Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor

In order to stabilize the C‐terminal dodecapeptide of neuropeptide Y (NPY) we replaced Leu28 and Thr32 by Lys and Glu, respectively, and subsequently linked these residues by lactamization. This peptide analog of NPY shows a more than 100‐fold increase in affinity compared to the C‐terminal linear d...

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Veröffentlicht in:	FEBS letters 1996-09, Vol.394 (2), p.169-173
Hauptverfasser:	Rist, Beate, Zerbe, Oliver, Ingenhoven, Nikolaus, Scapozza, Leonardo, Peers, Chris, Vaughan, Peter F.T, McDonald, Ruth L, Wieland, Heike A, Beck-Sickinger, Annette G
Format:	Artikel
Sprache:	eng
Schlagworte:	6-aminohexanoic acid Ahx Amino Acid Sequence Bioactive conformation Calcium - metabolism Calcium Channels - metabolism fluoren-9-ylmethoxycarbonyl Fmoc Humans Magnetic Resonance Spectroscopy Models, Molecular Neuroblastoma Neuropeptide Y Neuropeptide Y - analogs & derivatives Neuropeptide Y - chemistry Neuropeptide Y - metabolism Neuropeptide Y - pharmacology NMR NPY Patch-Clamp Techniques Peptide Fragments - chemistry Peptide Fragments - metabolism Peptide Fragments - pharmacology Peptide synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Peptides, Cyclic - pharmacology Protein Structure, Secondary Receptor binding Receptors, Neuropeptide Y - agonists Receptors, Neuropeptide Y - metabolism Tumor Cells, Cultured
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