An Autopsy Case of Histiocytic Medullary Reticulosis Presenting with Marked Hepatosplenomegaly for 13 Years before the Onset
A 32-year-old male was hospitalized with high fever, pancytopenia and hepatosplenomegaly. No atypical cells were found in the peripheral blood. Bone marrow aspiration resulted in dry taps. Superficial lymph node swelling was not observed. He had been treated twice for high fever, hepatosplenomegaly...
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| Veröffentlicht in: | Japanese Journal of Medicine 1988, Vol.27(2), pp.195-199 |
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| container_end_page | 199 |
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| container_issue | 2 |
| container_start_page | 195 |
| container_title | Japanese Journal of Medicine |
| container_volume | 27 |
| creator | NANNO, Tatsuo ADACHI, Yukihiko ENOMOTO, Masakazu NAGAMINE, Yasuroh SUWA, Masao SUZUKI, Tsuneyuki TAKAOKA, Aimei YAMAMOTO, Toshio |
| description | A 32-year-old male was hospitalized with high fever, pancytopenia and hepatosplenomegaly. No atypical cells were found in the peripheral blood. Bone marrow aspiration resulted in dry taps. Superficial lymph node swelling was not observed. He had been treated twice for high fever, hepatosplenomegaly and leukopenia that were very similar to the present illness, 13 and 3 years before the onset and hepatosplenomegaly had been noted by the patient for 13 years. The patient died after a rapid course of 20 days. Histiocytic medullary reticulosis (HMR) was diagnosed at the autopsy, which revealed atypical histiocytic infiltration showing erythrophagocytosis in the liver, spleen, left adrenal, and mesenterial and pulmonary hilar lymph nodes. This patient had shown the same clinical signs and hepatosplenomegaly 13 years before the onset of HMR, which suggest a possible latent stage and acute exacerbation of HMR. |
| doi_str_mv | 10.2169/internalmedicine1962.27.195 |
| format | Article |
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No atypical cells were found in the peripheral blood. Bone marrow aspiration resulted in dry taps. Superficial lymph node swelling was not observed. He had been treated twice for high fever, hepatosplenomegaly and leukopenia that were very similar to the present illness, 13 and 3 years before the onset and hepatosplenomegaly had been noted by the patient for 13 years. The patient died after a rapid course of 20 days. Histiocytic medullary reticulosis (HMR) was diagnosed at the autopsy, which revealed atypical histiocytic infiltration showing erythrophagocytosis in the liver, spleen, left adrenal, and mesenterial and pulmonary hilar lymph nodes. This patient had shown the same clinical signs and hepatosplenomegaly 13 years before the onset of HMR, which suggest a possible latent stage and acute exacerbation of HMR.</description><identifier>ISSN: 0021-5120</identifier><identifier>EISSN: 1881-123X</identifier><identifier>DOI: 10.2169/internalmedicine1962.27.195</identifier><identifier>PMID: 3418986</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Autopsy ; Hepatomegaly - complications ; Hepatomegaly - pathology ; Histiocytic Sarcoma - complications ; Histiocytic Sarcoma - diagnosis ; Histiocytic Sarcoma - pathology ; Hodgkin's disease ; Humans ; Male ; Malignant histiocytosis ; Splenomegaly - complications ; Splenomegaly - pathology</subject><ispartof>Japanese Journal of Medicine, 1988, Vol.27(2), pp.195-199</ispartof><rights>The Japanese Society of Internal Medicine</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3418986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NANNO, Tatsuo</creatorcontrib><creatorcontrib>ADACHI, Yukihiko</creatorcontrib><creatorcontrib>ENOMOTO, Masakazu</creatorcontrib><creatorcontrib>NAGAMINE, Yasuroh</creatorcontrib><creatorcontrib>SUWA, Masao</creatorcontrib><creatorcontrib>SUZUKI, Tsuneyuki</creatorcontrib><creatorcontrib>TAKAOKA, Aimei</creatorcontrib><creatorcontrib>YAMAMOTO, Toshio</creatorcontrib><title>An Autopsy Case of Histiocytic Medullary Reticulosis Presenting with Marked Hepatosplenomegaly for 13 Years before the Onset</title><title>Japanese Journal of Medicine</title><addtitle>Japanese Journal of Medicine</addtitle><description>A 32-year-old male was hospitalized with high fever, pancytopenia and hepatosplenomegaly. No atypical cells were found in the peripheral blood. Bone marrow aspiration resulted in dry taps. Superficial lymph node swelling was not observed. He had been treated twice for high fever, hepatosplenomegaly and leukopenia that were very similar to the present illness, 13 and 3 years before the onset and hepatosplenomegaly had been noted by the patient for 13 years. The patient died after a rapid course of 20 days. Histiocytic medullary reticulosis (HMR) was diagnosed at the autopsy, which revealed atypical histiocytic infiltration showing erythrophagocytosis in the liver, spleen, left adrenal, and mesenterial and pulmonary hilar lymph nodes. This patient had shown the same clinical signs and hepatosplenomegaly 13 years before the onset of HMR, which suggest a possible latent stage and acute exacerbation of HMR.</description><subject>Adult</subject><subject>Autopsy</subject><subject>Hepatomegaly - complications</subject><subject>Hepatomegaly - pathology</subject><subject>Histiocytic Sarcoma - complications</subject><subject>Histiocytic Sarcoma - diagnosis</subject><subject>Histiocytic Sarcoma - pathology</subject><subject>Hodgkin's disease</subject><subject>Humans</subject><subject>Male</subject><subject>Malignant histiocytosis</subject><subject>Splenomegaly - complications</subject><subject>Splenomegaly - pathology</subject><issn>0021-5120</issn><issn>1881-123X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kFtrGzEQhUVpSN20P6EgKPRtXV32ItEnY9K6kJAQEmifhFY7spWupa2kpRj646ti46f2ZYbhnJnDfAi9p2TJaCs_Op8hej3uYXDGeaCyZUvWLalsXqAFFYJWlPFvL9GCEEarhjLyCr1O6ZmQumWCXaJLXlMhRbtAv1cer-YcpnTAa50AB4s3LmUXzCE7g29hmMdRxwN-gDLPY0gu4fsICXx2fot_ubzDtzr-gAFvYNI5pGkEH_aw1eMB2xAx5fg76JhwD2UEnHeA73yC_AZdWD0meHvqV-jp8_XjelPd3H35ul7dVKZuSK5oy0EPPeeWWcv6nkjCa2GgJ7YbeM-47qU2jR24BDmQphlYJ21HGj0YITXjV-jD8e4Uw88ZUlZ7lwyUvzyEOalO1ERQJorx09FoYkgpglVTdPvyvaJE_WWv_sVesU4V9mX73Slm7ot-3j3BLvr9UX9OWW_hrOtYyI7w39unUiLOVrPTUYHnfwBJXKYO</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>NANNO, Tatsuo</creator><creator>ADACHI, Yukihiko</creator><creator>ENOMOTO, Masakazu</creator><creator>NAGAMINE, Yasuroh</creator><creator>SUWA, Masao</creator><creator>SUZUKI, Tsuneyuki</creator><creator>TAKAOKA, Aimei</creator><creator>YAMAMOTO, Toshio</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>An Autopsy Case of Histiocytic Medullary Reticulosis Presenting with Marked Hepatosplenomegaly for 13 Years before the Onset</title><author>NANNO, Tatsuo ; ADACHI, Yukihiko ; ENOMOTO, Masakazu ; NAGAMINE, Yasuroh ; SUWA, Masao ; SUZUKI, Tsuneyuki ; TAKAOKA, Aimei ; YAMAMOTO, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-163eadb33f2ff2bb090348ceb0f7d3b23ab9ac5fd39e9d055d279f705adc89a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Autopsy</topic><topic>Hepatomegaly - complications</topic><topic>Hepatomegaly - pathology</topic><topic>Histiocytic Sarcoma - complications</topic><topic>Histiocytic Sarcoma - diagnosis</topic><topic>Histiocytic Sarcoma - pathology</topic><topic>Hodgkin's disease</topic><topic>Humans</topic><topic>Male</topic><topic>Malignant histiocytosis</topic><topic>Splenomegaly - complications</topic><topic>Splenomegaly - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>NANNO, Tatsuo</creatorcontrib><creatorcontrib>ADACHI, Yukihiko</creatorcontrib><creatorcontrib>ENOMOTO, Masakazu</creatorcontrib><creatorcontrib>NAGAMINE, Yasuroh</creatorcontrib><creatorcontrib>SUWA, Masao</creatorcontrib><creatorcontrib>SUZUKI, Tsuneyuki</creatorcontrib><creatorcontrib>TAKAOKA, Aimei</creatorcontrib><creatorcontrib>YAMAMOTO, Toshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NANNO, Tatsuo</au><au>ADACHI, Yukihiko</au><au>ENOMOTO, Masakazu</au><au>NAGAMINE, Yasuroh</au><au>SUWA, Masao</au><au>SUZUKI, Tsuneyuki</au><au>TAKAOKA, Aimei</au><au>YAMAMOTO, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Autopsy Case of Histiocytic Medullary Reticulosis Presenting with Marked Hepatosplenomegaly for 13 Years before the Onset</atitle><jtitle>Japanese Journal of Medicine</jtitle><addtitle>Japanese Journal of Medicine</addtitle><date>1988</date><risdate>1988</risdate><volume>27</volume><issue>2</issue><spage>195</spage><epage>199</epage><pages>195-199</pages><issn>0021-5120</issn><eissn>1881-123X</eissn><abstract>A 32-year-old male was hospitalized with high fever, pancytopenia and hepatosplenomegaly. No atypical cells were found in the peripheral blood. Bone marrow aspiration resulted in dry taps. Superficial lymph node swelling was not observed. He had been treated twice for high fever, hepatosplenomegaly and leukopenia that were very similar to the present illness, 13 and 3 years before the onset and hepatosplenomegaly had been noted by the patient for 13 years. The patient died after a rapid course of 20 days. Histiocytic medullary reticulosis (HMR) was diagnosed at the autopsy, which revealed atypical histiocytic infiltration showing erythrophagocytosis in the liver, spleen, left adrenal, and mesenterial and pulmonary hilar lymph nodes. This patient had shown the same clinical signs and hepatosplenomegaly 13 years before the onset of HMR, which suggest a possible latent stage and acute exacerbation of HMR.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>3418986</pmid><doi>10.2169/internalmedicine1962.27.195</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-5120 |
| ispartof | Japanese Journal of Medicine, 1988, Vol.27(2), pp.195-199 |
| issn | 0021-5120 1881-123X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78408128 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Autopsy Hepatomegaly - complications Hepatomegaly - pathology Histiocytic Sarcoma - complications Histiocytic Sarcoma - diagnosis Histiocytic Sarcoma - pathology Hodgkin's disease Humans Male Malignant histiocytosis Splenomegaly - complications Splenomegaly - pathology |
| title | An Autopsy Case of Histiocytic Medullary Reticulosis Presenting with Marked Hepatosplenomegaly for 13 Years before the Onset |
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