Nerve growth factor enhances nerve regeneration through fibronectin grafts

Soluble fibronectin and nerve growth factor (NGF) promote axonal regeneration when placed in silicone tubes. We investigated the ability of orientated fibronectin mats to bind and release bioactive NGF and the possibility of augmenting axonal regeneration following axotomy by using fibronectin condu...

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Veröffentlicht in:	Journal of hand surgery, British volume British volume, 1996-08, Vol.21 (4), p.514-522
Hauptverfasser:	Whitworth, I.H., Brown, R.A., Doré, C.J., Anand, P., Green, C.J., Terenghi, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - pathology Biological and medical sciences Calcitonin Gene-Related Peptide - analysis Chick Embryo Cranial nerves. Peripheral nerves. Autonomic nervous system Culture Techniques Drug Implants Fibronectins Ganglia, Spinal - drug effects Ganglia, Spinal - pathology Immunoenzyme Techniques Medical sciences Nerve Fibers, Myelinated - drug effects Nerve Fibers, Myelinated - pathology Nerve Growth Factors - pharmacology Nerve Regeneration - drug effects Neurosurgery Rats Rats, Inbred Lew Schwann Cells - drug effects Schwann Cells - pathology Sciatic Nerve - drug effects Sciatic Nerve - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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