Immunohistochemical Studies on the Distribution of Endogenous Digitalis-like Substance (EDLS)-Containing Neurons in the Rat Hypothalamus, with Special Consideration on the Possibility of Their Coexistence with Posterior Lobe Hormones
The distribution of the perikarya of endogenous digitalis-like substance (EDLS)-containing neurons in the rat hypothalamus was studied by immunohistochemistry using digoxin and digitoxin antiserum. In addition, the possible coexistence of EDLS and posterior lobe hormones was examined using an immuno...
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| Veröffentlicht in: | Archives of Histology and Cytology 1988, Vol.51(1), pp.35-42 |
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| container_title | Archives of Histology and Cytology |
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| creator | IHARA, Norihiko YURI, Kazunari YAMADA, Hisao SANO, Yutaka |
| description | The distribution of the perikarya of endogenous digitalis-like substance (EDLS)-containing neurons in the rat hypothalamus was studied by immunohistochemistry using digoxin and digitoxin antiserum. In addition, the possible coexistence of EDLS and posterior lobe hormones was examined using an immunohistochemical double-staining technique. Digoxin-like immunoreactive neurons were demonstrated in the paraventricular and supraoptic nuclei and other hypothalamic areas. However, digitoxin-like immunoreactive neurons were not detected in the hypothalamus. A portion of the digoxin-like immunoreactive neurons showed immunoreactivity for vasopressin or oxytocin. From these results, it is suggested that these digoxin-like immunoreactive neurons correspond to “EDLS-producing neurons, ” and that EDLS seems to act not only as a natriuretic substance but also as a neurohormone or neurotransmitter. |
| doi_str_mv | 10.1679/aohc.51.35 |
| format | Article |
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In addition, the possible coexistence of EDLS and posterior lobe hormones was examined using an immunohistochemical double-staining technique. Digoxin-like immunoreactive neurons were demonstrated in the paraventricular and supraoptic nuclei and other hypothalamic areas. However, digitoxin-like immunoreactive neurons were not detected in the hypothalamus. A portion of the digoxin-like immunoreactive neurons showed immunoreactivity for vasopressin or oxytocin. From these results, it is suggested that these digoxin-like immunoreactive neurons correspond to “EDLS-producing neurons, ” and that EDLS seems to act not only as a natriuretic substance but also as a neurohormone or neurotransmitter.</description><identifier>ISSN: 0914-9465</identifier><identifier>EISSN: 1349-1717</identifier><identifier>DOI: 10.1679/aohc.51.35</identifier><identifier>PMID: 2458124</identifier><language>eng</language><publisher>Japan: International Society of Histology and Cytology</publisher><subject>Animals ; Blood Proteins - analysis ; Cardenolides ; Digoxin ; Hypothalamus - analysis ; Immune Sera ; Immunohistochemistry - methods ; Male ; Neurons - analysis ; Pituitary Hormones, Posterior - analysis ; Rats ; Rats, Inbred Strains ; Saponins ; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors ; Staining and Labeling</subject><ispartof>Archives of Histology and Cytology, 1988, Vol.51(1), pp.35-42</ispartof><rights>International Society of Histology and Cytology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-28530b61c110d9a0b69506a4b3e761984962b04a0de5773e5af04bd15873f1333</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2458124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IHARA, Norihiko</creatorcontrib><creatorcontrib>YURI, Kazunari</creatorcontrib><creatorcontrib>YAMADA, Hisao</creatorcontrib><creatorcontrib>SANO, Yutaka</creatorcontrib><title>Immunohistochemical Studies on the Distribution of Endogenous Digitalis-like Substance (EDLS)-Containing Neurons in the Rat Hypothalamus, with Special Consideration on the Possibility of Their Coexistence with Posterior Lobe Hormones</title><title>Archives of Histology and Cytology</title><addtitle>Arch. Histol. Cytol.</addtitle><description>The distribution of the perikarya of endogenous digitalis-like substance (EDLS)-containing neurons in the rat hypothalamus was studied by immunohistochemistry using digoxin and digitoxin antiserum. In addition, the possible coexistence of EDLS and posterior lobe hormones was examined using an immunohistochemical double-staining technique. Digoxin-like immunoreactive neurons were demonstrated in the paraventricular and supraoptic nuclei and other hypothalamic areas. However, digitoxin-like immunoreactive neurons were not detected in the hypothalamus. A portion of the digoxin-like immunoreactive neurons showed immunoreactivity for vasopressin or oxytocin. From these results, it is suggested that these digoxin-like immunoreactive neurons correspond to “EDLS-producing neurons, ” and that EDLS seems to act not only as a natriuretic substance but also as a neurohormone or neurotransmitter.</description><subject>Animals</subject><subject>Blood Proteins - analysis</subject><subject>Cardenolides</subject><subject>Digoxin</subject><subject>Hypothalamus - analysis</subject><subject>Immune Sera</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>Neurons - analysis</subject><subject>Pituitary Hormones, Posterior - analysis</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Saponins</subject><subject>Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</subject><subject>Staining and Labeling</subject><issn>0914-9465</issn><issn>1349-1717</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UU2P0zAQjRBoKQsX7kg-IUCk2LGdjyPqFrpSBYgu58hxps0sid21HUF_Mv8CZ1P14rH83rx5npckrxldsryoPinb6aVkSy6fJAvGRZWyghVPkwWtmEgrkcvnyQvv7ynlGc_YVXKVCVmyTCySf7fDMBrboQ9WdzCgVj3ZhbFF8MQaEjogNxF02IwB44Pdk7Vp7QGMHX2EDhhUjz7t8TeQ3dj4oIwG8m59s929T1fWBIUGzYF8g9FZ4wnOoj9VIJvT0YZO9WoY_UfyB0NHdkfQGC3ERo8tODUPnXt-WO-xwR7DafJx1wG6yIS_0SBMUx8lIiuAQ-vI1jZANtYN1oB_mTzbq97Dq3O9Tn59Wd-tNun2-9fb1edtqoUQIc1KyWmTM80YbSsVr5WkuRINhyJnVSmqPGuoULQFWRQcpNpT0bRMlgXfM875dfJ21j06-zCCD_WAXkPfKwNxZXVRCiaLsozEDzNRu_gvB_v66HBQ7lQzWk-51lOutWQ1l5H85qw6NgO0F-o5yIivZvw-BnCAC65cQN3Do1R0X05ybD64vKC6U64Gw_8DObK7Vg</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>IHARA, Norihiko</creator><creator>YURI, Kazunari</creator><creator>YAMADA, Hisao</creator><creator>SANO, Yutaka</creator><general>International Society of Histology and Cytology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880101</creationdate><title>Immunohistochemical Studies on the Distribution of Endogenous Digitalis-like Substance (EDLS)-Containing Neurons in the Rat Hypothalamus, with Special Consideration on the Possibility of Their Coexistence with Posterior Lobe Hormones</title><author>IHARA, Norihiko ; YURI, Kazunari ; YAMADA, Hisao ; SANO, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-28530b61c110d9a0b69506a4b3e761984962b04a0de5773e5af04bd15873f1333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Blood Proteins - analysis</topic><topic>Cardenolides</topic><topic>Digoxin</topic><topic>Hypothalamus - analysis</topic><topic>Immune Sera</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>Neurons - analysis</topic><topic>Pituitary Hormones, Posterior - analysis</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Saponins</topic><topic>Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IHARA, Norihiko</creatorcontrib><creatorcontrib>YURI, Kazunari</creatorcontrib><creatorcontrib>YAMADA, Hisao</creatorcontrib><creatorcontrib>SANO, Yutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Histology and Cytology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IHARA, Norihiko</au><au>YURI, Kazunari</au><au>YAMADA, Hisao</au><au>SANO, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical Studies on the Distribution of Endogenous Digitalis-like Substance (EDLS)-Containing Neurons in the Rat Hypothalamus, with Special Consideration on the Possibility of Their Coexistence with Posterior Lobe Hormones</atitle><jtitle>Archives of Histology and Cytology</jtitle><addtitle>Arch. Histol. Cytol.</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>51</volume><issue>1</issue><spage>35</spage><epage>42</epage><pages>35-42</pages><issn>0914-9465</issn><eissn>1349-1717</eissn><abstract>The distribution of the perikarya of endogenous digitalis-like substance (EDLS)-containing neurons in the rat hypothalamus was studied by immunohistochemistry using digoxin and digitoxin antiserum. In addition, the possible coexistence of EDLS and posterior lobe hormones was examined using an immunohistochemical double-staining technique. Digoxin-like immunoreactive neurons were demonstrated in the paraventricular and supraoptic nuclei and other hypothalamic areas. However, digitoxin-like immunoreactive neurons were not detected in the hypothalamus. A portion of the digoxin-like immunoreactive neurons showed immunoreactivity for vasopressin or oxytocin. From these results, it is suggested that these digoxin-like immunoreactive neurons correspond to “EDLS-producing neurons, ” and that EDLS seems to act not only as a natriuretic substance but also as a neurohormone or neurotransmitter.</abstract><cop>Japan</cop><pub>International Society of Histology and Cytology</pub><pmid>2458124</pmid><doi>10.1679/aohc.51.35</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-9465 |
| ispartof | Archives of Histology and Cytology, 1988, Vol.51(1), pp.35-42 |
| issn | 0914-9465 1349-1717 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Blood Proteins - analysis Cardenolides Digoxin Hypothalamus - analysis Immune Sera Immunohistochemistry - methods Male Neurons - analysis Pituitary Hormones, Posterior - analysis Rats Rats, Inbred Strains Saponins Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Staining and Labeling |
| title | Immunohistochemical Studies on the Distribution of Endogenous Digitalis-like Substance (EDLS)-Containing Neurons in the Rat Hypothalamus, with Special Consideration on the Possibility of Their Coexistence with Posterior Lobe Hormones |
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