Pathophysiology of itching
Itching is the predominant symptom of skin disease but it is ill-understood and a challenge for future research. Even the major nerve pathways for itch, and its relationship to pain are debatable. In inflamed skin, histamine plays a major role and its mode of release from mast cells in, for example,...
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| Veröffentlicht in: | The Lancet (British edition) 1996-10, Vol.348 (9032), p.938-940 |
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| creator | Greaves, MW Wall, PD |
| description | Itching is the predominant symptom of skin disease but it is ill-understood and a challenge for future research. Even the major nerve pathways for itch, and its relationship to pain are debatable. In inflamed skin, histamine plays a major role and its mode of release from mast cells in, for example, chronic urticaria is now better appreciated. Tachykinins including substance P and cytokines including interleukin-2 are evidently important peripherally. Opioid u-receptor-dependent processes activate inhibitory circuits in the central nervous system and regulate the extent of intensity and quality of perceived itch. It is proposed that stimulation of large areas of skin such as by scratching, generates inhibitory activity which suppresses itch excitation. Therapeutic intervention based upon understanding these regulatory processes is a real prospect. |
| doi_str_mv | 10.1016/S0140-6736(96)04328-0 |
| format | Article |
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Even the major nerve pathways for itch, and its relationship to pain are debatable. In inflamed skin, histamine plays a major role and its mode of release from mast cells in, for example, chronic urticaria is now better appreciated. Tachykinins including substance P and cytokines including interleukin-2 are evidently important peripherally. Opioid u-receptor-dependent processes activate inhibitory circuits in the central nervous system and regulate the extent of intensity and quality of perceived itch. It is proposed that stimulation of large areas of skin such as by scratching, generates inhibitory activity which suppresses itch excitation. 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Even the major nerve pathways for itch, and its relationship to pain are debatable. In inflamed skin, histamine plays a major role and its mode of release from mast cells in, for example, chronic urticaria is now better appreciated. Tachykinins including substance P and cytokines including interleukin-2 are evidently important peripherally. Opioid u-receptor-dependent processes activate inhibitory circuits in the central nervous system and regulate the extent of intensity and quality of perceived itch. It is proposed that stimulation of large areas of skin such as by scratching, generates inhibitory activity which suppresses itch excitation. 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| ispartof | The Lancet (British edition), 1996-10, Vol.348 (9032), p.938-940 |
| issn | 0140-6736 1474-547X |
| language | eng |
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| source | MEDLINE; EBSCOhost Business Source Complete; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Biological and medical sciences Central nervous system Cytokines Dermatitis Dermatology Gallbladder diseases Histamine Humans Medical sciences Narcotics Nervous system Neuropeptides Pain Pathophysiology Peptides Pruritus - etiology Pruritus - physiopathology Skin diseases Skin involvement in other diseases. Miscellaneous. General aspects Systemic diseases Urticaria |
| title | Pathophysiology of itching |
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