Compensatory mechanisms in erythrocyte lipids in patients with atherosclerosis
The quantitative coposition of phospholipids and fatty acids of erythrocytes was investigated in patients with atherosclerosis. It was stated that the erythrocyte lipids of atherosclerotic patients contained smaller quantitities of phosphatidylcholine and phosphatidylinositol, a significantly larger...
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| Veröffentlicht in: | Lipids 1988-05, Vol.23 (5), p.476-480 |
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| container_title | Lipids |
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| creator | Michalak, Jerzy Kadziolka, Adam Pruszkowska, Romualda Ledwozyw, Andrzej Madejczyk, Andrej |
| description | The quantitative coposition of phospholipids and fatty acids of erythrocytes was investigated in patients with atherosclerosis. It was stated that the erythrocyte lipids of atherosclerotic patients contained smaller quantitities of phosphatidylcholine and phosphatidylinositol, a significantly larger quantity of sphingomyelin, and higher sphingomyelin/phosphatidylcholine and cholesterol/phospholipid ratios. The existence of compensatory changes was stated, which was evident in the reduction of palmitic and stearic acids and the increase of linoleic and eicosatrienoic acids in erythrocyte phospholipids. These changes in fatty acid composition probably cause minimal changes in the membrane fluidity indiced by an increased cholesterol/phospholipid and sphingomyelin/phosphatidylcholine ratios. This paper was the first evidence of occurrence of those changes in erythrocytes during spontaneous atherosclerosis in human |
| doi_str_mv | 10.1007/BF02535523 |
| format | Article |
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It was stated that the erythrocyte lipids of atherosclerotic patients contained smaller quantitities of phosphatidylcholine and phosphatidylinositol, a significantly larger quantity of sphingomyelin, and higher sphingomyelin/phosphatidylcholine and cholesterol/phospholipid ratios. The existence of compensatory changes was stated, which was evident in the reduction of palmitic and stearic acids and the increase of linoleic and eicosatrienoic acids in erythrocyte phospholipids. These changes in fatty acid composition probably cause minimal changes in the membrane fluidity indiced by an increased cholesterol/phospholipid and sphingomyelin/phosphatidylcholine ratios. 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It was stated that the erythrocyte lipids of atherosclerotic patients contained smaller quantitities of phosphatidylcholine and phosphatidylinositol, a significantly larger quantity of sphingomyelin, and higher sphingomyelin/phosphatidylcholine and cholesterol/phospholipid ratios. The existence of compensatory changes was stated, which was evident in the reduction of palmitic and stearic acids and the increase of linoleic and eicosatrienoic acids in erythrocyte phospholipids. These changes in fatty acid composition probably cause minimal changes in the membrane fluidity indiced by an increased cholesterol/phospholipid and sphingomyelin/phosphatidylcholine ratios. This paper was the first evidence of occurrence of those changes in erythrocytes during spontaneous atherosclerosis in human</description><subject>Arteriosclerosis - blood</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - blood</subject><subject>Erythrocytes - metabolism</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Phospholipids - blood</subject><subject>Triglycerides - blood</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotT427oVZiAthNDePSWap1WqhqAtdD2maMJF5maSU-fdObak7N_f5ce7lIHQB-BYwFncPU0w45ZzQAzQGzmWaUywO0RhjwlJGMByjkxC-hhZYzkdoRBkQIHKMXidt3ZkmqNj6PqmNLlXjQh0S1yTG97H0re6jSSrXueXvtFPRmSaGZO1imahYGt8GXW2iC2foyKoqmPNdPkWf06ePyUs6f3ueTe7nqaacZCmlipOlJFJpIXMAKSQjRHGWg2GUAtfcaosBLFtkGkuwQ8mJ1QwkGMXpKbre6na-_V6ZEIvaBW2qSjWmXYVCSCohg2wAb7agHv4L3tii865Wvi8AFxvzij_zBvhyp7pa1Ga5R3duDfur3V4FrSrrVaNd2GOCCkozPGB4i61dZfp_Dhbz2fsjZiKjP_Vvg_Q</recordid><startdate>198805</startdate><enddate>198805</enddate><creator>Michalak, Jerzy</creator><creator>Kadziolka, Adam</creator><creator>Pruszkowska, Romualda</creator><creator>Ledwozyw, Andrzej</creator><creator>Madejczyk, Andrej</creator><general>Springer‐Verlag</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198805</creationdate><title>Compensatory mechanisms in erythrocyte lipids in patients with atherosclerosis</title><author>Michalak, Jerzy ; Kadziolka, Adam ; Pruszkowska, Romualda ; Ledwozyw, Andrzej ; Madejczyk, Andrej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3526-33a52d828ac78911878422a5491e43315c5fcf011f4b6c081f11f52fc4181ea53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Arteriosclerosis - blood</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>Erythrocytes - metabolism</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Phospholipids - blood</topic><topic>Triglycerides - blood</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michalak, Jerzy</creatorcontrib><creatorcontrib>Kadziolka, Adam</creatorcontrib><creatorcontrib>Pruszkowska, Romualda</creatorcontrib><creatorcontrib>Ledwozyw, Andrzej</creatorcontrib><creatorcontrib>Madejczyk, Andrej</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michalak, Jerzy</au><au>Kadziolka, Adam</au><au>Pruszkowska, Romualda</au><au>Ledwozyw, Andrzej</au><au>Madejczyk, Andrej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compensatory mechanisms in erythrocyte lipids in patients with atherosclerosis</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>1988-05</date><risdate>1988</risdate><volume>23</volume><issue>5</issue><spage>476</spage><epage>480</epage><pages>476-480</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><coden>LPDSAP</coden><abstract>The quantitative coposition of phospholipids and fatty acids of erythrocytes was investigated in patients with atherosclerosis. 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| fulltext | fulltext |
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| ispartof | Lipids, 1988-05, Vol.23 (5), p.476-480 |
| issn | 0024-4201 1558-9307 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Arteriosclerosis - blood Biological and medical sciences Cholesterol - blood Erythrocytes - metabolism Humans Lipids - blood Male Medical sciences Neurology Phospholipids - blood Triglycerides - blood Vascular diseases and vascular malformations of the nervous system |
| title | Compensatory mechanisms in erythrocyte lipids in patients with atherosclerosis |
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