The role of comparative pharmacokinetics in the planning of human dose escalation: the experience with diacetyldianhydrogalactitol
The pharmacokinetics of diacetyldianhydrogalactitol (DADAG) was compared in mice, rats, and humans. The ratios of human therapeutic dose (ThD) to the LD10 were 8 and 5 in mice and rats, respectively. The ratios of the corresponding AUCs of DADAG were 20 and 17, whereas those of dianhydrogalactitol (...
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Veröffentlicht in: | Cancer chemotherapy and pharmacology 1988-01, Vol.22 (2), p.109-113 |
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