Incidence of scoliosis in β-thalassemia and follow-up evaluation
One hundred fifteen of 120 patients with beta-thalassemia followed in the thalassemia unit were studied for the presence of scoliosis. Forty-nine of these patients were reevaluated 1 year later. To determine the frequency and the course of scoliosis in beta-thalassemia and to compare the findings wi...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 1996-08, Vol.21 (15), p.1798-1801 |
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| creator | KOROVESSIS, P PAPANASTASIOU, D TINIAKOU, M BERATIS, N. G |
| description | One hundred fifteen of 120 patients with beta-thalassemia followed in the thalassemia unit were studied for the presence of scoliosis. Forty-nine of these patients were reevaluated 1 year later.
To determine the frequency and the course of scoliosis in beta-thalassemia and to compare the findings with those of patients with idiopathic scoliosis.
There is only one report indicating increased frequency of scoliosis in a limited number of patients with thalassemia. In this study, the authors assessed the frequency of scoliosis in a large sample of patients and followed the evolution of this spinal deformity.
Patients with beta-thalassemia aged 3-35 years were examined clinically and radiologically for scoliosis. Forty-nine of them were reexamined 1 year later for determination of the evolution of scoliosis.
Lateral curves of at least 5 degrees Cobb were found in 77 patients (67%), with a male-to-female ratio of 0.9. Scoliosis of at least 10 degrees was found in 21.7% of the male and 20% of the female patients with thalassemia. The ratio was 1.18 for curves of at least 10 degrees and 0.77 for curves of a smaller magnitude. The most common curve pattern was the left lumbar (35.1%), followed by the double-curve pattern (16.9%). Forty-nine randomly selected patients (42.6%) of the 115 included in the study were reexamined 1 year later. Seven male and 7 female patients (total, 28.6%) showed a progression of at least 5 degrees. Six patients (12.2%) experienced spontaneous improvement of less than 6 degrees. The pattern and the evolution of scoliosis observed in patients with beta-thalassemia differ from those found in Greek children with idiopathic scoliosis.
The findings of this study show that the incidence, evolution, and etiology of scoliosis in beta-thalassemia differ from those of idiopathic scoliosis, indicating that the spinal deformities in patients with beta-thalassemia represents a distinct type of scoliosis. Longer follow-up is needed to investigate the natural history of this type of scoliosis. |
| doi_str_mv | 10.1097/00007632-199608010-00015 |
| format | Article |
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To determine the frequency and the course of scoliosis in beta-thalassemia and to compare the findings with those of patients with idiopathic scoliosis.
There is only one report indicating increased frequency of scoliosis in a limited number of patients with thalassemia. In this study, the authors assessed the frequency of scoliosis in a large sample of patients and followed the evolution of this spinal deformity.
Patients with beta-thalassemia aged 3-35 years were examined clinically and radiologically for scoliosis. Forty-nine of them were reexamined 1 year later for determination of the evolution of scoliosis.
Lateral curves of at least 5 degrees Cobb were found in 77 patients (67%), with a male-to-female ratio of 0.9. Scoliosis of at least 10 degrees was found in 21.7% of the male and 20% of the female patients with thalassemia. The ratio was 1.18 for curves of at least 10 degrees and 0.77 for curves of a smaller magnitude. The most common curve pattern was the left lumbar (35.1%), followed by the double-curve pattern (16.9%). Forty-nine randomly selected patients (42.6%) of the 115 included in the study were reexamined 1 year later. Seven male and 7 female patients (total, 28.6%) showed a progression of at least 5 degrees. Six patients (12.2%) experienced spontaneous improvement of less than 6 degrees. The pattern and the evolution of scoliosis observed in patients with beta-thalassemia differ from those found in Greek children with idiopathic scoliosis.
The findings of this study show that the incidence, evolution, and etiology of scoliosis in beta-thalassemia differ from those of idiopathic scoliosis, indicating that the spinal deformities in patients with beta-thalassemia represents a distinct type of scoliosis. Longer follow-up is needed to investigate the natural history of this type of scoliosis.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/00007632-199608010-00015</identifier><identifier>PMID: 8855465</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Adolescent ; Adult ; Age Distribution ; Analysis of Variance ; beta-Thalassemia - complications ; beta-Thalassemia - diagnostic imaging ; Biological and medical sciences ; Child ; Child, Preschool ; Disease Progression ; Diseases of the osteoarticular system ; Diseases of the spine ; Female ; Follow-Up Studies ; Greece - epidemiology ; Humans ; Incidence ; Male ; Medical sciences ; Radiography ; Random Allocation ; Scoliosis - diagnostic imaging ; Scoliosis - epidemiology ; Scoliosis - etiology ; Sex Distribution</subject><ispartof>Spine (Philadelphia, Pa. 1976), 1996-08, Vol.21 (15), p.1798-1801</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-836e3e8aa1991ca4ebdf59fe30ba6ff253862fec6765933a1090e89966ed66c33</citedby><cites>FETCH-LOGICAL-c368t-836e3e8aa1991ca4ebdf59fe30ba6ff253862fec6765933a1090e89966ed66c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3178047$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8855465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOROVESSIS, P</creatorcontrib><creatorcontrib>PAPANASTASIOU, D</creatorcontrib><creatorcontrib>TINIAKOU, M</creatorcontrib><creatorcontrib>BERATIS, N. G</creatorcontrib><title>Incidence of scoliosis in β-thalassemia and follow-up evaluation</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>One hundred fifteen of 120 patients with beta-thalassemia followed in the thalassemia unit were studied for the presence of scoliosis. Forty-nine of these patients were reevaluated 1 year later.
To determine the frequency and the course of scoliosis in beta-thalassemia and to compare the findings with those of patients with idiopathic scoliosis.
There is only one report indicating increased frequency of scoliosis in a limited number of patients with thalassemia. In this study, the authors assessed the frequency of scoliosis in a large sample of patients and followed the evolution of this spinal deformity.
Patients with beta-thalassemia aged 3-35 years were examined clinically and radiologically for scoliosis. Forty-nine of them were reexamined 1 year later for determination of the evolution of scoliosis.
Lateral curves of at least 5 degrees Cobb were found in 77 patients (67%), with a male-to-female ratio of 0.9. Scoliosis of at least 10 degrees was found in 21.7% of the male and 20% of the female patients with thalassemia. The ratio was 1.18 for curves of at least 10 degrees and 0.77 for curves of a smaller magnitude. The most common curve pattern was the left lumbar (35.1%), followed by the double-curve pattern (16.9%). Forty-nine randomly selected patients (42.6%) of the 115 included in the study were reexamined 1 year later. Seven male and 7 female patients (total, 28.6%) showed a progression of at least 5 degrees. Six patients (12.2%) experienced spontaneous improvement of less than 6 degrees. The pattern and the evolution of scoliosis observed in patients with beta-thalassemia differ from those found in Greek children with idiopathic scoliosis.
The findings of this study show that the incidence, evolution, and etiology of scoliosis in beta-thalassemia differ from those of idiopathic scoliosis, indicating that the spinal deformities in patients with beta-thalassemia represents a distinct type of scoliosis. Longer follow-up is needed to investigate the natural history of this type of scoliosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Analysis of Variance</subject><subject>beta-Thalassemia - complications</subject><subject>beta-Thalassemia - diagnostic imaging</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease Progression</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Greece - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Radiography</subject><subject>Random Allocation</subject><subject>Scoliosis - diagnostic imaging</subject><subject>Scoliosis - epidemiology</subject><subject>Scoliosis - etiology</subject><subject>Sex Distribution</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtOwzAQhi0EKqVwBKQsEDuDHceOs6wqXlIlNrCOps5YGDlxiRMQ1-IgnAlDQ2cz0vz_vD5CMs6uOKvKa5aiVCKnvKoU04wzmipcHpA5l7mmnMvqkMyZUDnNC6GOyUmMr8miBK9mZKa1lIWSc7J86IxrsDOYBZtFE7wL0cXMddn3Fx1ewEOM2DrIoGsyG7wPH3TcZvgOfoTBhe6UHFnwEc-mvCDPtzdPq3u6frx7WC3X1AilB6qFQoEaIF3MDRS4aaysLAq2AWVtLoVWuUWjSiUrISC9yVCn7xQ2ShkhFuRyN3fbh7cR41C3Lhr0HjoMY6xLXfBEQCWj3hlNH2Ls0dbb3rXQf9ac1b_06n969Z5e_UcvtZ5PO8ZNi82-ccKV9ItJh2jA2x4Svbi3CV5qVpTiB-WYd2Y</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>KOROVESSIS, P</creator><creator>PAPANASTASIOU, D</creator><creator>TINIAKOU, M</creator><creator>BERATIS, N. G</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Incidence of scoliosis in β-thalassemia and follow-up evaluation</title><author>KOROVESSIS, P ; PAPANASTASIOU, D ; TINIAKOU, M ; BERATIS, N. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-836e3e8aa1991ca4ebdf59fe30ba6ff253862fec6765933a1090e89966ed66c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Analysis of Variance</topic><topic>beta-Thalassemia - complications</topic><topic>beta-Thalassemia - diagnostic imaging</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease Progression</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Greece - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Radiography</topic><topic>Random Allocation</topic><topic>Scoliosis - diagnostic imaging</topic><topic>Scoliosis - epidemiology</topic><topic>Scoliosis - etiology</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOROVESSIS, P</creatorcontrib><creatorcontrib>PAPANASTASIOU, D</creatorcontrib><creatorcontrib>TINIAKOU, M</creatorcontrib><creatorcontrib>BERATIS, N. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOROVESSIS, P</au><au>PAPANASTASIOU, D</au><au>TINIAKOU, M</au><au>BERATIS, N. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of scoliosis in β-thalassemia and follow-up evaluation</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>21</volume><issue>15</issue><spage>1798</spage><epage>1801</epage><pages>1798-1801</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>One hundred fifteen of 120 patients with beta-thalassemia followed in the thalassemia unit were studied for the presence of scoliosis. Forty-nine of these patients were reevaluated 1 year later.
To determine the frequency and the course of scoliosis in beta-thalassemia and to compare the findings with those of patients with idiopathic scoliosis.
There is only one report indicating increased frequency of scoliosis in a limited number of patients with thalassemia. In this study, the authors assessed the frequency of scoliosis in a large sample of patients and followed the evolution of this spinal deformity.
Patients with beta-thalassemia aged 3-35 years were examined clinically and radiologically for scoliosis. Forty-nine of them were reexamined 1 year later for determination of the evolution of scoliosis.
Lateral curves of at least 5 degrees Cobb were found in 77 patients (67%), with a male-to-female ratio of 0.9. Scoliosis of at least 10 degrees was found in 21.7% of the male and 20% of the female patients with thalassemia. The ratio was 1.18 for curves of at least 10 degrees and 0.77 for curves of a smaller magnitude. The most common curve pattern was the left lumbar (35.1%), followed by the double-curve pattern (16.9%). Forty-nine randomly selected patients (42.6%) of the 115 included in the study were reexamined 1 year later. Seven male and 7 female patients (total, 28.6%) showed a progression of at least 5 degrees. Six patients (12.2%) experienced spontaneous improvement of less than 6 degrees. The pattern and the evolution of scoliosis observed in patients with beta-thalassemia differ from those found in Greek children with idiopathic scoliosis.
The findings of this study show that the incidence, evolution, and etiology of scoliosis in beta-thalassemia differ from those of idiopathic scoliosis, indicating that the spinal deformities in patients with beta-thalassemia represents a distinct type of scoliosis. Longer follow-up is needed to investigate the natural history of this type of scoliosis.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>8855465</pmid><doi>10.1097/00007632-199608010-00015</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0362-2436 |
| ispartof | Spine (Philadelphia, Pa. 1976), 1996-08, Vol.21 (15), p.1798-1801 |
| issn | 0362-2436 1528-1159 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Age Distribution Analysis of Variance beta-Thalassemia - complications beta-Thalassemia - diagnostic imaging Biological and medical sciences Child Child, Preschool Disease Progression Diseases of the osteoarticular system Diseases of the spine Female Follow-Up Studies Greece - epidemiology Humans Incidence Male Medical sciences Radiography Random Allocation Scoliosis - diagnostic imaging Scoliosis - epidemiology Scoliosis - etiology Sex Distribution |
| title | Incidence of scoliosis in β-thalassemia and follow-up evaluation |
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