Neonatal cocaine exposure and activity rhythms in rats
This study looked at the effects of neonatal cocaine exposure on activity rhythms over a 48-h period in rats. Subjects were artificially-reared from postnatal days (PN) 4–10 via intragastric cannulas. The four treatment groups included two cocaine doses (20 and 40 mg/kg per day), an artificially-rea...
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| Veröffentlicht in: | Behavioural brain research 1996, Vol.74 (1), p.167-174 |
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| creator | Barron, Susan Hansen-Trench, Lynne S. Kaiser, Daren H. |
| description | This study looked at the effects of neonatal cocaine exposure on activity rhythms over a 48-h period in rats. Subjects were artificially-reared from postnatal days (PN) 4–10 via intragastric cannulas. The four treatment groups included two cocaine doses (20 and 40 mg/kg per day), an artificially-reared control and a normally reared suckled control. Subjects were tested at PN 38–40 in an automated running wheel. Neonatal cocaine exposure did not alter activity rhythms over the 48-h test period. However, there was a gender-specific effect of neonatal cocaine exposure on response to the novel test chamber and to the experimenter. The 20 mg/kg cocaine-exposed females showed increased running wheel activity relative to all other groups after placement in the running wheel. During the second 24-h period, cocaine-exposed females from both cocaine groups showed increased activity relative to controls following the entry of an experimenter to the test room. These findings suggest that female rats exposed to cocaine neonatally show an increased response to novel environments and stimuli. |
| doi_str_mv | 10.1016/0166-4328(95)00149-2 |
| format | Article |
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Subjects were artificially-reared from postnatal days (PN) 4–10 via intragastric cannulas. The four treatment groups included two cocaine doses (20 and 40 mg/kg per day), an artificially-reared control and a normally reared suckled control. Subjects were tested at PN 38–40 in an automated running wheel. Neonatal cocaine exposure did not alter activity rhythms over the 48-h test period. However, there was a gender-specific effect of neonatal cocaine exposure on response to the novel test chamber and to the experimenter. The 20 mg/kg cocaine-exposed females showed increased running wheel activity relative to all other groups after placement in the running wheel. During the second 24-h period, cocaine-exposed females from both cocaine groups showed increased activity relative to controls following the entry of an experimenter to the test room. These findings suggest that female rats exposed to cocaine neonatally show an increased response to novel environments and stimuli.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/0166-4328(95)00149-2</identifier><identifier>PMID: 8851926</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Animals, Newborn - physiology ; Behavioral psychophysiology ; Behavioral tetratology ; Biological and medical sciences ; Body Weight - drug effects ; Circadian Rhythm - drug effects ; Cocaine - administration & dosage ; Cocaine - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Intubation, Gastrointestinal ; Locomotor activity ; Male ; Motor Activity - drug effects ; Narcotics - administration & dosage ; Narcotics - pharmacology ; Neonatal cocaine exposure ; Neurotransmission and behavior ; Psychology. 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Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Sex Characteristics</subject><ispartof>Behavioural brain research, 1996, Vol.74 (1), p.167-174</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-3bf7ecec7311408fd77fc42119189a3332ff9cbc08651e7cf5b9d17052a22bea3</citedby><cites>FETCH-LOGICAL-c417t-3bf7ecec7311408fd77fc42119189a3332ff9cbc08651e7cf5b9d17052a22bea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0166-4328(95)00149-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2986929$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8851926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barron, Susan</creatorcontrib><creatorcontrib>Hansen-Trench, Lynne S.</creatorcontrib><creatorcontrib>Kaiser, Daren H.</creatorcontrib><title>Neonatal cocaine exposure and activity rhythms in rats</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>This study looked at the effects of neonatal cocaine exposure on activity rhythms over a 48-h period in rats. Subjects were artificially-reared from postnatal days (PN) 4–10 via intragastric cannulas. The four treatment groups included two cocaine doses (20 and 40 mg/kg per day), an artificially-reared control and a normally reared suckled control. Subjects were tested at PN 38–40 in an automated running wheel. Neonatal cocaine exposure did not alter activity rhythms over the 48-h test period. However, there was a gender-specific effect of neonatal cocaine exposure on response to the novel test chamber and to the experimenter. The 20 mg/kg cocaine-exposed females showed increased running wheel activity relative to all other groups after placement in the running wheel. During the second 24-h period, cocaine-exposed females from both cocaine groups showed increased activity relative to controls following the entry of an experimenter to the test room. These findings suggest that female rats exposed to cocaine neonatally show an increased response to novel environments and stimuli.</description><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Behavioral tetratology</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Circadian Rhythm - drug effects</subject><subject>Cocaine - administration & dosage</subject><subject>Cocaine - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Intubation, Gastrointestinal</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Narcotics - administration & dosage</subject><subject>Narcotics - pharmacology</subject><subject>Neonatal cocaine exposure</subject><subject>Neurotransmission and behavior</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sex Characteristics</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpSTdp_0EKPpSQHpxq9GFJl0AIbVMIySU5C3k8Igpeeyt5Q_bf15td9tgehjnM884MD2OnwC-AQ_N9rqZWUthzp79xDsrV4h1bgDWiNlq592xxQD6y41KeOeeKazhiR9ZqcKJZsOaOxiFMoa9wxJAGquh1NZZ1pioMXRVwSi9p2lT5aTM9LUuVhiqHqXxiH2LoC33e9xP2-PPHw_VNfXv_6_f11W2NCsxUyzYaQkIjARS3sTMmohIADqwLUkoRo8MWuW00kMGoW9eB4VoEIVoK8oSd7fau8vhnTWXyy1SQ-j4MNK6LN1aBFBr-C0LD57NKzqDagZjHUjJFv8ppGfLGA_dbr34rzW-leaf9m1cv5tiX_f51u6TuENqLnOdf9_NQMPQxhwFTOWDC2cYJN2OXO4xmaS-Jsi-YaEDqUiacfDemf__xFwQSkpo</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Barron, Susan</creator><creator>Hansen-Trench, Lynne S.</creator><creator>Kaiser, Daren H.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Neonatal cocaine exposure and activity rhythms in rats</title><author>Barron, Susan ; Hansen-Trench, Lynne S. ; Kaiser, Daren H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3bf7ecec7311408fd77fc42119189a3332ff9cbc08651e7cf5b9d17052a22bea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Behavioral tetratology</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Circadian Rhythm - drug effects</topic><topic>Cocaine - administration & dosage</topic><topic>Cocaine - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Intubation, Gastrointestinal</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Narcotics - administration & dosage</topic><topic>Narcotics - pharmacology</topic><topic>Neonatal cocaine exposure</topic><topic>Neurotransmission and behavior</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barron, Susan</creatorcontrib><creatorcontrib>Hansen-Trench, Lynne S.</creatorcontrib><creatorcontrib>Kaiser, Daren H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barron, Susan</au><au>Hansen-Trench, Lynne S.</au><au>Kaiser, Daren H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal cocaine exposure and activity rhythms in rats</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>1996</date><risdate>1996</risdate><volume>74</volume><issue>1</issue><spage>167</spage><epage>174</epage><pages>167-174</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>This study looked at the effects of neonatal cocaine exposure on activity rhythms over a 48-h period in rats. Subjects were artificially-reared from postnatal days (PN) 4–10 via intragastric cannulas. The four treatment groups included two cocaine doses (20 and 40 mg/kg per day), an artificially-reared control and a normally reared suckled control. Subjects were tested at PN 38–40 in an automated running wheel. Neonatal cocaine exposure did not alter activity rhythms over the 48-h test period. However, there was a gender-specific effect of neonatal cocaine exposure on response to the novel test chamber and to the experimenter. The 20 mg/kg cocaine-exposed females showed increased running wheel activity relative to all other groups after placement in the running wheel. During the second 24-h period, cocaine-exposed females from both cocaine groups showed increased activity relative to controls following the entry of an experimenter to the test room. These findings suggest that female rats exposed to cocaine neonatally show an increased response to novel environments and stimuli.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>8851926</pmid><doi>10.1016/0166-4328(95)00149-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Behavioural brain research, 1996, Vol.74 (1), p.167-174 |
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| language | eng |
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| subjects | Animals Animals, Newborn - physiology Behavioral psychophysiology Behavioral tetratology Biological and medical sciences Body Weight - drug effects Circadian Rhythm - drug effects Cocaine - administration & dosage Cocaine - pharmacology Female Fundamental and applied biological sciences. Psychology Intubation, Gastrointestinal Locomotor activity Male Motor Activity - drug effects Narcotics - administration & dosage Narcotics - pharmacology Neonatal cocaine exposure Neurotransmission and behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Sex Characteristics |
| title | Neonatal cocaine exposure and activity rhythms in rats |
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