Cerebrovascular disorders in patients with diabetes mellitus
Diabetes mellitus is a risk factor for ischemic, but not hemorrhagic stroke. The frequency of transient ischemic attacks is not increased in patients with diabetes compared to the general population. Diabetes mellitus is associated with higher mortality, worse functional outcome, more severe disabil...
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| Veröffentlicht in: | Journal of Diabetes and Its Complications 1996-07, Vol.10 (4), p.228-242 |
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| container_issue | 4 |
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| container_title | Journal of Diabetes and Its Complications |
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| creator | Mankovsky, Boris N Metzger, Boyd E Molitch, Mark E Biller, Jose |
| description | Diabetes mellitus is a risk factor for ischemic, but not hemorrhagic stroke. The frequency of transient ischemic attacks is not increased in patients with diabetes compared to the general population. Diabetes mellitus is associated with higher mortality, worse functional outcome, more severe disability after stroke and a higher frequency of recurrent stroke. Diabetes is not associated with an increased size of cerebral infarction. Controversy exists regarding whether hyperglycemia adversely affects stroke outcome or primarily reflects stroke severity. Cerebral blood flow disturbances, impaired cerebrovascular reactivity, and damage to large and small extra- and intracranial cerebral vessels have been found in humans and animals with diabetes. Combinations of some or all of these factors may underlie the high incidence and worse outcome of stroke in patients with diabetes. Knowledge of these pathophysiologic factors will assist in the design of future intervention strategies. |
| doi_str_mv | 10.1016/S1056-8727(96)90006-9 |
| format | Article |
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The frequency of transient ischemic attacks is not increased in patients with diabetes compared to the general population. Diabetes mellitus is associated with higher mortality, worse functional outcome, more severe disability after stroke and a higher frequency of recurrent stroke. Diabetes is not associated with an increased size of cerebral infarction. Controversy exists regarding whether hyperglycemia adversely affects stroke outcome or primarily reflects stroke severity. Cerebral blood flow disturbances, impaired cerebrovascular reactivity, and damage to large and small extra- and intracranial cerebral vessels have been found in humans and animals with diabetes. Combinations of some or all of these factors may underlie the high incidence and worse outcome of stroke in patients with diabetes. 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The frequency of transient ischemic attacks is not increased in patients with diabetes compared to the general population. Diabetes mellitus is associated with higher mortality, worse functional outcome, more severe disability after stroke and a higher frequency of recurrent stroke. Diabetes is not associated with an increased size of cerebral infarction. Controversy exists regarding whether hyperglycemia adversely affects stroke outcome or primarily reflects stroke severity. Cerebral blood flow disturbances, impaired cerebrovascular reactivity, and damage to large and small extra- and intracranial cerebral vessels have been found in humans and animals with diabetes. Combinations of some or all of these factors may underlie the high incidence and worse outcome of stroke in patients with diabetes. Knowledge of these pathophysiologic factors will assist in the design of future intervention strategies.</description><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - physiopathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cerebrovascular Disorders - complications</subject><subject>Cerebrovascular Disorders - epidemiology</subject><subject>Cerebrovascular Disorders - mortality</subject><subject>Diabetes Complications</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Hyperglycemia - complications</subject><subject>Medical sciences</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVYfoTALEV2MJpNJMgFBpHiDggsV3IVczmBk2qnJTMW3N73YrRA4gf87Fz6ExgRfEkz41QvBjOeVKMS55BcSY8xzuYeGpBI0Lzl-30__P-QQHcX4uWIYIwM0qCrKZMGG6HoCAUxolzravtEhcz62wUGImZ9nC915mHcx-_bdR4q0gQ5iNoOm8V0fj9FBrZsIJ9s6Qm_3d6-Tx3z6_PA0uZ3mtixJl5euwFhyLo0z6QE3rpBMCq2F4wbXQmJBecGIBldLA05QY2onKdGGW2B0hM42cxeh_eohdmrmo01H6Dm0fVSiohXlnCSQbUAb2hgD1GoR_EyHH0WwWllTa2tqpURJrtbWlEx94-2C3szA7bq2mlJ-us2TJt3UQc-tjzuMEl5RzBN2s8EgyVh6CCra5M-C8wFsp1zr_znkF4sSil8</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Mankovsky, Boris N</creator><creator>Metzger, Boyd E</creator><creator>Molitch, Mark E</creator><creator>Biller, Jose</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Cerebrovascular disorders in patients with diabetes mellitus</title><author>Mankovsky, Boris N ; Metzger, Boyd E ; Molitch, Mark E ; Biller, Jose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-4d2009669bdbbdbe6bd29597aa7d6b0f790736251aedf9bed73bbfd931ab6ce53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - physiopathology</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cerebrovascular Disorders - complications</topic><topic>Cerebrovascular Disorders - epidemiology</topic><topic>Cerebrovascular Disorders - mortality</topic><topic>Diabetes Complications</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Hyperglycemia - complications</topic><topic>Medical sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mankovsky, Boris N</creatorcontrib><creatorcontrib>Metzger, Boyd E</creatorcontrib><creatorcontrib>Molitch, Mark E</creatorcontrib><creatorcontrib>Biller, Jose</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Diabetes and Its Complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mankovsky, Boris N</au><au>Metzger, Boyd E</au><au>Molitch, Mark E</au><au>Biller, Jose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrovascular disorders in patients with diabetes mellitus</atitle><jtitle>Journal of Diabetes and Its Complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>10</volume><issue>4</issue><spage>228</spage><epage>242</epage><pages>228-242</pages><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>Diabetes mellitus is a risk factor for ischemic, but not hemorrhagic stroke. 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| identifier | ISSN: 1056-8727 |
| ispartof | Journal of Diabetes and Its Complications, 1996-07, Vol.10 (4), p.228-242 |
| issn | 1056-8727 1873-460X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Associated diseases and complications Biological and medical sciences Brain Ischemia - complications Brain Ischemia - physiopathology Cerebrovascular Circulation - physiology Cerebrovascular Disorders - complications Cerebrovascular Disorders - epidemiology Cerebrovascular Disorders - mortality Diabetes Complications Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Hemodynamics Humans Hyperglycemia - complications Medical sciences |
| title | Cerebrovascular disorders in patients with diabetes mellitus |
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