polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila
Reduction of wild-type activity of the polychaetoid (pyd) gene results in formation of extra mechanosensory bristles on the head and notum of adult Drosophila. Loss of pyd function results in decreased ability to restrict sensory organ precursor (SOP) formation to a single cell per proneural cluster...
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| Veröffentlicht in: | Mechanisms of development 1996-07, Vol.57 (2), p.215-227 |
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| container_title | Mechanisms of development |
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| creator | Chen, Chiann-Mun Freedman, Jennifer A. Bettler, Donald R. Manning, Sharon D. Giep, Son N. Steiner, Julia Ellis, Hilary M. |
| description | Reduction of wild-type activity of the polychaetoid (pyd) gene results in formation of extra mechanosensory bristles on the head and notum of adult Drosophila. Loss of pyd function results in decreased ability to restrict sensory organ precursor (SOP) formation to a single cell per proneural cluster. Although the initial proneural cluster pattern of achaete expression is not altered in pyd mutants extra cells within proneural clusters express the high levels of achaete characteristic of SOPs. This observation suggests that pyd+ functions as a negative regulator of achaete-scute complex expression within the proneural cluster. Synergistic interactions between pyd and Notch, Delta and extramacrochaetae mutations support this model. We also demonstrate that pyd is required for normal eye development. |
| doi_str_mv | 10.1016/0925-4773(96)00548-5 |
| format | Article |
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Loss of pyd function results in decreased ability to restrict sensory organ precursor (SOP) formation to a single cell per proneural cluster. Although the initial proneural cluster pattern of achaete expression is not altered in pyd mutants extra cells within proneural clusters express the high levels of achaete characteristic of SOPs. This observation suggests that pyd+ functions as a negative regulator of achaete-scute complex expression within the proneural cluster. Synergistic interactions between pyd and Notch, Delta and extramacrochaetae mutations support this model. We also demonstrate that pyd is required for normal eye development.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/0925-4773(96)00548-5</identifier><identifier>PMID: 8843398</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Alleles ; Animals ; Drosophila ; Drosophila - embryology ; Embryo, Nonmammalian - embryology ; Gene Expression Regulation, Developmental - physiology ; Genes, Insect ; Models, Genetic ; Nervous System - embryology ; polychaetoid ; Proneural cluster ; Sense Organs - embryology ; Sensory organ precursor ; Space life sciences</subject><ispartof>Mechanisms of development, 1996-07, Vol.57 (2), p.215-227</ispartof><rights>1996</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-ea29379c06c1b0325b1742aba95074bbd30068b8d08aa1ecac5e3bdf82672d933</citedby><cites>FETCH-LOGICAL-c403t-ea29379c06c1b0325b1742aba95074bbd30068b8d08aa1ecac5e3bdf82672d933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0925-4773(96)00548-5$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8843398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Chiann-Mun</creatorcontrib><creatorcontrib>Freedman, Jennifer A.</creatorcontrib><creatorcontrib>Bettler, Donald R.</creatorcontrib><creatorcontrib>Manning, Sharon D.</creatorcontrib><creatorcontrib>Giep, Son N.</creatorcontrib><creatorcontrib>Steiner, Julia</creatorcontrib><creatorcontrib>Ellis, Hilary M.</creatorcontrib><title>polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>Reduction of wild-type activity of the polychaetoid (pyd) gene results in formation of extra mechanosensory bristles on the head and notum of adult Drosophila. Loss of pyd function results in decreased ability to restrict sensory organ precursor (SOP) formation to a single cell per proneural cluster. Although the initial proneural cluster pattern of achaete expression is not altered in pyd mutants extra cells within proneural clusters express the high levels of achaete characteristic of SOPs. This observation suggests that pyd+ functions as a negative regulator of achaete-scute complex expression within the proneural cluster. Synergistic interactions between pyd and Notch, Delta and extramacrochaetae mutations support this model. We also demonstrate that pyd is required for normal eye development.</description><subject>Alleles</subject><subject>Animals</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Embryo, Nonmammalian - embryology</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Genes, Insect</subject><subject>Models, Genetic</subject><subject>Nervous System - embryology</subject><subject>polychaetoid</subject><subject>Proneural cluster</subject><subject>Sense Organs - embryology</subject><subject>Sensory organ precursor</subject><subject>Space life sciences</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOl7eQCEr0UX1pGmbZCOIdxDc6DqkyekY6TRj0grz9maYwaWr5D_nP7ePkFMGVwxYcw2qrItKCH6hmkuAupJFvUNmTIqyaHjd7JLZn-WAHKb0BQCMNWyf7EtZca7kjMRl6Ff20-AYvKM-0Yjfk4_o6BjyP43R25EmnEecm9GHgYYuyyGFuKIhzs1AlxHtFHMg0S6GRdZhwCmantp-SiPmuB_ofQwpLD99b47JXmf6hCfb94h8PD683z0Xr29PL3e3r4WtgI8FmlJxoSw0lrXAy7ploipNa1QNompbxwEa2UoH0hiG1tgaees6WTaidIrzI3K-6ZsX-p7yKXrhk8W-NwOGKWkhuRIMVDZWG6PNO6aInV5GvzBxpRnoNWq95qjXHLXKYo1a17nsbNt_ahfo_oq2bHP-ZpPHfOSPx6iT9ThYdJmvHbUL_v8Bvx6-kLk</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Chen, Chiann-Mun</creator><creator>Freedman, Jennifer A.</creator><creator>Bettler, Donald R.</creator><creator>Manning, Sharon D.</creator><creator>Giep, Son N.</creator><creator>Steiner, Julia</creator><creator>Ellis, Hilary M.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila</title><author>Chen, Chiann-Mun ; Freedman, Jennifer A. ; Bettler, Donald R. ; Manning, Sharon D. ; Giep, Son N. ; Steiner, Julia ; Ellis, Hilary M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-ea29379c06c1b0325b1742aba95074bbd30068b8d08aa1ecac5e3bdf82672d933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Drosophila</topic><topic>Drosophila - embryology</topic><topic>Embryo, Nonmammalian - embryology</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Genes, Insect</topic><topic>Models, Genetic</topic><topic>Nervous System - embryology</topic><topic>polychaetoid</topic><topic>Proneural cluster</topic><topic>Sense Organs - embryology</topic><topic>Sensory organ precursor</topic><topic>Space life sciences</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chiann-Mun</creatorcontrib><creatorcontrib>Freedman, Jennifer A.</creatorcontrib><creatorcontrib>Bettler, Donald R.</creatorcontrib><creatorcontrib>Manning, Sharon D.</creatorcontrib><creatorcontrib>Giep, Son N.</creatorcontrib><creatorcontrib>Steiner, Julia</creatorcontrib><creatorcontrib>Ellis, Hilary M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chiann-Mun</au><au>Freedman, Jennifer A.</au><au>Bettler, Donald R.</au><au>Manning, Sharon D.</au><au>Giep, Son N.</au><au>Steiner, Julia</au><au>Ellis, Hilary M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>57</volume><issue>2</issue><spage>215</spage><epage>227</epage><pages>215-227</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><abstract>Reduction of wild-type activity of the polychaetoid (pyd) gene results in formation of extra mechanosensory bristles on the head and notum of adult Drosophila. 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| ispartof | Mechanisms of development, 1996-07, Vol.57 (2), p.215-227 |
| issn | 0925-4773 1872-6356 |
| language | eng |
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| source | ScienceDirect; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Alleles Animals Drosophila Drosophila - embryology Embryo, Nonmammalian - embryology Gene Expression Regulation, Developmental - physiology Genes, Insect Models, Genetic Nervous System - embryology polychaetoid Proneural cluster Sense Organs - embryology Sensory organ precursor Space life sciences |
| title | polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila |
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