INTERACTION OF A NEW DEPOLYMERIZED HOLOTHURIAN GLYCOSAMINOGLYCAN WITH PROTEINS IN HUMAN PLASMA

In a rat template bleeding model, depolymerized holothurian glycosaminoglycan (DHG) prolonged bleeding time at 30 mg/kg i.v. but unfractionated heparin (UFH) had the same effect at 1 mg/kg i.v., indicating that DHG is much less bleeding than UFH. To characterize this difference, we examined the affi...

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Veröffentlicht in:	Thrombosis research 1996-08, Vol.83 (3), p.253-264
Hauptverfasser:	Minamiguchi, Kazuhisa, Nagase, Hideki, Kitazato, Keiko T, Kitazato, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticoagulant Bleeding Time Blood Proteins - metabolism depolymerized holothurian glycosaminoglycan glycosaminoglycan Glycosaminoglycans - metabolism Glycosaminoglycans - pharmacology Hemorrhage - metabolism Humans Protein Binding Rats
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