AP-1 regulation of the rat bone sialoprotein gene transcription is mediated through a TPA response element within a glucocorticoid response unit in the gene promoter

Bone sialoprotein (BSP), a protein which has been implicated in the initial mineralization of newly-formed bone, provides an early phenotypic marker for differentiated osteoblasts. BSP expression is induced by glucocorticoids in association with osteoblast differentiation, and a glucocorticoid respo...

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Veröffentlicht in:	Matrix biology 1996-07, Vol.15 (2), p.119-130
Hauptverfasser:	Yamauchi, Masato, Ogata, Yorimasa, Kim, Richard H., Li, Jack J., Freedman, Leonard P., Sodek, Jaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AP-1 bone Bone and Bones - metabolism bone sialoprotein Female fos gene regulation Genes, fos Genes, jun glucocorticoids Glucocorticoids - genetics Glucocorticoids - metabolism Integrin-Binding Sialoprotein jun mineralized tissues phorbol esters Pregnancy Promoter Regions, Genetic - genetics Rats Sialoglycoproteins - genetics Space life sciences transcription Transcription Factor AP-1 - genetics Transcriptional Activation
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