Exhaled nitric oxide in childhood asthma
Endogenous synthesis of nitric oxide (NO) and its presence in exhaled air was observed in various species including humans. Particularly high levels were found in adults with bronchial asthma, possibly because of the underlying pulmonary inflammatory activity. We studied oral and nasal exhaled NO by...
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| Veröffentlicht in: | European journal of pediatrics 1996-08, Vol.155 (8), p.698-701 |
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| container_title | European journal of pediatrics |
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| creator | ARTLICH, A HAGENAH, J.-U JONAS, S AHRENS, P GORTNER, L |
| description | Endogenous synthesis of nitric oxide (NO) and its presence in exhaled air was observed in various species including humans. Particularly high levels were found in adults with bronchial asthma, possibly because of the underlying pulmonary inflammatory activity. We studied oral and nasal exhaled NO by chemiluminescence in 47 children aged between 6 and 10 years. Thirty children had bronchial asthma, 17 were healthy controls. In asthmatic children oral exhaled NO was 13.4 +/- 1.4 parts per billion (ppb) (mean +/- SEM), nasal exhaled NO was 21.7 +/- 1.5 ppb. In healthy controls oral exhaled NO was 7.2 +/0 1.0 ppb, nasal exhaled NO was 18.2 +/- 22 ppb. Oral exhaled NO was significantly higher in asthmatic children compared to healthy controls (P = 0.0017). Nasal exhaled NO did not differ significantly in the two groups. There was a significant negative correlation between oral exhaled NO and forced expiratory volume in 1 s (FeV1). No significant correlation between oral or nasal exhaled NO and other markers of obstructive lung function impairment, oral minute ventilation, the body mass index and the presence of upper respiratory tract infection could be found.
Children with bronchial asthma have significantly higher levels of orally exhaled nitric oxide than healthy controls. |
| doi_str_mv | 10.1007/BF01957156 |
| format | Article |
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Children with bronchial asthma have significantly higher levels of orally exhaled nitric oxide than healthy controls.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/BF01957156</identifier><identifier>PMID: 8839728</identifier><identifier>CODEN: EJPEDT</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Asthma ; Asthma - metabolism ; Biological and medical sciences ; Body mass ; Body mass index ; Breath Tests ; Chemiluminescence ; Child ; Childhood ; Children ; Chronic obstructive pulmonary disease, asthma ; Female ; Humans ; Inflammation ; Male ; Mechanical ventilation ; Medical sciences ; Nitric oxide ; Nitric Oxide - analysis ; Nitric Oxide - metabolism ; Pneumology ; Respiratory function ; Respiratory Function Tests ; Respiratory tract diseases</subject><ispartof>European journal of pediatrics, 1996-08, Vol.155 (8), p.698-701</ispartof><rights>1996 INIST-CNRS</rights><rights>Springer-Verlag 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-a90ca2457d3223af3b8fbc2b227e0e80161f427ffbe99e3672d389d9035a78793</citedby><cites>FETCH-LOGICAL-c339t-a90ca2457d3223af3b8fbc2b227e0e80161f427ffbe99e3672d389d9035a78793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23910,23911,25119,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3159252$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8839728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARTLICH, A</creatorcontrib><creatorcontrib>HAGENAH, J.-U</creatorcontrib><creatorcontrib>JONAS, S</creatorcontrib><creatorcontrib>AHRENS, P</creatorcontrib><creatorcontrib>GORTNER, L</creatorcontrib><title>Exhaled nitric oxide in childhood asthma</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><description>Endogenous synthesis of nitric oxide (NO) and its presence in exhaled air was observed in various species including humans. Particularly high levels were found in adults with bronchial asthma, possibly because of the underlying pulmonary inflammatory activity. We studied oral and nasal exhaled NO by chemiluminescence in 47 children aged between 6 and 10 years. Thirty children had bronchial asthma, 17 were healthy controls. In asthmatic children oral exhaled NO was 13.4 +/- 1.4 parts per billion (ppb) (mean +/- SEM), nasal exhaled NO was 21.7 +/- 1.5 ppb. In healthy controls oral exhaled NO was 7.2 +/0 1.0 ppb, nasal exhaled NO was 18.2 +/- 22 ppb. Oral exhaled NO was significantly higher in asthmatic children compared to healthy controls (P = 0.0017). Nasal exhaled NO did not differ significantly in the two groups. There was a significant negative correlation between oral exhaled NO and forced expiratory volume in 1 s (FeV1). No significant correlation between oral or nasal exhaled NO and other markers of obstructive lung function impairment, oral minute ventilation, the body mass index and the presence of upper respiratory tract infection could be found.
Children with bronchial asthma have significantly higher levels of orally exhaled nitric oxide than healthy controls.</description><subject>Asthma</subject><subject>Asthma - metabolism</subject><subject>Biological and medical sciences</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Breath Tests</subject><subject>Chemiluminescence</subject><subject>Child</subject><subject>Childhood</subject><subject>Children</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medical sciences</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - metabolism</subject><subject>Pneumology</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests</subject><subject>Respiratory tract diseases</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0M1LwzAYBvAgyqzTi3ehoIgI1SRv2yRHHZsKAy96Lmk-aEY_ZtLC_O-trEzw9B7eHw8PD0KXBD8QjNnj8woTkTGS5UcoIinQhGCWH6MIQ4qTnAhxis5C2OARC8JnaMY5CEZ5hO6Wu0rWRset671Tcbdz2sSujVXlal11nY5l6KtGnqMTK-tgLqY7R5-r5cfiNVm_v7wtntaJAhB9IgVWkqYZ00ApSAslt6WiJaXMYMMxyYlNKbO2NEIYyBnVwIUWGDLJOBMwR7f73K3vvgYT-qJxQZm6lq3phlCwsTlAmo3w-h_cdINvx24FESkQkueAR3W_V8p3IXhji613jfTfBcHF73jF33gjvpoih7Ix-kCntcb_zfSXQcnaetkqFw4MSCZoRuEH5iFyvg</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>ARTLICH, A</creator><creator>HAGENAH, J.-U</creator><creator>JONAS, S</creator><creator>AHRENS, P</creator><creator>GORTNER, L</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Exhaled nitric oxide in childhood asthma</title><author>ARTLICH, A ; HAGENAH, J.-U ; JONAS, S ; AHRENS, P ; GORTNER, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-a90ca2457d3223af3b8fbc2b227e0e80161f427ffbe99e3672d389d9035a78793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Asthma</topic><topic>Asthma - metabolism</topic><topic>Biological and medical sciences</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Breath Tests</topic><topic>Chemiluminescence</topic><topic>Child</topic><topic>Childhood</topic><topic>Children</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medical sciences</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - metabolism</topic><topic>Pneumology</topic><topic>Respiratory function</topic><topic>Respiratory Function Tests</topic><topic>Respiratory tract diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARTLICH, A</creatorcontrib><creatorcontrib>HAGENAH, J.-U</creatorcontrib><creatorcontrib>JONAS, S</creatorcontrib><creatorcontrib>AHRENS, P</creatorcontrib><creatorcontrib>GORTNER, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARTLICH, A</au><au>HAGENAH, J.-U</au><au>JONAS, S</au><au>AHRENS, P</au><au>GORTNER, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exhaled nitric oxide in childhood asthma</atitle><jtitle>European journal of pediatrics</jtitle><addtitle>Eur J Pediatr</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>155</volume><issue>8</issue><spage>698</spage><epage>701</epage><pages>698-701</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><coden>EJPEDT</coden><abstract>Endogenous synthesis of nitric oxide (NO) and its presence in exhaled air was observed in various species including humans. Particularly high levels were found in adults with bronchial asthma, possibly because of the underlying pulmonary inflammatory activity. We studied oral and nasal exhaled NO by chemiluminescence in 47 children aged between 6 and 10 years. Thirty children had bronchial asthma, 17 were healthy controls. In asthmatic children oral exhaled NO was 13.4 +/- 1.4 parts per billion (ppb) (mean +/- SEM), nasal exhaled NO was 21.7 +/- 1.5 ppb. In healthy controls oral exhaled NO was 7.2 +/0 1.0 ppb, nasal exhaled NO was 18.2 +/- 22 ppb. Oral exhaled NO was significantly higher in asthmatic children compared to healthy controls (P = 0.0017). Nasal exhaled NO did not differ significantly in the two groups. There was a significant negative correlation between oral exhaled NO and forced expiratory volume in 1 s (FeV1). No significant correlation between oral or nasal exhaled NO and other markers of obstructive lung function impairment, oral minute ventilation, the body mass index and the presence of upper respiratory tract infection could be found.
Children with bronchial asthma have significantly higher levels of orally exhaled nitric oxide than healthy controls.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>8839728</pmid><doi>10.1007/BF01957156</doi><tpages>4</tpages></addata></record> |
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| subjects | Asthma Asthma - metabolism Biological and medical sciences Body mass Body mass index Breath Tests Chemiluminescence Child Childhood Children Chronic obstructive pulmonary disease, asthma Female Humans Inflammation Male Mechanical ventilation Medical sciences Nitric oxide Nitric Oxide - analysis Nitric Oxide - metabolism Pneumology Respiratory function Respiratory Function Tests Respiratory tract diseases |
| title | Exhaled nitric oxide in childhood asthma |
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