A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines

Local delivery of serotonin (5-HT) produces a rapid edematous response in soft tissues via increased fluid extravasation which is prevented by 5-HT2 antagonists such as ketanserin or mianserin. Here we report the effects of a new class of aminoguanidine 5-HT2 antagonists, with relative selectivity f...

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Veröffentlicht in:	Life sciences (1973) 1996-09, Vol.59 (15), p.1259-1268
Hauptverfasser:	Bryant, H U, Nelson, D L, Button, D, Cole, H W, Baez, M B, Lucaites, V L, Wainscott, D B, Whitesitt, C, Reel, J, Simon, R, Koppel, G A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Transformed Cell Membrane - metabolism Cricetinae Edema - chemically induced Female Guanidines - chemistry Guanidines - metabolism Guanidines - pharmacology Humans Mesocricetus Molecular Structure Ovariectomy Rats Rats, Sprague-Dawley Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Serotonin - metabolism Serotonin Antagonists - pharmacology
Online-Zugang:	Volltext
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