Prostaglandin H Synthase-Catalyzed Oxidation of all-trans- and 13-cis-Retinoic Acid to Carbon-Centered and Peroxyl Radical Intermediates

Due to the importance of all-trans-retinoic acid (RA) in the treatment of various dermatological conditions and the wide distribution of prostaglandin H synthase (PGHS) in tissues, we have further examined the mechanisms involved in the hydroperoxide-dependent cooxidation of RA and its isomer, 13-ci...

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