A comparison of the development of antibody responses to the polysaccharide antigen (Candida albicans mannan) in atopic and healthy infants and children
Summary Background Defeetive antibody response againsl bacterial polysaccharide antigens is known to be associated with recurrent pyogenic infectiotis. The role of childhood allergy as a risk factor for repeated infections with capsulated micro‐organisms has been controversial. Objective To compare...
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| Veröffentlicht in: | Clinical and experimental allergy 1996-02, Vol.26 (2), p.164-170 |
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| container_title | Clinical and experimental allergy |
| container_volume | 26 |
| creator | NERMES, M. FÅLTH-MAGNUSSON, K. SAVOLAINEN, J. VIANDER, M. BJÖRKSTEN, B. |
| description | Summary
Background
Defeetive antibody response againsl bacterial polysaccharide antigens is known to be associated with recurrent pyogenic infectiotis. The role of childhood allergy as a risk factor for repeated infections with capsulated micro‐organisms has been controversial.
Objective
To compare the devetopment of polysaccharide specific antibody responses in atopic and healthy infants and children.
Methods
The antibody responses against a common polysaccharide antigen, Candida albicans mannan, were studied longitudinally in 18 atopic and 19 non‐atopic children over the first 5 years of life. Determinations of IgA, IgG and IgM antibodies were carried out by enzyme‐linked immunosorbent assay and IgE antibodies by nitrocellulose‐based radioallergosorbent test.
Results
The polysaccharide specific antibody responses were similar in both groups, except that anti‐mannan IgM levels were higher at 5 years in the atopic children (P |
| doi_str_mv | 10.1111/j.1365-2222.1996.tb00075.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78384803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78384803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4674-1aa6bbc99b13a670d245f5c4edcacf9b743890302bb780d39ba6bd33e3b3551b3</originalsourceid><addsrcrecordid>eNqVkV-LEzEUxYMoa61-BCGIiD5MTZqZyWQfhFJ2q7Aowoq-hZs_Y1NnknEy1c438eOaaUtfxfsSuOd3zg0chF5QsqBp3u4WlJVFtkyzoEKUi0ERQnixODxAs4v0EM2IKPKMVyJ_jJ7EuEsQK0R1ha6qihV0yWbozwrr0HbQuxg8DjUethYb-8s2oWutH6YV-MGpYEbc29gFH23EQziCXWjGCFpvk9_YI_jdevx6Dd44Axga5TT4iFvwHvwb7DyGIXROJ9bgrYVm2I5pWydrPO701jWmt_4pelRDE-2z8ztHX25v7tfvs7tPmw_r1V2m85LnGQUoldJCKMqg5MQs86IudG6NBl0LxXNWCcLIUileEcOESrxhzDLFioIqNkevTrldH37ubRxk66K2TQPehn2UvGJVXhH2T5ByUpXTrTm6PoG6DzH2tpZd71roR0mJnPqTOzmVJKeS5NSfPPcnD8n8_Hxlr1prLtZzYUl_edYhamjqHrx28YItBec5LxL27oT9do0d_-MDcn2zomWeArJTgIuDPVwCoP8hS84S-fXjRt7nZPNtfftZbthfTqnJPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17086890</pqid></control><display><type>article</type><title>A comparison of the development of antibody responses to the polysaccharide antigen (Candida albicans mannan) in atopic and healthy infants and children</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>NERMES, M. ; FÅLTH-MAGNUSSON, K. ; SAVOLAINEN, J. ; VIANDER, M. ; BJÖRKSTEN, B.</creator><creatorcontrib>NERMES, M. ; FÅLTH-MAGNUSSON, K. ; SAVOLAINEN, J. ; VIANDER, M. ; BJÖRKSTEN, B.</creatorcontrib><description>Summary
Background
Defeetive antibody response againsl bacterial polysaccharide antigens is known to be associated with recurrent pyogenic infectiotis. The role of childhood allergy as a risk factor for repeated infections with capsulated micro‐organisms has been controversial.
Objective
To compare the devetopment of polysaccharide specific antibody responses in atopic and healthy infants and children.
Methods
The antibody responses against a common polysaccharide antigen, Candida albicans mannan, were studied longitudinally in 18 atopic and 19 non‐atopic children over the first 5 years of life. Determinations of IgA, IgG and IgM antibodies were carried out by enzyme‐linked immunosorbent assay and IgE antibodies by nitrocellulose‐based radioallergosorbent test.
Results
The polysaccharide specific antibody responses were similar in both groups, except that anti‐mannan IgM levels were higher at 5 years in the atopic children (P<0.05. student's t‐test).
Conclusion
Atopic children are not more susceptible to bacterial infections on the basis of poorer ability to produce antibodies against polysaccharide antigens.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.1996.tb00075.x</identifier><identifier>PMID: 8835123</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Allergic diseases ; Antibody Formation ; Antigens - immunology ; atopy ; Biological and medical sciences ; Candida albicans ; Candida albicans - immunology ; Child, Preschool ; children ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Hypersensitivity, Immediate - immunology ; Immunoglobulins - analysis ; Immunopathology ; Infant ; infants ; Male ; mannan ; Mannans - immunology ; Medical sciences ; Other localizations ; polysaccharide antigen ; Radioallergosorbent Test</subject><ispartof>Clinical and experimental allergy, 1996-02, Vol.26 (2), p.164-170</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4674-1aa6bbc99b13a670d245f5c4edcacf9b743890302bb780d39ba6bd33e3b3551b3</citedby><cites>FETCH-LOGICAL-c4674-1aa6bbc99b13a670d245f5c4edcacf9b743890302bb780d39ba6bd33e3b3551b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.1996.tb00075.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.1996.tb00075.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2977475$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8835123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NERMES, M.</creatorcontrib><creatorcontrib>FÅLTH-MAGNUSSON, K.</creatorcontrib><creatorcontrib>SAVOLAINEN, J.</creatorcontrib><creatorcontrib>VIANDER, M.</creatorcontrib><creatorcontrib>BJÖRKSTEN, B.</creatorcontrib><title>A comparison of the development of antibody responses to the polysaccharide antigen (Candida albicans mannan) in atopic and healthy infants and children</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Background
Defeetive antibody response againsl bacterial polysaccharide antigens is known to be associated with recurrent pyogenic infectiotis. The role of childhood allergy as a risk factor for repeated infections with capsulated micro‐organisms has been controversial.
Objective
To compare the devetopment of polysaccharide specific antibody responses in atopic and healthy infants and children.
Methods
The antibody responses against a common polysaccharide antigen, Candida albicans mannan, were studied longitudinally in 18 atopic and 19 non‐atopic children over the first 5 years of life. Determinations of IgA, IgG and IgM antibodies were carried out by enzyme‐linked immunosorbent assay and IgE antibodies by nitrocellulose‐based radioallergosorbent test.
Results
The polysaccharide specific antibody responses were similar in both groups, except that anti‐mannan IgM levels were higher at 5 years in the atopic children (P<0.05. student's t‐test).
Conclusion
Atopic children are not more susceptible to bacterial infections on the basis of poorer ability to produce antibodies against polysaccharide antigens.</description><subject>Age Factors</subject><subject>Allergic diseases</subject><subject>Antibody Formation</subject><subject>Antigens - immunology</subject><subject>atopy</subject><subject>Biological and medical sciences</subject><subject>Candida albicans</subject><subject>Candida albicans - immunology</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunoglobulins - analysis</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>infants</subject><subject>Male</subject><subject>mannan</subject><subject>Mannans - immunology</subject><subject>Medical sciences</subject><subject>Other localizations</subject><subject>polysaccharide antigen</subject><subject>Radioallergosorbent Test</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV-LEzEUxYMoa61-BCGIiD5MTZqZyWQfhFJ2q7Aowoq-hZs_Y1NnknEy1c438eOaaUtfxfsSuOd3zg0chF5QsqBp3u4WlJVFtkyzoEKUi0ERQnixODxAs4v0EM2IKPKMVyJ_jJ7EuEsQK0R1ha6qihV0yWbozwrr0HbQuxg8DjUethYb-8s2oWutH6YV-MGpYEbc29gFH23EQziCXWjGCFpvk9_YI_jdevx6Dd44Axga5TT4iFvwHvwb7DyGIXROJ9bgrYVm2I5pWydrPO701jWmt_4pelRDE-2z8ztHX25v7tfvs7tPmw_r1V2m85LnGQUoldJCKMqg5MQs86IudG6NBl0LxXNWCcLIUileEcOESrxhzDLFioIqNkevTrldH37ubRxk66K2TQPehn2UvGJVXhH2T5ByUpXTrTm6PoG6DzH2tpZd71roR0mJnPqTOzmVJKeS5NSfPPcnD8n8_Hxlr1prLtZzYUl_edYhamjqHrx28YItBec5LxL27oT9do0d_-MDcn2zomWeArJTgIuDPVwCoP8hS84S-fXjRt7nZPNtfftZbthfTqnJPw</recordid><startdate>199602</startdate><enddate>199602</enddate><creator>NERMES, M.</creator><creator>FÅLTH-MAGNUSSON, K.</creator><creator>SAVOLAINEN, J.</creator><creator>VIANDER, M.</creator><creator>BJÖRKSTEN, B.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>199602</creationdate><title>A comparison of the development of antibody responses to the polysaccharide antigen (Candida albicans mannan) in atopic and healthy infants and children</title><author>NERMES, M. ; FÅLTH-MAGNUSSON, K. ; SAVOLAINEN, J. ; VIANDER, M. ; BJÖRKSTEN, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4674-1aa6bbc99b13a670d245f5c4edcacf9b743890302bb780d39ba6bd33e3b3551b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Age Factors</topic><topic>Allergic diseases</topic><topic>Antibody Formation</topic><topic>Antigens - immunology</topic><topic>atopy</topic><topic>Biological and medical sciences</topic><topic>Candida albicans</topic><topic>Candida albicans - immunology</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunoglobulins - analysis</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>infants</topic><topic>Male</topic><topic>mannan</topic><topic>Mannans - immunology</topic><topic>Medical sciences</topic><topic>Other localizations</topic><topic>polysaccharide antigen</topic><topic>Radioallergosorbent Test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NERMES, M.</creatorcontrib><creatorcontrib>FÅLTH-MAGNUSSON, K.</creatorcontrib><creatorcontrib>SAVOLAINEN, J.</creatorcontrib><creatorcontrib>VIANDER, M.</creatorcontrib><creatorcontrib>BJÖRKSTEN, B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NERMES, M.</au><au>FÅLTH-MAGNUSSON, K.</au><au>SAVOLAINEN, J.</au><au>VIANDER, M.</au><au>BJÖRKSTEN, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the development of antibody responses to the polysaccharide antigen (Candida albicans mannan) in atopic and healthy infants and children</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>1996-02</date><risdate>1996</risdate><volume>26</volume><issue>2</issue><spage>164</spage><epage>170</epage><pages>164-170</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Background
Defeetive antibody response againsl bacterial polysaccharide antigens is known to be associated with recurrent pyogenic infectiotis. The role of childhood allergy as a risk factor for repeated infections with capsulated micro‐organisms has been controversial.
Objective
To compare the devetopment of polysaccharide specific antibody responses in atopic and healthy infants and children.
Methods
The antibody responses against a common polysaccharide antigen, Candida albicans mannan, were studied longitudinally in 18 atopic and 19 non‐atopic children over the first 5 years of life. Determinations of IgA, IgG and IgM antibodies were carried out by enzyme‐linked immunosorbent assay and IgE antibodies by nitrocellulose‐based radioallergosorbent test.
Results
The polysaccharide specific antibody responses were similar in both groups, except that anti‐mannan IgM levels were higher at 5 years in the atopic children (P<0.05. student's t‐test).
Conclusion
Atopic children are not more susceptible to bacterial infections on the basis of poorer ability to produce antibodies against polysaccharide antigens.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8835123</pmid><doi>10.1111/j.1365-2222.1996.tb00075.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 1996-02, Vol.26 (2), p.164-170 |
| issn | 0954-7894 1365-2222 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Factors Allergic diseases Antibody Formation Antigens - immunology atopy Biological and medical sciences Candida albicans Candida albicans - immunology Child, Preschool children Enzyme-Linked Immunosorbent Assay Female Humans Hypersensitivity, Immediate - immunology Immunoglobulins - analysis Immunopathology Infant infants Male mannan Mannans - immunology Medical sciences Other localizations polysaccharide antigen Radioallergosorbent Test |
| title | A comparison of the development of antibody responses to the polysaccharide antigen (Candida albicans mannan) in atopic and healthy infants and children |
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