Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA
Mitochondrial DNA (mtDNA) is maternally inherited in mammals. Despite the high genome copy number in mature oocytes (10 5 ) and the relatively small number of cell divisions in the female germline, mtDNA sequence variants segregate rapidly between generations. To investigate the molecular basis for...
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| Veröffentlicht in: | Nature genetics 1996-10, Vol.14 (2), p.146-151 |
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| creator | Jenuth, Jack P. Peterson, Alan C. Fu, Katherine Shoubridge, Eric A. |
| description | Mitochondrial DNA (mtDNA) is maternally inherited in mammals. Despite the high genome copy number in mature oocytes (10
5
) and the relatively small number of cell divisions in the female germline, mtDNA sequence variants segregate rapidly between generations. To investigate the molecular basis for this apparent paradox we created lines of heteroplasmic mice carrying two mtDNA genotypes. We show that the pattern of segregation can be explained by random genetic drift ocurring in early oogenesis, and that the effective number of segregating units for mtDNA is ∼200 in mice. These results provide the basis for estimating recurrence risks for mitochondrial disease due to pathogenic mtDNA mutations and for predicting the rate of fixation of neutral mtDNA mutations in maternal lineages. |
| doi_str_mv | 10.1038/ng1096-146 |
| format | Article |
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5
) and the relatively small number of cell divisions in the female germline, mtDNA sequence variants segregate rapidly between generations. To investigate the molecular basis for this apparent paradox we created lines of heteroplasmic mice carrying two mtDNA genotypes. We show that the pattern of segregation can be explained by random genetic drift ocurring in early oogenesis, and that the effective number of segregating units for mtDNA is ∼200 in mice. These results provide the basis for estimating recurrence risks for mitochondrial disease due to pathogenic mtDNA mutations and for predicting the rate of fixation of neutral mtDNA mutations in maternal lineages.</description><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Female</subject><subject>Founder Effect</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Dosage</subject><subject>Gene Frequency</subject><subject>Gene Function</subject><subject>Genetics of eukaryotes. 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Psychology</topic><topic>Gene Dosage</topic><topic>Gene Frequency</topic><topic>Gene Function</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype</topic><topic>Human Genetics</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred NZB</topic><topic>Oocytes</topic><topic>Oogenesis - genetics</topic><topic>Oogonia</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jenuth, Jack P.</creatorcontrib><creatorcontrib>Peterson, Alan C.</creatorcontrib><creatorcontrib>Fu, Katherine</creatorcontrib><creatorcontrib>Shoubridge, Eric A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jenuth, Jack P.</au><au>Peterson, Alan C.</au><au>Fu, Katherine</au><au>Shoubridge, Eric A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>14</volume><issue>2</issue><spage>146</spage><epage>151</epage><pages>146-151</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>Mitochondrial DNA (mtDNA) is maternally inherited in mammals. Despite the high genome copy number in mature oocytes (10
5
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| ispartof | Nature genetics, 1996-10, Vol.14 (2), p.146-151 |
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| subjects | Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Classical genetics, quantitative genetics, hybrids DNA, Mitochondrial - genetics Female Founder Effect Fundamental and applied biological sciences. Psychology Gene Dosage Gene Frequency Gene Function Genetics of eukaryotes. Biological and molecular evolution Genotype Human Genetics Mice Mice, Inbred BALB C Mice, Inbred NZB Oocytes Oogenesis - genetics Oogonia Vertebrata |
| title | Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA |
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