozoal diseases Remission Induction Treatment Outcome Tropical medicine |
| title | CUTANEOUS LEISHMANIASIS: SCHEDULES FOR INTRALESIONAL TREATMENT WITH SODIUM STIBOGLUCONATE |
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