Tissue-specific methylation differences and cognitive function in fragile X premutation females

Tissue‐specific variation in (CGG)n repeat size and methylation status of the FMR1 gene was investigated in 17 female premutation carriers. Minor variation in premutation repeat size among leukocyte, lymphoblast, and fibroblast tissues was noted in some subjects. One subject exhibited a premutation...

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Veröffentlicht in:	American journal of medical genetics 1996-08, Vol.64 (2), p.329-333
Hauptverfasser:	Allingham-Hawkins, Diane J., Brown, Charlotte A., Babul, Riyana, Chitayat, David, Krekewich, Karla, Humphries, Tom, Ray, Peter N., Teshima, Ikuko E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Cognition DNA - analysis DNA - blood DNA Methylation Female Fibroblasts FMR1 Fragile X Mental Retardation Protein fragile X syndrome Fragile X Syndrome - genetics Fragile X Syndrome - psychology Heterozygote Humans Intelligence Tests Leukocytes - metabolism Lymphocytes - metabolism methylation Middle Aged Nerve Tissue Proteins - genetics Polymerase Chain Reaction premutation RNA-Binding Proteins Trinucleotide Repeats Wechsler Scales
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