Effect of magnesium on plasma cholinesterase activity
Plasma cholinesterase activity levels were studied in 15 pregnant patients with preeclampsia before and after the administration of therapeutic doses of magnesium sulfate. Plasma cholinesterase activity was also studied in 15 healthy nonpregnant and 15 healthy pregnant women. The mean plasma choline...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1988-08, Vol.159 (2), p.309-311 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Kambam, J. Reddy Perry, Stephanie M. Entman, Stephan Smith, Bradley E. |
| description | Plasma cholinesterase activity levels were studied in 15 pregnant patients with preeclampsia before and after the administration of therapeutic doses of magnesium sulfate. Plasma cholinesterase activity was also studied in 15 healthy nonpregnant and 15 healthy pregnant women. The mean plasma cholinesterase activity level in pregnant patients with preeclampsia before and after the administration of magnesium sulfate was 179 α 26 and 176 α 39 units/ml, respectively. The healthy nonpregnant patients and healthy pregnant patients had a plasma cholinesterase activity level of 426 α 85 and 264 α 24 units/ml, respectively. Our data demonstrated that magnesium has no significant effect on plasma cholinesterase activity. Our data also confirm that there is a significant reduction in plasma cholinesterase activity in pregnant patients with preeclampsia compared with either healthy nonpregnant or healthy pregnant patients. We conclude that the low level of plasma cholinesterase activity is probably responsible for the prolonged action of succinylcholine in pregnant patients with preeclampsia receiving magnesium sulfate. |
| doi_str_mv | 10.1016/S0002-9378(88)80073-5 |
| format | Article |
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Reddy ; Perry, Stephanie M. ; Entman, Stephan ; Smith, Bradley E.</creator><creatorcontrib>Kambam, J. Reddy ; Perry, Stephanie M. ; Entman, Stephan ; Smith, Bradley E.</creatorcontrib><description>Plasma cholinesterase activity levels were studied in 15 pregnant patients with preeclampsia before and after the administration of therapeutic doses of magnesium sulfate. Plasma cholinesterase activity was also studied in 15 healthy nonpregnant and 15 healthy pregnant women. The mean plasma cholinesterase activity level in pregnant patients with preeclampsia before and after the administration of magnesium sulfate was 179 α 26 and 176 α 39 units/ml, respectively. The healthy nonpregnant patients and healthy pregnant patients had a plasma cholinesterase activity level of 426 α 85 and 264 α 24 units/ml, respectively. Our data demonstrated that magnesium has no significant effect on plasma cholinesterase activity. Our data also confirm that there is a significant reduction in plasma cholinesterase activity in pregnant patients with preeclampsia compared with either healthy nonpregnant or healthy pregnant patients. We conclude that the low level of plasma cholinesterase activity is probably responsible for the prolonged action of succinylcholine in pregnant patients with preeclampsia receiving magnesium sulfate.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(88)80073-5</identifier><identifier>PMID: 3407685</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cholinesterases - blood ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Magnesium sulfate ; Magnesium Sulfate - pharmacology ; Medical sciences ; plasma cholinesterase ; Pre-Eclampsia - blood ; Pre-Eclampsia - enzymology ; preeclampsia ; Pregnancy ; pregnancy-induced hypertension ; Pregnancy. Fetus. Placenta ; toxemia of pregnancy</subject><ispartof>American journal of obstetrics and gynecology, 1988-08, Vol.159 (2), p.309-311</ispartof><rights>1988 C. V. 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Reddy</creatorcontrib><creatorcontrib>Perry, Stephanie M.</creatorcontrib><creatorcontrib>Entman, Stephan</creatorcontrib><creatorcontrib>Smith, Bradley E.</creatorcontrib><title>Effect of magnesium on plasma cholinesterase activity</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Plasma cholinesterase activity levels were studied in 15 pregnant patients with preeclampsia before and after the administration of therapeutic doses of magnesium sulfate. Plasma cholinesterase activity was also studied in 15 healthy nonpregnant and 15 healthy pregnant women. The mean plasma cholinesterase activity level in pregnant patients with preeclampsia before and after the administration of magnesium sulfate was 179 α 26 and 176 α 39 units/ml, respectively. The healthy nonpregnant patients and healthy pregnant patients had a plasma cholinesterase activity level of 426 α 85 and 264 α 24 units/ml, respectively. Our data demonstrated that magnesium has no significant effect on plasma cholinesterase activity. Our data also confirm that there is a significant reduction in plasma cholinesterase activity in pregnant patients with preeclampsia compared with either healthy nonpregnant or healthy pregnant patients. We conclude that the low level of plasma cholinesterase activity is probably responsible for the prolonged action of succinylcholine in pregnant patients with preeclampsia receiving magnesium sulfate.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cholinesterases - blood</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Magnesium sulfate</subject><subject>Magnesium Sulfate - pharmacology</subject><subject>Medical sciences</subject><subject>plasma cholinesterase</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - enzymology</subject><subject>preeclampsia</subject><subject>Pregnancy</subject><subject>pregnancy-induced hypertension</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>toxemia of pregnancy</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVYfQZiFiC5Gk8nkthIp9QIFF-o6ZNIzGplLTWYKfXsz7dCtEAjJ-c45Px9ClwTfEUz4_TvGOEsVFfJGyluJsaApO0JTgpVIueTyGE0PyCk6C-FneGYqm6AJzbHgkk0RW5Ql2C5py6Q2Xw0E19dJ2yTryoTaJPa7rVz87cCbAImxndu4bnuOTkpTBbgY7xn6fFp8zF_S5dvz6_xxmdo8J12qhFAFozFuRi0mUFCWc4NxAXkhcysYUFpyQQwXUnCiVMGxYSy3mVIlkYrO0PV-7tq3v32MoWsXLFSVaaDtgxaSSsqpiCDbg9a3IXgo9dq72vitJlgPuvROlx5caBnPoEuz2Hc5LuiLGlaHrtFPrF-NdROsqUpvGuvCAeNMKblb_7DHIMrYOPA6WAeNhZXz0a5ete6fIH9cgYR-</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>Kambam, J. Reddy</creator><creator>Perry, Stephanie M.</creator><creator>Entman, Stephan</creator><creator>Smith, Bradley E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880801</creationdate><title>Effect of magnesium on plasma cholinesterase activity</title><author>Kambam, J. Reddy ; Perry, Stephanie M. ; Entman, Stephan ; Smith, Bradley E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-9779b5310123c01eb3546a00be4b84c75e33f671a67876199b60a554c299f1893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cholinesterases - blood</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Magnesium sulfate</topic><topic>Magnesium Sulfate - pharmacology</topic><topic>Medical sciences</topic><topic>plasma cholinesterase</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - enzymology</topic><topic>preeclampsia</topic><topic>Pregnancy</topic><topic>pregnancy-induced hypertension</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>toxemia of pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kambam, J. Reddy</creatorcontrib><creatorcontrib>Perry, Stephanie M.</creatorcontrib><creatorcontrib>Entman, Stephan</creatorcontrib><creatorcontrib>Smith, Bradley E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kambam, J. Reddy</au><au>Perry, Stephanie M.</au><au>Entman, Stephan</au><au>Smith, Bradley E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of magnesium on plasma cholinesterase activity</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1988-08-01</date><risdate>1988</risdate><volume>159</volume><issue>2</issue><spage>309</spage><epage>311</epage><pages>309-311</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Plasma cholinesterase activity levels were studied in 15 pregnant patients with preeclampsia before and after the administration of therapeutic doses of magnesium sulfate. Plasma cholinesterase activity was also studied in 15 healthy nonpregnant and 15 healthy pregnant women. The mean plasma cholinesterase activity level in pregnant patients with preeclampsia before and after the administration of magnesium sulfate was 179 α 26 and 176 α 39 units/ml, respectively. The healthy nonpregnant patients and healthy pregnant patients had a plasma cholinesterase activity level of 426 α 85 and 264 α 24 units/ml, respectively. Our data demonstrated that magnesium has no significant effect on plasma cholinesterase activity. Our data also confirm that there is a significant reduction in plasma cholinesterase activity in pregnant patients with preeclampsia compared with either healthy nonpregnant or healthy pregnant patients. We conclude that the low level of plasma cholinesterase activity is probably responsible for the prolonged action of succinylcholine in pregnant patients with preeclampsia receiving magnesium sulfate.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>3407685</pmid><doi>10.1016/S0002-9378(88)80073-5</doi><tpages>3</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1988-08, Vol.159 (2), p.309-311 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Biological and medical sciences Cholinesterases - blood Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Magnesium sulfate Magnesium Sulfate - pharmacology Medical sciences plasma cholinesterase Pre-Eclampsia - blood Pre-Eclampsia - enzymology preeclampsia Pregnancy pregnancy-induced hypertension Pregnancy. Fetus. Placenta toxemia of pregnancy |
| title | Effect of magnesium on plasma cholinesterase activity |
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