Influence of Macrogol Bases on the Bioavailability of Bacampicillin after Rectal Administration in Rabbits

Rectal administration of bacampicillin hydrochloride (BAPC) in Witepsol H-15 base suppository provided a fairly good absorption in rabbits; the extent of bioavaliability was 44%. Since BAPC has high lipophilicity compared to the parent compound (ampicillin, ABPC), rectal absorption from hydrophilic...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1988/04/25, Vol.36(4), pp.1475-1482
Hauptverfasser:	KAWASHIMA, SUSUMU, NAKAZAWA, HAYATO, FUJIWARA, HIROSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Rectal Ampicillin - administration & dosage Ampicillin - analogs & derivatives Ampicillin - pharmacokinetics Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Biological Availability Excipients Male Medical sciences Pharmacology. Drug treatments Polyethylene Glycols Rabbits rectal fluid secretion Suppositories
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