A Kinetic Study on Drug Distribution : Furosemide in Rats

To rationalize the observed time courses of furosemide distribution in arbitrarily selected tissues of rats, a phaarmacokinetic analysis based on the perfusion rate-limited model was carried out. Anatomical compartments include liver, kidneys, intestine, muscle and plasma. Required parameters were e...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1988/03/25, Vol.36(3), pp.1053-1062
Hauptverfasser:	KITANI, MAMI, OZAKI, YUKIKO, KITAYAMA, KAZUNORI, KAKEMI, MASAWO, KOIZUMI, TAMOTSU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Furosemide - pharmacokinetics Male Medical sciences perfusion rate-limited distribution Pharmacology. Drug treatments Rats Rats, Inbred Strains Tissue Distribution Urinary system
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Beschreibung
Zusammenfassung:	To rationalize the observed time courses of furosemide distribution in arbitrarily selected tissues of rats, a phaarmacokinetic analysis based on the perfusion rate-limited model was carried out. Anatomical compartments include liver, kidneys, intestine, muscle and plasma. Required parameters were estimated on the basis of physiological principles for rats.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.36.1053