Erythrocyte incorporation of ingested 58-iron by infants
The least abundant stable isotope of iron, 58Fe (natural abundance 0.322 weight %), was administered orally to infants to explore the feasibility of using a stable rather than a radioisotope in studies of iron absorption. The dose of 58Fe was given between feedings at age 126 days. The mass isotope...
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| Veröffentlicht in: | Pediatric research 1988-07, Vol.24 (1), p.20-24 |
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| container_title | Pediatric research |
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| creator | FOMON, S. J JANGHORBANI, M TING, B. T. G ZIEGLER, E. E ROGERS, R. R NELSON, S. E OSTEDGAARD, L. S EDWARDS, B. B |
| description | The least abundant stable isotope of iron, 58Fe (natural abundance 0.322 weight %), was administered orally to infants to explore the feasibility of using a stable rather than a radioisotope in studies of iron absorption. The dose of 58Fe was given between feedings at age 126 days. The mass isotope ratio, 58Fe/57Fe, was determined in blood by inductively coupled plasma mass spectroscopy and at ages 140, 168, and 196 days. The percentage of the 58Fe dose entering the circulation (3.2 to 16.0%) was inversely correlated with serum ferritin concentration (r = -0.867, p less than 0.01). For individual infants the SD of the percentage of administered dose of iron appearing in the circulation ranged from 0.22 to 1.28. We conclude that the method is likely to be suitable for within-subject comparisons of iron availability from foods. Because of the large between-subject variation, we are pessimistic for this age group about the usefulness of study designs based on group comparisons. |
| doi_str_mv | 10.1203/00006450-198807000-00006 |
| format | Article |
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J ; JANGHORBANI, M ; TING, B. T. G ; ZIEGLER, E. E ; ROGERS, R. R ; NELSON, S. E ; OSTEDGAARD, L. S ; EDWARDS, B. B</creator><creatorcontrib>FOMON, S. J ; JANGHORBANI, M ; TING, B. T. G ; ZIEGLER, E. E ; ROGERS, R. R ; NELSON, S. E ; OSTEDGAARD, L. S ; EDWARDS, B. B</creatorcontrib><description>The least abundant stable isotope of iron, 58Fe (natural abundance 0.322 weight %), was administered orally to infants to explore the feasibility of using a stable rather than a radioisotope in studies of iron absorption. The dose of 58Fe was given between feedings at age 126 days. The mass isotope ratio, 58Fe/57Fe, was determined in blood by inductively coupled plasma mass spectroscopy and at ages 140, 168, and 196 days. The percentage of the 58Fe dose entering the circulation (3.2 to 16.0%) was inversely correlated with serum ferritin concentration (r = -0.867, p less than 0.01). For individual infants the SD of the percentage of administered dose of iron appearing in the circulation ranged from 0.22 to 1.28. We conclude that the method is likely to be suitable for within-subject comparisons of iron availability from foods. Because of the large between-subject variation, we are pessimistic for this age group about the usefulness of study designs based on group comparisons.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/00006450-198807000-00006</identifier><identifier>PMID: 3412846</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Absorption ; Aging - blood ; Biological and medical sciences ; Biological Availability ; Erythrocytes - metabolism ; Ferritins - blood ; Humans ; Infant ; Infant, Newborn ; Iron - pharmacokinetics ; Iron Isotopes ; Medical sciences ; Nutritional Status ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><ispartof>Pediatric research, 1988-07, Vol.24 (1), p.20-24</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-868b5e3aba951a84bd343cff72c922b9b5ddf2872bc5402725793ab9fe899c773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19563808$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3412846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FOMON, S. J</creatorcontrib><creatorcontrib>JANGHORBANI, M</creatorcontrib><creatorcontrib>TING, B. T. G</creatorcontrib><creatorcontrib>ZIEGLER, E. E</creatorcontrib><creatorcontrib>ROGERS, R. R</creatorcontrib><creatorcontrib>NELSON, S. E</creatorcontrib><creatorcontrib>OSTEDGAARD, L. S</creatorcontrib><creatorcontrib>EDWARDS, B. B</creatorcontrib><title>Erythrocyte incorporation of ingested 58-iron by infants</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>The least abundant stable isotope of iron, 58Fe (natural abundance 0.322 weight %), was administered orally to infants to explore the feasibility of using a stable rather than a radioisotope in studies of iron absorption. The dose of 58Fe was given between feedings at age 126 days. The mass isotope ratio, 58Fe/57Fe, was determined in blood by inductively coupled plasma mass spectroscopy and at ages 140, 168, and 196 days. The percentage of the 58Fe dose entering the circulation (3.2 to 16.0%) was inversely correlated with serum ferritin concentration (r = -0.867, p less than 0.01). For individual infants the SD of the percentage of administered dose of iron appearing in the circulation ranged from 0.22 to 1.28. We conclude that the method is likely to be suitable for within-subject comparisons of iron availability from foods. Because of the large between-subject variation, we are pessimistic for this age group about the usefulness of study designs based on group comparisons.</description><subject>Absorption</subject><subject>Aging - blood</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Erythrocytes - metabolism</subject><subject>Ferritins - blood</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Iron - pharmacokinetics</subject><subject>Iron Isotopes</subject><subject>Medical sciences</subject><subject>Nutritional Status</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EKqXwCUjZwC7gZzxeoqoFpEpsYB3Zjg1BaVzsdJG_x9BQZjOaM3ceuggVBN8Ritk9zlFxgUuiALDMVfmLTtCcCJYLzuUpmmPMSMmUgnN0kdInxoQL4DM0Y5xQ4NUcwSqOw0cMdhxc0fY2xF2IemhDXwSfwbtLg2sKAWUbMzNjZl73Q7pEZ153yV1NeYHe1qvX5VO5eXl8Xj5sSssUHkqowAjHtNFKEA3cNIwz672kVlFqlBFN4ylIaqzgmEoqpMpq5R0oZaVkC3R72LuL4Wufv6m3bbKu63Tvwj7VEpjigqkshIPQxpBSdL7exXar41gTXP-YVv-ZVh9NO6A8ej3d2Juta46Dk0u5fzP1dbK681H3tk3_-5WoGGBg335Sc2w</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>FOMON, S. J</creator><creator>JANGHORBANI, M</creator><creator>TING, B. T. G</creator><creator>ZIEGLER, E. E</creator><creator>ROGERS, R. R</creator><creator>NELSON, S. E</creator><creator>OSTEDGAARD, L. S</creator><creator>EDWARDS, B. B</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880701</creationdate><title>Erythrocyte incorporation of ingested 58-iron by infants</title><author>FOMON, S. J ; JANGHORBANI, M ; TING, B. T. G ; ZIEGLER, E. E ; ROGERS, R. R ; NELSON, S. E ; OSTEDGAARD, L. S ; EDWARDS, B. B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-868b5e3aba951a84bd343cff72c922b9b5ddf2872bc5402725793ab9fe899c773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Absorption</topic><topic>Aging - blood</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Erythrocytes - metabolism</topic><topic>Ferritins - blood</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Iron - pharmacokinetics</topic><topic>Iron Isotopes</topic><topic>Medical sciences</topic><topic>Nutritional Status</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FOMON, S. J</creatorcontrib><creatorcontrib>JANGHORBANI, M</creatorcontrib><creatorcontrib>TING, B. T. G</creatorcontrib><creatorcontrib>ZIEGLER, E. E</creatorcontrib><creatorcontrib>ROGERS, R. R</creatorcontrib><creatorcontrib>NELSON, S. E</creatorcontrib><creatorcontrib>OSTEDGAARD, L. S</creatorcontrib><creatorcontrib>EDWARDS, B. B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FOMON, S. J</au><au>JANGHORBANI, M</au><au>TING, B. T. G</au><au>ZIEGLER, E. E</au><au>ROGERS, R. R</au><au>NELSON, S. E</au><au>OSTEDGAARD, L. S</au><au>EDWARDS, B. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erythrocyte incorporation of ingested 58-iron by infants</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>24</volume><issue>1</issue><spage>20</spage><epage>24</epage><pages>20-24</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>The least abundant stable isotope of iron, 58Fe (natural abundance 0.322 weight %), was administered orally to infants to explore the feasibility of using a stable rather than a radioisotope in studies of iron absorption. The dose of 58Fe was given between feedings at age 126 days. The mass isotope ratio, 58Fe/57Fe, was determined in blood by inductively coupled plasma mass spectroscopy and at ages 140, 168, and 196 days. The percentage of the 58Fe dose entering the circulation (3.2 to 16.0%) was inversely correlated with serum ferritin concentration (r = -0.867, p less than 0.01). For individual infants the SD of the percentage of administered dose of iron appearing in the circulation ranged from 0.22 to 1.28. We conclude that the method is likely to be suitable for within-subject comparisons of iron availability from foods. Because of the large between-subject variation, we are pessimistic for this age group about the usefulness of study designs based on group comparisons.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3412846</pmid><doi>10.1203/00006450-198807000-00006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Absorption Aging - blood Biological and medical sciences Biological Availability Erythrocytes - metabolism Ferritins - blood Humans Infant Infant, Newborn Iron - pharmacokinetics Iron Isotopes Medical sciences Nutritional Status Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) |
| title | Erythrocyte incorporation of ingested 58-iron by infants |
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