Corticosteroid and immune responses to cardiac surgery
Serum corticosteroid-binding globulin (CBG) and cortisol levels as well as subsets of circulating immunocompetent cells (ICCs) were measured during cardiac surgery. Closed heart surgery (closed mitral commissurotomy) resulted in an elevation of cortisol levels (up to 32 ± 5 μg/dL by the end of the s...
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| Veröffentlicht in: | Steroids 1996-07, Vol.61 (7), p.411-415 |
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| creator | Tinnikov, Alexander A. Legan, Marina V. Sheveluk, Natalya A. Cvetovskaya, Galina A. Naumenko, Sergei E. Sidelnikov, Sergei G. |
| description | Serum corticosteroid-binding globulin (CBG) and cortisol levels as well as subsets of circulating immunocompetent cells (ICCs) were measured during cardiac surgery. Closed heart surgery (closed mitral commissurotomy) resulted in an elevation of cortisol levels (up to 32 ± 5 μg/dL by the end of the surgery) with no changes in CBG and ICC levels observed. Open heart surgery (open reconstruction of the mitral valve) in surface-induced hypothermia (without extracorporeal bypass) caused a dramatic drop in CBG activity (from 250 ± 17 μM before the beginning of anesthesia to 198 ± 15 μM by the end of cooling (just before cardiac arrest) and 158 ± 13 μM after 30 min of reperfusion), whereas cortisol levels were only slightly elevated by the end of cooling, and a significant increase (up to 17 ± 2 μg/dL) was observed only at the end of the surgery (60 min of reperfusion and warming). Similar to CBG, a significant decline in circulating ICC contents occurred in response to cooling and circulatory arrest. |
| doi_str_mv | 10.1016/0039-128X(96)00060-8 |
| format | Article |
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Closed heart surgery (closed mitral commissurotomy) resulted in an elevation of cortisol levels (up to 32 ± 5 μg/dL by the end of the surgery) with no changes in CBG and ICC levels observed. Open heart surgery (open reconstruction of the mitral valve) in surface-induced hypothermia (without extracorporeal bypass) caused a dramatic drop in CBG activity (from 250 ± 17 μM before the beginning of anesthesia to 198 ± 15 μM by the end of cooling (just before cardiac arrest) and 158 ± 13 μM after 30 min of reperfusion), whereas cortisol levels were only slightly elevated by the end of cooling, and a significant increase (up to 17 ± 2 μg/dL) was observed only at the end of the surgery (60 min of reperfusion and warming). 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Closed heart surgery (closed mitral commissurotomy) resulted in an elevation of cortisol levels (up to 32 ± 5 μg/dL by the end of the surgery) with no changes in CBG and ICC levels observed. Open heart surgery (open reconstruction of the mitral valve) in surface-induced hypothermia (without extracorporeal bypass) caused a dramatic drop in CBG activity (from 250 ± 17 μM before the beginning of anesthesia to 198 ± 15 μM by the end of cooling (just before cardiac arrest) and 158 ± 13 μM after 30 min of reperfusion), whereas cortisol levels were only slightly elevated by the end of cooling, and a significant increase (up to 17 ± 2 μg/dL) was observed only at the end of the surgery (60 min of reperfusion and warming). Similar to CBG, a significant decline in circulating ICC contents occurred in response to cooling and circulatory arrest.</description><subject>Adrenal Cortex Hormones - blood</subject><subject>Adult</subject><subject>B-Lymphocytes - immunology</subject><subject>cardiac arrest</subject><subject>Cardiac Surgical Procedures</subject><subject>corticosteroid-binding globulin</subject><subject>Extracorporeal Circulation</subject><subject>Female</subject><subject>Heart Arrest, Induced</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>hypothermia</subject><subject>Hypothermia, Induced</subject><subject>Immunity</subject><subject>immunocompetent cells</subject><subject>Male</subject><subject>Mitral Valve - surgery</subject><subject>Mitral Valve Stenosis - blood</subject><subject>Mitral Valve Stenosis - immunology</subject><subject>Mitral Valve Stenosis - surgery</subject><subject>stress</subject><subject>T-Lymphocytes - immunology</subject><subject>Transcortin - analysis</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotVa_gcKeRA-rk6TZJBdBiv-g4EXBW0iTWYl0NzXZFfrt3aXFo6dhmPfezPwIOadwQ4FWtwBcl5SpjytdXQNABaU6IFOqpCqFquQhmf5JjslJzl-jiGs2IROluGSaT0m1iKkLLuYOUwy-sK0vQtP0LRYJ8ya2GXPRxcLZ5IN1Re7TJ6btKTmq7Trj2b7OyPvjw9viuVy-Pr0s7pel40J2pV4pDUqjpiBAgvVKSKDgKZvbynpRrewcNLWMCSrYSiHlfjix1qK2nKmaz8jlLneT4nePuTNNyA7Xa9ti7LORiitBpR6E853QpZhzwtpsUmhs2hoKZsRlRhZmZGH02Ay4jBpsF_v8ftWg_zPt-Qzzu90chyd_AiaTXcDWoQ8JXWd8DP8v-AUfCXhc</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Tinnikov, Alexander A.</creator><creator>Legan, Marina V.</creator><creator>Sheveluk, Natalya A.</creator><creator>Cvetovskaya, Galina A.</creator><creator>Naumenko, Sergei E.</creator><creator>Sidelnikov, Sergei G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Corticosteroid and immune responses to cardiac surgery</title><author>Tinnikov, Alexander A. ; Legan, Marina V. ; Sheveluk, Natalya A. ; Cvetovskaya, Galina A. ; Naumenko, Sergei E. ; Sidelnikov, Sergei G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-9b89089e9105070ad857010d124a6ad56ba4091a225152b8e13d063f95fa328f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenal Cortex Hormones - blood</topic><topic>Adult</topic><topic>B-Lymphocytes - immunology</topic><topic>cardiac arrest</topic><topic>Cardiac Surgical Procedures</topic><topic>corticosteroid-binding globulin</topic><topic>Extracorporeal Circulation</topic><topic>Female</topic><topic>Heart Arrest, Induced</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>hypothermia</topic><topic>Hypothermia, Induced</topic><topic>Immunity</topic><topic>immunocompetent cells</topic><topic>Male</topic><topic>Mitral Valve - surgery</topic><topic>Mitral Valve Stenosis - blood</topic><topic>Mitral Valve Stenosis - immunology</topic><topic>Mitral Valve Stenosis - surgery</topic><topic>stress</topic><topic>T-Lymphocytes - immunology</topic><topic>Transcortin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tinnikov, Alexander A.</creatorcontrib><creatorcontrib>Legan, Marina V.</creatorcontrib><creatorcontrib>Sheveluk, Natalya A.</creatorcontrib><creatorcontrib>Cvetovskaya, Galina A.</creatorcontrib><creatorcontrib>Naumenko, Sergei E.</creatorcontrib><creatorcontrib>Sidelnikov, Sergei G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tinnikov, Alexander A.</au><au>Legan, Marina V.</au><au>Sheveluk, Natalya A.</au><au>Cvetovskaya, Galina A.</au><au>Naumenko, Sergei E.</au><au>Sidelnikov, Sergei G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corticosteroid and immune responses to cardiac surgery</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>61</volume><issue>7</issue><spage>411</spage><epage>415</epage><pages>411-415</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><abstract>Serum corticosteroid-binding globulin (CBG) and cortisol levels as well as subsets of circulating immunocompetent cells (ICCs) were measured during cardiac surgery. Closed heart surgery (closed mitral commissurotomy) resulted in an elevation of cortisol levels (up to 32 ± 5 μg/dL by the end of the surgery) with no changes in CBG and ICC levels observed. Open heart surgery (open reconstruction of the mitral valve) in surface-induced hypothermia (without extracorporeal bypass) caused a dramatic drop in CBG activity (from 250 ± 17 μM before the beginning of anesthesia to 198 ± 15 μM by the end of cooling (just before cardiac arrest) and 158 ± 13 μM after 30 min of reperfusion), whereas cortisol levels were only slightly elevated by the end of cooling, and a significant increase (up to 17 ± 2 μg/dL) was observed only at the end of the surgery (60 min of reperfusion and warming). Similar to CBG, a significant decline in circulating ICC contents occurred in response to cooling and circulatory arrest.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8837293</pmid><doi>10.1016/0039-128X(96)00060-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Steroids, 1996-07, Vol.61 (7), p.411-415 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenal Cortex Hormones - blood Adult B-Lymphocytes - immunology cardiac arrest Cardiac Surgical Procedures corticosteroid-binding globulin Extracorporeal Circulation Female Heart Arrest, Induced Hemoglobins - analysis Humans Hydrocortisone - blood hypothermia Hypothermia, Induced Immunity immunocompetent cells Male Mitral Valve - surgery Mitral Valve Stenosis - blood Mitral Valve Stenosis - immunology Mitral Valve Stenosis - surgery stress T-Lymphocytes - immunology Transcortin - analysis |
| title | Corticosteroid and immune responses to cardiac surgery |
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