Physical Characterization of the Hydrates of Urapidil
Three hydrates of urapidil were prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rates, and solution calorimetry. The stoichiometry of the urapidil hydrates was found to be 1:5...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1988-05, Vol.77 (5), p.444-451 |
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| container_end_page | 451 |
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| container_issue | 5 |
| container_start_page | 444 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 77 |
| creator | Botha, S.A. Caira, M.R. Guillory, J.K. Lötter, A.P. |
| description | Three hydrates of urapidil were prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rates, and solution calorimetry. The stoichiometry of the urapidil hydrates was found to be 1:5, 1:3, and 1:1 (urapidiliwater). The crystal and molecular structures of urapidil pentahydrate were determined from three-dimensional X-ray data. The stability of the pentahydrate and monohydrate under different storage conditions was also determined. |
| doi_str_mv | 10.1002/jps.2600770518 |
| format | Article |
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The stoichiometry of the urapidil hydrates was found to be 1:5, 1:3, and 1:1 (urapidiliwater). The crystal and molecular structures of urapidil pentahydrate were determined from three-dimensional X-ray data. The stability of the pentahydrate and monohydrate under different storage conditions was also determined.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600770518</identifier><identifier>PMID: 3411469</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; Crystallography ; Differential Thermal Analysis ; Drug Stability ; General pharmacology ; Medical sciences ; Microscopy, Electron, Scanning ; Pharmacology. Drug treatments ; Physicochemical properties. 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Pharm. Sci</addtitle><description>Three hydrates of urapidil were prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rates, and solution calorimetry. The stoichiometry of the urapidil hydrates was found to be 1:5, 1:3, and 1:1 (urapidiliwater). The crystal and molecular structures of urapidil pentahydrate were determined from three-dimensional X-ray data. The stability of the pentahydrate and monohydrate under different storage conditions was also determined.</description><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Crystallography</subject><subject>Differential Thermal Analysis</subject><subject>Drug Stability</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. Structure-activity relationships</subject><subject>Piperazines - analysis</subject><subject>Solubility</subject><subject>Spectrophotometry, Infrared</subject><subject>Stereoisomerism</subject><subject>X-Ray Diffraction</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEURS1UBCl0yw4pi4rdhOfvmWUVQUKJAAlQl5bteaOYTjKpPaFNfz2TTpSqi4qVZd1z37MPIWcURhSAXb6s0ogpAK1B0vyADKhkkCmg-gMZdADLuBTFMfmY0gsAKJDyiBxxQalQxYDIh_kmBW_r4Xhuo_UtxvDbtqFZDptq2M5xON2U0baYtvfnaFehDPUpOaxsnfDT7jwhz9dXT-NpNruf3Iy_zDIvpMozrtEDo4wKDZoXTiPXzOeVdNY5aZmSJSjexbnzrqCgWAFaKa-dQ4GO8RNy0c9dxebHGlNrFiF5rGu7xGadjM55ITSXHTjqQR-blCJWZhXDwsaNoWC2nkznyfz11BXOd5PXboHlHt-J6fLPu9ymzk4V7dKHtMd0Lhj9gxU99jPUuHlnqfn68PjPE7K-G1KLv_ZdG78bpbmW5tvdxIgnMWNwq8x2V97z2Bl_DRhN8gGXHssQ0bembML_fvsGnFCgiA</recordid><startdate>198805</startdate><enddate>198805</enddate><creator>Botha, S.A.</creator><creator>Caira, M.R.</creator><creator>Guillory, J.K.</creator><creator>Lötter, A.P.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198805</creationdate><title>Physical Characterization of the Hydrates of Urapidil</title><author>Botha, S.A. ; Caira, M.R. ; Guillory, J.K. ; Lötter, A.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4568-37ec02121470739b7e372c8f5babb5a265d0632148bcb9106290766c7bbe4eb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Crystallography</topic><topic>Differential Thermal Analysis</topic><topic>Drug Stability</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>Piperazines - analysis</topic><topic>Solubility</topic><topic>Spectrophotometry, Infrared</topic><topic>Stereoisomerism</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Botha, S.A.</creatorcontrib><creatorcontrib>Caira, M.R.</creatorcontrib><creatorcontrib>Guillory, J.K.</creatorcontrib><creatorcontrib>Lötter, A.P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Botha, S.A.</au><au>Caira, M.R.</au><au>Guillory, J.K.</au><au>Lötter, A.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical Characterization of the Hydrates of Urapidil</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1988-05</date><risdate>1988</risdate><volume>77</volume><issue>5</issue><spage>444</spage><epage>451</epage><pages>444-451</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>Three hydrates of urapidil were prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rates, and solution calorimetry. The stoichiometry of the urapidil hydrates was found to be 1:5, 1:3, and 1:1 (urapidiliwater). The crystal and molecular structures of urapidil pentahydrate were determined from three-dimensional X-ray data. The stability of the pentahydrate and monohydrate under different storage conditions was also determined.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>3411469</pmid><doi>10.1002/jps.2600770518</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1988-05, Vol.77 (5), p.444-451 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Chemical Phenomena Chemistry, Physical Crystallography Differential Thermal Analysis Drug Stability General pharmacology Medical sciences Microscopy, Electron, Scanning Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Piperazines - analysis Solubility Spectrophotometry, Infrared Stereoisomerism X-Ray Diffraction |
| title | Physical Characterization of the Hydrates of Urapidil |
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