A novel enzyme system for the reduction of 3-oxo bile acids in human red blood cells

7α,12α-Dihydroxy-3-oxo- and 3,7,12-trioxo-5β-cholanoic acids labeled with 18O atoms were incubated with human red blood cells, and the biotransformation products were separated and characterized by gas chromatography-mass spectrometry as the pentafluorobenzyl ester-trimethylsilyl and -dimethylethyls...

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Veröffentlicht in:	Steroids 1996-07, Vol.61 (7), p.416-420
Hauptverfasser:	Goto, Junichi, Miura, Hiroya, Ando, Masayuki, Yamato, Yasuhiro, Ikegawa, Shigeo, Nambara, Toshio, Makino, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	3-oxo bile acid Bile Acids and Salts - chemistry Bile Acids and Salts - metabolism Biological and medical sciences Biotransformation Blood - metabolism Cholic Acids - chemical synthesis Cholic Acids - chemistry Cholic Acids - metabolism Chromatography, Gas Dehydrocholic Acid - chemical synthesis Dehydrocholic Acid - chemistry Dehydrocholic Acid - metabolism enzymic reduction Erythrocytes - metabolism extrahepatic biotransformation Fundamental and applied biological sciences. Psychology gas chromatography-mass spectrometry Humans ion cluster technique Mass Spectrometry Molecular Structure Oxidation-Reduction Oxygen Isotopes red blood cell Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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