A molecular perspective of the genetic relationships of G-protein coupled melatonin receptor subtypes

: Successful cloning of melatonin receptors from various target tissues in the past few years has increased our understanding of the molecular signal transduction mechanisms of G‐protein coupled melatonin receptors, of which three subtypes (MEL‐1A, MEL‐1B, and MEL‐1C) have been reported in different...

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Veröffentlicht in:Journal of pineal research 1996-05, Vol.20 (4), p.198-204
Hauptverfasser: Shiu, S.Y.W., Ng, N., Pang, S.F.
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container_title Journal of pineal research
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creator Shiu, S.Y.W.
Ng, N.
Pang, S.F.
description : Successful cloning of melatonin receptors from various target tissues in the past few years has increased our understanding of the molecular signal transduction mechanisms of G‐protein coupled melatonin receptors, of which three subtypes (MEL‐1A, MEL‐1B, and MEL‐1C) have been reported in different vertebrates. Based upon melatonin receptor sequences available in the Genbank database, we have performed phylogenetic analyses of the nucleotide and encoded amino acid sequences of G‐protein‐coupled melatonin receptors, and determined the range of amino acid identities between melatonin receptors of the same and different subtypes. Besides the three well‐known subtypes, a potential novel subtype of MEL‐1D, as exemplified by unique separation of Xenopus X2.0 sequence (Genbank accession No. U31826) from the others in the protein phylogenetic tree, possibly exists. In addition, one of the chicken brain melatonin receptor sequences has been identified as belonging to the MEL‐1B subtype. Our analyses showed that melatonin receptors of the same subtype and different subtypes are likely to share >75% and
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Based upon melatonin receptor sequences available in the Genbank database, we have performed phylogenetic analyses of the nucleotide and encoded amino acid sequences of G‐protein‐coupled melatonin receptors, and determined the range of amino acid identities between melatonin receptors of the same and different subtypes. Besides the three well‐known subtypes, a potential novel subtype of MEL‐1D, as exemplified by unique separation of Xenopus X2.0 sequence (Genbank accession No. U31826) from the others in the protein phylogenetic tree, possibly exists. In addition, one of the chicken brain melatonin receptor sequences has been identified as belonging to the MEL‐1B subtype. Our analyses showed that melatonin receptors of the same subtype and different subtypes are likely to share &gt;75% and &lt;65% amino acid identities, respectively. Phylogenetic analysis based on amino acid comparisons will be needed to determine the subtype status of any pair of melatonin receptor sequences that exhibit ≥65% to &lt;75% amino acid identity. Despite the usefulness of genetic relatedness in the subtype classification of G‐protein‐coupled melatonin receptors, functional correlation of molecular structure may ultimately prove the most comprehensive approach in melatonin receptor classification.</description><identifier>ISSN: 0742-3098</identifier><identifier>EISSN: 1600-079X</identifier><identifier>DOI: 10.1111/j.1600-079X.1996.tb00259.x</identifier><identifier>PMID: 8836953</identifier><identifier>CODEN: JPRSE9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>amino acid homology ; Amino Acid Sequence ; Animals ; Biological and medical sciences ; Cell receptors ; Cell structures and functions ; chicken -Xenopus ; Fundamental and applied biological sciences. 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Based upon melatonin receptor sequences available in the Genbank database, we have performed phylogenetic analyses of the nucleotide and encoded amino acid sequences of G‐protein‐coupled melatonin receptors, and determined the range of amino acid identities between melatonin receptors of the same and different subtypes. Besides the three well‐known subtypes, a potential novel subtype of MEL‐1D, as exemplified by unique separation of Xenopus X2.0 sequence (Genbank accession No. U31826) from the others in the protein phylogenetic tree, possibly exists. In addition, one of the chicken brain melatonin receptor sequences has been identified as belonging to the MEL‐1B subtype. Our analyses showed that melatonin receptors of the same subtype and different subtypes are likely to share &gt;75% and &lt;65% amino acid identities, respectively. Phylogenetic analysis based on amino acid comparisons will be needed to determine the subtype status of any pair of melatonin receptor sequences that exhibit ≥65% to &lt;75% amino acid identity. Despite the usefulness of genetic relatedness in the subtype classification of G‐protein‐coupled melatonin receptors, functional correlation of molecular structure may ultimately prove the most comprehensive approach in melatonin receptor classification.</description><subject>amino acid homology</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>chicken -Xenopus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GTP-Binding Proteins - genetics</subject><subject>Hormone receptors. Growth factor receptors. Cytokine receptors. 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Psychology</topic><topic>GTP-Binding Proteins - genetics</topic><topic>Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors</topic><topic>human</topic><topic>Humans</topic><topic>Melatonin</topic><topic>melatonin receptor</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>phylogenetic analysis</topic><topic>Phylogeny</topic><topic>Receptors, Cell Surface - classification</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cytoplasmic and Nuclear - classification</topic><topic>Receptors, Cytoplasmic and Nuclear - genetics</topic><topic>Receptors, Melatonin - classification</topic><topic>Receptors, Melatonin - genetics</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><topic>Xenopus Proteins - classification</topic><topic>Xenopus Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiu, S.Y.W.</creatorcontrib><creatorcontrib>Ng, N.</creatorcontrib><creatorcontrib>Pang, S.F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pineal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiu, S.Y.W.</au><au>Ng, N.</au><au>Pang, S.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A molecular perspective of the genetic relationships of G-protein coupled melatonin receptor subtypes</atitle><jtitle>Journal of pineal research</jtitle><addtitle>J Pineal Res</addtitle><date>1996-05</date><risdate>1996</risdate><volume>20</volume><issue>4</issue><spage>198</spage><epage>204</epage><pages>198-204</pages><issn>0742-3098</issn><eissn>1600-079X</eissn><coden>JPRSE9</coden><abstract>: Successful cloning of melatonin receptors from various target tissues in the past few years has increased our understanding of the molecular signal transduction mechanisms of G‐protein coupled melatonin receptors, of which three subtypes (MEL‐1A, MEL‐1B, and MEL‐1C) have been reported in different vertebrates. Based upon melatonin receptor sequences available in the Genbank database, we have performed phylogenetic analyses of the nucleotide and encoded amino acid sequences of G‐protein‐coupled melatonin receptors, and determined the range of amino acid identities between melatonin receptors of the same and different subtypes. Besides the three well‐known subtypes, a potential novel subtype of MEL‐1D, as exemplified by unique separation of Xenopus X2.0 sequence (Genbank accession No. U31826) from the others in the protein phylogenetic tree, possibly exists. In addition, one of the chicken brain melatonin receptor sequences has been identified as belonging to the MEL‐1B subtype. Our analyses showed that melatonin receptors of the same subtype and different subtypes are likely to share &gt;75% and &lt;65% amino acid identities, respectively. Phylogenetic analysis based on amino acid comparisons will be needed to determine the subtype status of any pair of melatonin receptor sequences that exhibit ≥65% to &lt;75% amino acid identity. Despite the usefulness of genetic relatedness in the subtype classification of G‐protein‐coupled melatonin receptors, functional correlation of molecular structure may ultimately prove the most comprehensive approach in melatonin receptor classification.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8836953</pmid><doi>10.1111/j.1600-079X.1996.tb00259.x</doi><tpages>7</tpages></addata></record>
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language eng
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source Wiley Online Library - AutoHoldings Journals; MEDLINE
subjects amino acid homology
Amino Acid Sequence
Animals
Biological and medical sciences
Cell receptors
Cell structures and functions
chicken -Xenopus
Fundamental and applied biological sciences. Psychology
GTP-Binding Proteins - genetics
Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors
human
Humans
Melatonin
melatonin receptor
Molecular and cellular biology
Molecular Sequence Data
phylogenetic analysis
Phylogeny
Receptors, Cell Surface - classification
Receptors, Cell Surface - genetics
Receptors, Cytoplasmic and Nuclear - classification
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Melatonin - classification
Receptors, Melatonin - genetics
Sequence Alignment
Sequence Homology, Amino Acid
Xenopus Proteins - classification
Xenopus Proteins - genetics
title A molecular perspective of the genetic relationships of G-protein coupled melatonin receptor subtypes
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