Differential effects of N-methyl- d-aspartic acid and l-homocysteic acid on cerebellar Purkinje neurons
The effects of N-methyl- d-aspartic acid (NMDA) and l-homocysteic acid (LH) were measured on cerebellar Purkinje neurons. In urethane-anesthetized rats, iontophoretic application of NMDA elicited 3 different effects on the spontaneous activity of Purkinje cells: excitation, inhibition and biphasic r...
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| Veröffentlicht in: | Brain research 1988-07, Vol.456 (1), p.104-112 |
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| creator | Lee, Munhyang Strahlendorf, Howard K. Strahlendorf, Jean C. |
| description | The effects of
N-methyl-
d-aspartic acid (NMDA) and
l-homocysteic acid (LH) were measured on cerebellar Purkinje neurons. In urethane-anesthetized rats, iontophoretic application of NMDA elicited 3 different effects on the spontaneous activity of Purkinje cells: excitation, inhibition and biphasic responses consisting of excitation followed by inhibition. On the other hand, LH elicited excitation, only, regardless of the actions of NMDA on the same neurons. We also examined the effects of various excitatory amino acid antagonists on NMDA- and LH-mediated responses. Excitatory effects of NMDA were antagonized effectively by
dl2-amino-5-phosphonovalerate (APV), ketamine, γ-
d-glutamylglycine (DGG),
dl-2-amino-7-phosphonoheptanoate (APH), and were not influenced significantly by
lglutamate diethylester (GDEE). Inhibitory responses of NMDA were antagonized by APV, APH and ketamine. LH-mediated excitations were influenced significantly by DGG and ketamine whereas GDEE, APV and APH failed significantly to attenuate the effects of LH. Based on the differential actions of LH and NMDA and the selectively of NMDA antagonists for NMDA rather than LH-mediated excitations, it appears that the major actionsof LH may not be mediated through NMDA receptor sites, at least in the cerebellum. |
| doi_str_mv | 10.1016/0006-8993(88)90351-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78391789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0006899388903514</els_id><sourcerecordid>15004170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-a12c88df4d6bd19a0526af7b6aa7b9f2bbe8974961201d6624895787a1b56a703</originalsourceid><addsrcrecordid>eNqFUU1vFSEUJUZTn9V_oAkLY-qCCvPBx8bEtFqbNOpC14SBi6XOwCvMmLx_L-N7vmVdAfece3I4B6GXjJ4zyvg7SiknUqn2TMq3irY9I90jtGFSNIQ3HX2MNkfKU_SslLv6bFtFT9BJoyrC-w36eRm8hwxxDmbEUO92Ljh5_IVMMN_uRoIdMWVr8hwsNjY4bKLDI7lNU7K7MsO_cYrYVqEBxtFk_G3Jv0K8AxxhySmW5-iJN2OBF4fzFP349PH7xWdy8_Xq-uLDDbEdEzMxrLFSOt85PjimDO0bbrwYuDFiUL4ZBpBKdIqzhjLH6zel6oUUhg09N4K2p-jNXneb0_0CZdZTKHb1FCEtRQvZKiak-i-R9ZRWS6tityfanErJ4PU2h8nknWZUr0XoNWW9pqyl1H-L0F1de3XQX4YJ3HHpkHzFXx9wU6wZfTbRhnKkCdnIKlRp7_c0qKH9DpB1sQGiBRdyrUq7FB728QeQCaO-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15004170</pqid></control><display><type>article</type><title>Differential effects of N-methyl- d-aspartic acid and l-homocysteic acid on cerebellar Purkinje neurons</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Lee, Munhyang ; Strahlendorf, Howard K. ; Strahlendorf, Jean C.</creator><creatorcontrib>Lee, Munhyang ; Strahlendorf, Howard K. ; Strahlendorf, Jean C.</creatorcontrib><description>The effects of
N-methyl-
d-aspartic acid (NMDA) and
l-homocysteic acid (LH) were measured on cerebellar Purkinje neurons. In urethane-anesthetized rats, iontophoretic application of NMDA elicited 3 different effects on the spontaneous activity of Purkinje cells: excitation, inhibition and biphasic responses consisting of excitation followed by inhibition. On the other hand, LH elicited excitation, only, regardless of the actions of NMDA on the same neurons. We also examined the effects of various excitatory amino acid antagonists on NMDA- and LH-mediated responses. Excitatory effects of NMDA were antagonized effectively by
dl2-amino-5-phosphonovalerate (APV), ketamine, γ-
d-glutamylglycine (DGG),
dl-2-amino-7-phosphonoheptanoate (APH), and were not influenced significantly by
lglutamate diethylester (GDEE). Inhibitory responses of NMDA were antagonized by APV, APH and ketamine. LH-mediated excitations were influenced significantly by DGG and ketamine whereas GDEE, APV and APH failed significantly to attenuate the effects of LH. Based on the differential actions of LH and NMDA and the selectively of NMDA antagonists for NMDA rather than LH-mediated excitations, it appears that the major actionsof LH may not be mediated through NMDA receptor sites, at least in the cerebellum.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(88)90351-4</identifier><identifier>PMID: 2900665</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>2-Amino-5-phosphonovalerate ; Action Potentials - drug effects ; Amino Acids ; Animals ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - pharmacology ; Biological and medical sciences ; Central nervous system ; Dipeptides - pharmacology ; Electrophysiology ; Excitatory amino acid antagonist ; Fundamental and applied biological sciences. Psychology ; Glutamates - pharmacology ; Homocysteine - analogs & derivatives ; Homocysteine - pharmacology ; Iontophoresis ; Ketamine ; l-Homocysteic acid ; Male ; Microiontophoresis ; N-Methyl- d-aspartic acid ; N-Methylaspartate ; Purkinje Cells - drug effects ; Purkinje Cells - physiology ; Purkinje neuron ; Rats ; Rats, Inbred Strains ; Valine - analogs & derivatives ; Valine - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1988-07, Vol.456 (1), p.104-112</ispartof><rights>1988 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-a12c88df4d6bd19a0526af7b6aa7b9f2bbe8974961201d6624895787a1b56a703</citedby><cites>FETCH-LOGICAL-c417t-a12c88df4d6bd19a0526af7b6aa7b9f2bbe8974961201d6624895787a1b56a703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(88)90351-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7828351$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2900665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Munhyang</creatorcontrib><creatorcontrib>Strahlendorf, Howard K.</creatorcontrib><creatorcontrib>Strahlendorf, Jean C.</creatorcontrib><title>Differential effects of N-methyl- d-aspartic acid and l-homocysteic acid on cerebellar Purkinje neurons</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The effects of
N-methyl-
d-aspartic acid (NMDA) and
l-homocysteic acid (LH) were measured on cerebellar Purkinje neurons. In urethane-anesthetized rats, iontophoretic application of NMDA elicited 3 different effects on the spontaneous activity of Purkinje cells: excitation, inhibition and biphasic responses consisting of excitation followed by inhibition. On the other hand, LH elicited excitation, only, regardless of the actions of NMDA on the same neurons. We also examined the effects of various excitatory amino acid antagonists on NMDA- and LH-mediated responses. Excitatory effects of NMDA were antagonized effectively by
dl2-amino-5-phosphonovalerate (APV), ketamine, γ-
d-glutamylglycine (DGG),
dl-2-amino-7-phosphonoheptanoate (APH), and were not influenced significantly by
lglutamate diethylester (GDEE). Inhibitory responses of NMDA were antagonized by APV, APH and ketamine. LH-mediated excitations were influenced significantly by DGG and ketamine whereas GDEE, APV and APH failed significantly to attenuate the effects of LH. Based on the differential actions of LH and NMDA and the selectively of NMDA antagonists for NMDA rather than LH-mediated excitations, it appears that the major actionsof LH may not be mediated through NMDA receptor sites, at least in the cerebellum.</description><subject>2-Amino-5-phosphonovalerate</subject><subject>Action Potentials - drug effects</subject><subject>Amino Acids</subject><subject>Animals</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Dipeptides - pharmacology</subject><subject>Electrophysiology</subject><subject>Excitatory amino acid antagonist</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamates - pharmacology</subject><subject>Homocysteine - analogs & derivatives</subject><subject>Homocysteine - pharmacology</subject><subject>Iontophoresis</subject><subject>Ketamine</subject><subject>l-Homocysteic acid</subject><subject>Male</subject><subject>Microiontophoresis</subject><subject>N-Methyl- d-aspartic acid</subject><subject>N-Methylaspartate</subject><subject>Purkinje Cells - drug effects</subject><subject>Purkinje Cells - physiology</subject><subject>Purkinje neuron</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Valine - analogs & derivatives</subject><subject>Valine - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1vFSEUJUZTn9V_oAkLY-qCCvPBx8bEtFqbNOpC14SBi6XOwCvMmLx_L-N7vmVdAfece3I4B6GXjJ4zyvg7SiknUqn2TMq3irY9I90jtGFSNIQ3HX2MNkfKU_SslLv6bFtFT9BJoyrC-w36eRm8hwxxDmbEUO92Ljh5_IVMMN_uRoIdMWVr8hwsNjY4bKLDI7lNU7K7MsO_cYrYVqEBxtFk_G3Jv0K8AxxhySmW5-iJN2OBF4fzFP349PH7xWdy8_Xq-uLDDbEdEzMxrLFSOt85PjimDO0bbrwYuDFiUL4ZBpBKdIqzhjLH6zel6oUUhg09N4K2p-jNXneb0_0CZdZTKHb1FCEtRQvZKiak-i-R9ZRWS6tityfanErJ4PU2h8nknWZUr0XoNWW9pqyl1H-L0F1de3XQX4YJ3HHpkHzFXx9wU6wZfTbRhnKkCdnIKlRp7_c0qKH9DpB1sQGiBRdyrUq7FB728QeQCaO-</recordid><startdate>19880719</startdate><enddate>19880719</enddate><creator>Lee, Munhyang</creator><creator>Strahlendorf, Howard K.</creator><creator>Strahlendorf, Jean C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880719</creationdate><title>Differential effects of N-methyl- d-aspartic acid and l-homocysteic acid on cerebellar Purkinje neurons</title><author>Lee, Munhyang ; Strahlendorf, Howard K. ; Strahlendorf, Jean C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-a12c88df4d6bd19a0526af7b6aa7b9f2bbe8974961201d6624895787a1b56a703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>2-Amino-5-phosphonovalerate</topic><topic>Action Potentials - drug effects</topic><topic>Amino Acids</topic><topic>Animals</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Dipeptides - pharmacology</topic><topic>Electrophysiology</topic><topic>Excitatory amino acid antagonist</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamates - pharmacology</topic><topic>Homocysteine - analogs & derivatives</topic><topic>Homocysteine - pharmacology</topic><topic>Iontophoresis</topic><topic>Ketamine</topic><topic>l-Homocysteic acid</topic><topic>Male</topic><topic>Microiontophoresis</topic><topic>N-Methyl- d-aspartic acid</topic><topic>N-Methylaspartate</topic><topic>Purkinje Cells - drug effects</topic><topic>Purkinje Cells - physiology</topic><topic>Purkinje neuron</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Valine - analogs & derivatives</topic><topic>Valine - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Munhyang</creatorcontrib><creatorcontrib>Strahlendorf, Howard K.</creatorcontrib><creatorcontrib>Strahlendorf, Jean C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Munhyang</au><au>Strahlendorf, Howard K.</au><au>Strahlendorf, Jean C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential effects of N-methyl- d-aspartic acid and l-homocysteic acid on cerebellar Purkinje neurons</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1988-07-19</date><risdate>1988</risdate><volume>456</volume><issue>1</issue><spage>104</spage><epage>112</epage><pages>104-112</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The effects of
N-methyl-
d-aspartic acid (NMDA) and
l-homocysteic acid (LH) were measured on cerebellar Purkinje neurons. In urethane-anesthetized rats, iontophoretic application of NMDA elicited 3 different effects on the spontaneous activity of Purkinje cells: excitation, inhibition and biphasic responses consisting of excitation followed by inhibition. On the other hand, LH elicited excitation, only, regardless of the actions of NMDA on the same neurons. We also examined the effects of various excitatory amino acid antagonists on NMDA- and LH-mediated responses. Excitatory effects of NMDA were antagonized effectively by
dl2-amino-5-phosphonovalerate (APV), ketamine, γ-
d-glutamylglycine (DGG),
dl-2-amino-7-phosphonoheptanoate (APH), and were not influenced significantly by
lglutamate diethylester (GDEE). Inhibitory responses of NMDA were antagonized by APV, APH and ketamine. LH-mediated excitations were influenced significantly by DGG and ketamine whereas GDEE, APV and APH failed significantly to attenuate the effects of LH. Based on the differential actions of LH and NMDA and the selectively of NMDA antagonists for NMDA rather than LH-mediated excitations, it appears that the major actionsof LH may not be mediated through NMDA receptor sites, at least in the cerebellum.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2900665</pmid><doi>10.1016/0006-8993(88)90351-4</doi><tpages>9</tpages></addata></record> |
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| ispartof | Brain research, 1988-07, Vol.456 (1), p.104-112 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 2-Amino-5-phosphonovalerate Action Potentials - drug effects Amino Acids Animals Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Biological and medical sciences Central nervous system Dipeptides - pharmacology Electrophysiology Excitatory amino acid antagonist Fundamental and applied biological sciences. Psychology Glutamates - pharmacology Homocysteine - analogs & derivatives Homocysteine - pharmacology Iontophoresis Ketamine l-Homocysteic acid Male Microiontophoresis N-Methyl- d-aspartic acid N-Methylaspartate Purkinje Cells - drug effects Purkinje Cells - physiology Purkinje neuron Rats Rats, Inbred Strains Valine - analogs & derivatives Valine - pharmacology Vertebrates: nervous system and sense organs |
| title | Differential effects of N-methyl- d-aspartic acid and l-homocysteic acid on cerebellar Purkinje neurons |
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