Seroconversion Patterns to Four Human Rotavirus Serotypes in Hospitalized Infants with Acute Rotavirus Gastroenteritis
We studied rotavirus-specific antibodies in paired sera from 71 hospitalized infants with acute rotavirus gastroenteritis. Most of the infants were less than six months old. Infants with serological evidence of a secondary rotavirus infection were excluded. With an enzyme-linked immunosorbent assay,...
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| Veröffentlicht in: | The Journal of infectious diseases 1988-09, Vol.158 (3), p.588-595 |
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| container_title | The Journal of infectious diseases |
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| creator | Brüssow, Harald Werchao, Hermann Lerner, Lothar Mietens, Carl Liedtke, Wolfgang Sidoti, Josette Sotek, Jan |
| description | We studied rotavirus-specific antibodies in paired sera from 71 hospitalized infants with acute rotavirus gastroenteritis. Most of the infants were less than six months old. Infants with serological evidence of a secondary rotavirus infection were excluded. With an enzyme-linked immunosorbent assay, 46% of the 71 infants studied showed specific IgM in convalescent sera. Titers of specific IgG and IgA increased in 7% and 2% of the infants, respectively. The presence of specific IgM correlated positively with age and severity of clinical symptoms. With a neutralization test, 59% of the infants showed a seroconversion: 20% to a single serotype (7% to serotype 1, 7% to serotype 3, and 6% to serotype 4), 21% seroconverted to two serotypes (nearly exclusivelyto serotypes 1and 3), and 18% seroconverted to three serotypes (exclusively to serotypes 1, 3, and 4). No infant seroconverted to serotype 2 or to the heterologous (bovine) serotype 6. |
| doi_str_mv | 10.1093/infdis/158.3.588 |
| format | Article |
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Most of the infants were less than six months old. Infants with serological evidence of a secondary rotavirus infection were excluded. With an enzyme-linked immunosorbent assay, 46% of the 71 infants studied showed specific IgM in convalescent sera. Titers of specific IgG and IgA increased in 7% and 2% of the infants, respectively. The presence of specific IgM correlated positively with age and severity of clinical symptoms. With a neutralization test, 59% of the infants showed a seroconversion: 20% to a single serotype (7% to serotype 1, 7% to serotype 3, and 6% to serotype 4), 21% seroconverted to two serotypes (nearly exclusivelyto serotypes 1and 3), and 18% seroconverted to three serotypes (exclusively to serotypes 1, 3, and 4). 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Most of the infants were less than six months old. Infants with serological evidence of a secondary rotavirus infection were excluded. With an enzyme-linked immunosorbent assay, 46% of the 71 infants studied showed specific IgM in convalescent sera. Titers of specific IgG and IgA increased in 7% and 2% of the infants, respectively. The presence of specific IgM correlated positively with age and severity of clinical symptoms. With a neutralization test, 59% of the infants showed a seroconversion: 20% to a single serotype (7% to serotype 1, 7% to serotype 3, and 6% to serotype 4), 21% seroconverted to two serotypes (nearly exclusivelyto serotypes 1and 3), and 18% seroconverted to three serotypes (exclusively to serotypes 1, 3, and 4). No infant seroconverted to serotype 2 or to the heterologous (bovine) serotype 6.</description><subject>Age Factors</subject><subject>Antibodies</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Diarrhea</subject><subject>Enzyme linked immunosorbent assay</subject><subject>Female</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Infant</subject><subject>Infants</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monoclonal antibodies</subject><subject>Neutralization Tests</subject><subject>Neutralizing antibodies</subject><subject>Original Articles</subject><subject>Rotavirus</subject><subject>Rotavirus - classification</subject><subject>Rotavirus - immunology</subject><subject>Rotavirus infections</subject><subject>Rotavirus Infections - immunology</subject><subject>Serotyping</subject><subject>Viral diseases</subject><subject>Viral diseases of the digestive system</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEURS1EVUJhzwbJC8RuUn-MPZ5lFdGmqCoVtFLVjeXxeITLxE79PIHy63GVNLBj9Rbn3iM9XYTeUTKnpOXHPgy9h2Mq1JzPhVIv0IwK3lRSUv4SzQhhrKKqbV-h1wD3hJCay-YQHTJVs5rIGdp8cynaGDYugY8BX5mcXQqAc8SncUp4Oa1MwF9jNhufJsBP-fy4doB9wMsIa5_N6H-7Hp-HwYQM-KfP3_GJnbL7p3ZmIKfoQpH77OENOhjMCO7t7h6hm9NP14tldfHl7HxxclFZztpcubY3xgnSKtuJzrZc8cFSLlzfsa4zVtCmV3XDWtkpUTPVE6pYRwSVkjk51PwIfdx61yk-TA6yXnmwbhxNcHEC3aiipJT-N0gFkZSppgTJNmhTBEhu0OvkVyY9akr00yZ6u0lpKM112aRU3u_cU7dy_b6wG6HwDztuwJpxSCbYIniOybapFRd_NfeQY9pjTihvyvOFV1vuIbtfe27SDy2bEtHL2ztdXy0u6-u7z_qS_wHmMLE5</recordid><startdate>198809</startdate><enddate>198809</enddate><creator>Brüssow, Harald</creator><creator>Werchao, Hermann</creator><creator>Lerner, Lothar</creator><creator>Mietens, Carl</creator><creator>Liedtke, Wolfgang</creator><creator>Sidoti, Josette</creator><creator>Sotek, Jan</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198809</creationdate><title>Seroconversion Patterns to Four Human Rotavirus Serotypes in Hospitalized Infants with Acute Rotavirus Gastroenteritis</title><author>Brüssow, Harald ; Werchao, Hermann ; Lerner, Lothar ; Mietens, Carl ; Liedtke, Wolfgang ; Sidoti, Josette ; Sotek, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-e9daae5098cb5bc9383fc135edb2bbac517d847296b85428d0182b051662e6f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Age Factors</topic><topic>Antibodies</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Diarrhea</topic><topic>Enzyme linked immunosorbent assay</topic><topic>Female</topic><topic>Gastroenteritis</topic><topic>Gastroenteritis - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Infant</topic><topic>Infants</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monoclonal antibodies</topic><topic>Neutralization Tests</topic><topic>Neutralizing antibodies</topic><topic>Original Articles</topic><topic>Rotavirus</topic><topic>Rotavirus - classification</topic><topic>Rotavirus - immunology</topic><topic>Rotavirus infections</topic><topic>Rotavirus Infections - immunology</topic><topic>Serotyping</topic><topic>Viral diseases</topic><topic>Viral diseases of the digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brüssow, Harald</creatorcontrib><creatorcontrib>Werchao, Hermann</creatorcontrib><creatorcontrib>Lerner, Lothar</creatorcontrib><creatorcontrib>Mietens, Carl</creatorcontrib><creatorcontrib>Liedtke, Wolfgang</creatorcontrib><creatorcontrib>Sidoti, Josette</creatorcontrib><creatorcontrib>Sotek, Jan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brüssow, Harald</au><au>Werchao, Hermann</au><au>Lerner, Lothar</au><au>Mietens, Carl</au><au>Liedtke, Wolfgang</au><au>Sidoti, Josette</au><au>Sotek, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroconversion Patterns to Four Human Rotavirus Serotypes in Hospitalized Infants with Acute Rotavirus Gastroenteritis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1988-09</date><risdate>1988</risdate><volume>158</volume><issue>3</issue><spage>588</spage><epage>595</epage><pages>588-595</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We studied rotavirus-specific antibodies in paired sera from 71 hospitalized infants with acute rotavirus gastroenteritis. Most of the infants were less than six months old. Infants with serological evidence of a secondary rotavirus infection were excluded. With an enzyme-linked immunosorbent assay, 46% of the 71 infants studied showed specific IgM in convalescent sera. Titers of specific IgG and IgA increased in 7% and 2% of the infants, respectively. The presence of specific IgM correlated positively with age and severity of clinical symptoms. With a neutralization test, 59% of the infants showed a seroconversion: 20% to a single serotype (7% to serotype 1, 7% to serotype 3, and 6% to serotype 4), 21% seroconverted to two serotypes (nearly exclusivelyto serotypes 1and 3), and 18% seroconverted to three serotypes (exclusively to serotypes 1, 3, and 4). No infant seroconverted to serotype 2 or to the heterologous (bovine) serotype 6.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>2842406</pmid><doi>10.1093/infdis/158.3.588</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1988-09, Vol.158 (3), p.588-595 |
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| subjects | Age Factors Antibodies Antibodies, Viral - biosynthesis Biological and medical sciences Diarrhea Enzyme linked immunosorbent assay Female Gastroenteritis Gastroenteritis - immunology Human viral diseases Humans Immune response Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Infant Infants Infectious diseases Male Medical sciences Monoclonal antibodies Neutralization Tests Neutralizing antibodies Original Articles Rotavirus Rotavirus - classification Rotavirus - immunology Rotavirus infections Rotavirus Infections - immunology Serotyping Viral diseases Viral diseases of the digestive system |
| title | Seroconversion Patterns to Four Human Rotavirus Serotypes in Hospitalized Infants with Acute Rotavirus Gastroenteritis |
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