Prevalence of HTLV type I infection in Iran : A serological and genetic study
Several publications describe the presence of the human T cell lymphotropic virus type I (HTLV-I) in Jewish individuals born in Mash-had, Iran. We report here the results of HTLV-I serological and genetic studies in the non-Jewish population of Mash-had as well as a neighboring area: Gonbad-Kavous....
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| Veröffentlicht in: | AIDS research and human retroviruses 1996-08, Vol.12 (12), p.1185-1190 |
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| container_title | AIDS research and human retroviruses |
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| creator | SAFAI, B HUANG, J.-L BOERI, E FARID, R RAAFAT, J SCHUTZER, P AHKAMI, R FRANCHINI, G |
| description | Several publications describe the presence of the human T cell lymphotropic virus type I (HTLV-I) in Jewish individuals born in Mash-had, Iran. We report here the results of HTLV-I serological and genetic studies in the non-Jewish population of Mash-had as well as a neighboring area: Gonbad-Kavous. Seven hundred and seven serum samples from Mash-had (694 healthy individuals and 13 patients with lymphoma) and 90 from Gonbad-Kavous were tested for HTLV antibodies by gelatin particle agglutination assay (PA) and confirmatory Western blots (WBs). Seropositive rates of 3.0% (21 of 694) in Mash-had, 0% (0 of 90) in Gonbad-Kavous, and 100% (13 of 13) in lymphoma cases were observed. HTLV-I DNA sequence were amplified by polymerase chain reaction directly from the fresh PBMCs of seropositive individuals. Phylogenetic analysis of the viral DNA sequence indicated that the HTLV-I present in Mash-had belong to the HTLV-I cosmopolitan clade. Altogether, these data indicate that Mash-had, located in northeastern Iran, is a newly recognized endemic center for HTLV-I. |
| doi_str_mv | 10.1089/aid.1996.12.1185 |
| format | Article |
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We report here the results of HTLV-I serological and genetic studies in the non-Jewish population of Mash-had as well as a neighboring area: Gonbad-Kavous. Seven hundred and seven serum samples from Mash-had (694 healthy individuals and 13 patients with lymphoma) and 90 from Gonbad-Kavous were tested for HTLV antibodies by gelatin particle agglutination assay (PA) and confirmatory Western blots (WBs). Seropositive rates of 3.0% (21 of 694) in Mash-had, 0% (0 of 90) in Gonbad-Kavous, and 100% (13 of 13) in lymphoma cases were observed. HTLV-I DNA sequence were amplified by polymerase chain reaction directly from the fresh PBMCs of seropositive individuals. Phylogenetic analysis of the viral DNA sequence indicated that the HTLV-I present in Mash-had belong to the HTLV-I cosmopolitan clade. Altogether, these data indicate that Mash-had, located in northeastern Iran, is a newly recognized endemic center for HTLV-I.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.1996.12.1185</identifier><identifier>PMID: 8844023</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; HTLV-I Infections - blood ; HTLV-I Infections - epidemiology ; HTLV-I Infections - ethnology ; HTLV-I Infections - genetics ; Human T-lymphotropic virus 1 - genetics ; Human T-lymphotropic virus 1 - isolation & purification ; Human viral diseases ; Humans ; Infectious diseases ; Iran ; Jews ; Medical sciences ; Molecular Sequence Data ; Serologic Tests ; Tropical medicine ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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We report here the results of HTLV-I serological and genetic studies in the non-Jewish population of Mash-had as well as a neighboring area: Gonbad-Kavous. Seven hundred and seven serum samples from Mash-had (694 healthy individuals and 13 patients with lymphoma) and 90 from Gonbad-Kavous were tested for HTLV antibodies by gelatin particle agglutination assay (PA) and confirmatory Western blots (WBs). Seropositive rates of 3.0% (21 of 694) in Mash-had, 0% (0 of 90) in Gonbad-Kavous, and 100% (13 of 13) in lymphoma cases were observed. HTLV-I DNA sequence were amplified by polymerase chain reaction directly from the fresh PBMCs of seropositive individuals. Phylogenetic analysis of the viral DNA sequence indicated that the HTLV-I present in Mash-had belong to the HTLV-I cosmopolitan clade. Altogether, these data indicate that Mash-had, located in northeastern Iran, is a newly recognized endemic center for HTLV-I.</description><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>HTLV-I Infections - blood</subject><subject>HTLV-I Infections - epidemiology</subject><subject>HTLV-I Infections - ethnology</subject><subject>HTLV-I Infections - genetics</subject><subject>Human T-lymphotropic virus 1 - genetics</subject><subject>Human T-lymphotropic virus 1 - isolation & purification</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Iran</subject><subject>Jews</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Serologic Tests</subject><subject>Tropical medicine</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAFAI, B</creatorcontrib><creatorcontrib>HUANG, J.-L</creatorcontrib><creatorcontrib>BOERI, E</creatorcontrib><creatorcontrib>FARID, R</creatorcontrib><creatorcontrib>RAAFAT, J</creatorcontrib><creatorcontrib>SCHUTZER, P</creatorcontrib><creatorcontrib>AHKAMI, R</creatorcontrib><creatorcontrib>FRANCHINI, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAFAI, B</au><au>HUANG, J.-L</au><au>BOERI, E</au><au>FARID, R</au><au>RAAFAT, J</au><au>SCHUTZER, P</au><au>AHKAMI, R</au><au>FRANCHINI, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of HTLV type I infection in Iran : A serological and genetic study</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>1996-08-10</date><risdate>1996</risdate><volume>12</volume><issue>12</issue><spage>1185</spage><epage>1190</epage><pages>1185-1190</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>Several publications describe the presence of the human T cell lymphotropic virus type I (HTLV-I) in Jewish individuals born in Mash-had, Iran. We report here the results of HTLV-I serological and genetic studies in the non-Jewish population of Mash-had as well as a neighboring area: Gonbad-Kavous. Seven hundred and seven serum samples from Mash-had (694 healthy individuals and 13 patients with lymphoma) and 90 from Gonbad-Kavous were tested for HTLV antibodies by gelatin particle agglutination assay (PA) and confirmatory Western blots (WBs). Seropositive rates of 3.0% (21 of 694) in Mash-had, 0% (0 of 90) in Gonbad-Kavous, and 100% (13 of 13) in lymphoma cases were observed. HTLV-I DNA sequence were amplified by polymerase chain reaction directly from the fresh PBMCs of seropositive individuals. Phylogenetic analysis of the viral DNA sequence indicated that the HTLV-I present in Mash-had belong to the HTLV-I cosmopolitan clade. Altogether, these data indicate that Mash-had, located in northeastern Iran, is a newly recognized endemic center for HTLV-I.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>8844023</pmid><doi>10.1089/aid.1996.12.1185</doi><tpages>6</tpages></addata></record> |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | AIDS/HIV Amino Acid Sequence Base Sequence Biological and medical sciences HTLV-I Infections - blood HTLV-I Infections - epidemiology HTLV-I Infections - ethnology HTLV-I Infections - genetics Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - isolation & purification Human viral diseases Humans Infectious diseases Iran Jews Medical sciences Molecular Sequence Data Serologic Tests Tropical medicine Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Prevalence of HTLV type I infection in Iran : A serological and genetic study |
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