Transfer of a functional human immune system to mice with severe combined immunodeficiency

The pressing need for a better experimental system for AIDS research has brought into sharp focus the shortcomings of available animal models and the practical and ethical limitations of studies of immune responses and viral pathogenesis in humans. Current studies of the human immune responses are l...

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Veröffentlicht in:	Nature (London) 1988-09, Vol.335 (6187), p.256-259
Hauptverfasser:	Mosier, Donald E, Gulizia, Richard J, Baird, Stephen M, Wilson, Darcy B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS/HIV Animal models Animals Antibody Formation Biological and medical sciences Cellular biology Disease Models, Animal Experimental and animal immunopathology. Animal models Humans Immune response Immune system Immunity (Disease) Immunity, Cellular Immunization Immunologic Deficiency Syndromes - veterinary Immunopathology Injection Lymphocyte Transfusion Medical research Medical sciences Mice T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - immunology Tetanus Toxoid - immunology Transplantation, Heterologous
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