Regulation of body fluid compartments during short-term spaceflight
C. S. Leach, C. P. Alfrey, W. N. Suki, J. I. Leonard, P. C. Rambaut, L. D. Inners, S. M. Smith, H. W. Lane and J. M. Krauhs Biomedical Operations and Research Branch, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA. The fluid and electrolyte regulation experim...
Gespeichert in:
| Veröffentlicht in: | Journal of applied physiology (1985) 1996-07, Vol.81 (1), p.105-116 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 116 |
|---|---|
| container_issue | 1 |
| container_start_page | 105 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 81 |
| creator | Leach, C. S Alfrey, C. P Suki, W. N Leonard, J. I Rambaut, P. C Inners, L. D Smith, S. M Lane, H. W Krauhs, J. M |
| description | C. S. Leach, C. P. Alfrey, W. N. Suki, J. I. Leonard, P. C. Rambaut, L. D. Inners, S. M. Smith, H. W. Lane and J. M. Krauhs
Biomedical Operations and Research Branch, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
The fluid and electrolyte regulation experiment with seven subjects was
designed to describe body fluid, renal, and fluid regulatory hormone
responses during the Spacelab Life Sciences-1 (9 days) and -2 (14 days)
missions. Total body water did not change significantly. Plasma volume (PV;
P < 0.05) and extracellular fluid volume (ECFV; P < 0.10) decreased
21 h after launch, remaining below preflight levels until after landing.
Fluid intake decreased during weightlessness, and glomerular filtration
rate (GFR) increased in the first 2 days and on day 8 (P < 0.05).
Urinary antidiuretic hormone (ADH) excretion increased (P < 0.05) and
fluid excretion decreased early in flight (P < 0.10). Plasma renin
activity (PRA; P < 0.10) and aldosterone (P < 0.05) decreased in the
first few hours after launch; PRA increased 1 wk later (P < 0.05).
During flight, plasma atrial natriuretic peptide concentrations were
consistently lower than preflight means, and urinary cortisol excretion was
usually greater than preflight levels. Acceleration at launch and landing
probably caused increases in ADH and cortisol excretion, and a shift of
fluid from the extracellular to the intracellular compartment would account
for reductions in ECFV. Increased permeability of capillary membranes may
be the most important mechanism causing spaceflight-induced PV reduction,
which is probably maintained by increased GFR and other mechanisms. If the
Gauer-Henry reflex operates during spaceflight, it must be completed within
the first 21 h of flight and be succeeded by establishment of a reduced PV
set point. |
| doi_str_mv | 10.1152/jappl.1996.81.1.105 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_78379321</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>26353965</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-7b71ceff0a036fd2a6a1e145be0a998abf4c113871e7eac9ca5c30eb72aef2e83</originalsourceid><addsrcrecordid>eNqFkM9LwzAYhoMoc07_AhF60lNnvqRp0qMMf8FAED2HNP2yVdqlJi2y_97ODT3Kd_gO7_s-h4eQS6BzAMFuP0zXNXMoinyuYD4eFUdkOiYshZzCMZkqKWgqhZKn5CzGD0ohywRMyEQppnLBpmTxiquhMX3tN4l3SemrbeKaoa4S69vOhL7FTR-Tagj1ZpXEtQ992mNok9gZi66pV-v-nJw400S8OPwZeX-4f1s8pcuXx-fF3TK1GSv6VJYSxomjhvLcVczkBhAyUSI1RaFM6TILwJUElGhsYY2wnGIpmUHHUPEZud5zu-A_B4y9butosWnMBv0QtVRcFpzBv0WWc8GLXIxFvi_a4GMM6HQX6taErQaqd471j2O9c6wV6PHobnV1wA9li9Xv5iB1zG_2-Xq081UH1N16G2vf-NV2B_wjfQOcCoiC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>26353965</pqid></control><display><type>article</type><title>Regulation of body fluid compartments during short-term spaceflight</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Leach, C. S ; Alfrey, C. P ; Suki, W. N ; Leonard, J. I ; Rambaut, P. C ; Inners, L. D ; Smith, S. M ; Lane, H. W ; Krauhs, J. M</creator><creatorcontrib>Leach, C. S ; Alfrey, C. P ; Suki, W. N ; Leonard, J. I ; Rambaut, P. C ; Inners, L. D ; Smith, S. M ; Lane, H. W ; Krauhs, J. M</creatorcontrib><description><![CDATA[C. S. Leach, C. P. Alfrey, W. N. Suki, J. I. Leonard, P. C. Rambaut, L. D. Inners, S. M. Smith, H. W. Lane and J. M. Krauhs
Biomedical Operations and Research Branch, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
The fluid and electrolyte regulation experiment with seven subjects was
designed to describe body fluid, renal, and fluid regulatory hormone
responses during the Spacelab Life Sciences-1 (9 days) and -2 (14 days)
missions. Total body water did not change significantly. Plasma volume (PV;
P < 0.05) and extracellular fluid volume (ECFV; P < 0.10) decreased
21 h after launch, remaining below preflight levels until after landing.
Fluid intake decreased during weightlessness, and glomerular filtration
rate (GFR) increased in the first 2 days and on day 8 (P < 0.05).
Urinary antidiuretic hormone (ADH) excretion increased (P < 0.05) and
fluid excretion decreased early in flight (P < 0.10). Plasma renin
activity (PRA; P < 0.10) and aldosterone (P < 0.05) decreased in the
first few hours after launch; PRA increased 1 wk later (P < 0.05).
During flight, plasma atrial natriuretic peptide concentrations were
consistently lower than preflight means, and urinary cortisol excretion was
usually greater than preflight levels. Acceleration at launch and landing
probably caused increases in ADH and cortisol excretion, and a shift of
fluid from the extracellular to the intracellular compartment would account
for reductions in ECFV. Increased permeability of capillary membranes may
be the most important mechanism causing spaceflight-induced PV reduction,
which is probably maintained by increased GFR and other mechanisms. If the
Gauer-Henry reflex operates during spaceflight, it must be completed within
the first 21 h of flight and be succeeded by establishment of a reduced PV
set point.]]></description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1996.81.1.105</identifier><identifier>PMID: 8828652</identifier><language>eng</language><publisher>United States: Am Physiological Soc</publisher><subject>Adult ; Body Fluid Compartments - physiology ; Body Water - physiology ; Body Weight - physiology ; Diet ; Female ; Glomerular Filtration Rate - physiology ; Humans ; Kidney Function Tests ; Leg - anatomy & histology ; Leg - blood supply ; Male ; Middle Aged ; Plasma Volume - physiology ; Regional Blood Flow - physiology ; Space Flight ; Space life sciences ; Urodynamics - physiology ; Water-Electrolyte Balance - physiology ; Weightlessness - adverse effects ; Weightlessness Countermeasures</subject><ispartof>Journal of applied physiology (1985), 1996-07, Vol.81 (1), p.105-116</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-7b71ceff0a036fd2a6a1e145be0a998abf4c113871e7eac9ca5c30eb72aef2e83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8828652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leach, C. S</creatorcontrib><creatorcontrib>Alfrey, C. P</creatorcontrib><creatorcontrib>Suki, W. N</creatorcontrib><creatorcontrib>Leonard, J. I</creatorcontrib><creatorcontrib>Rambaut, P. C</creatorcontrib><creatorcontrib>Inners, L. D</creatorcontrib><creatorcontrib>Smith, S. M</creatorcontrib><creatorcontrib>Lane, H. W</creatorcontrib><creatorcontrib>Krauhs, J. M</creatorcontrib><title>Regulation of body fluid compartments during short-term spaceflight</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description><![CDATA[C. S. Leach, C. P. Alfrey, W. N. Suki, J. I. Leonard, P. C. Rambaut, L. D. Inners, S. M. Smith, H. W. Lane and J. M. Krauhs
Biomedical Operations and Research Branch, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
The fluid and electrolyte regulation experiment with seven subjects was
designed to describe body fluid, renal, and fluid regulatory hormone
responses during the Spacelab Life Sciences-1 (9 days) and -2 (14 days)
missions. Total body water did not change significantly. Plasma volume (PV;
P < 0.05) and extracellular fluid volume (ECFV; P < 0.10) decreased
21 h after launch, remaining below preflight levels until after landing.
Fluid intake decreased during weightlessness, and glomerular filtration
rate (GFR) increased in the first 2 days and on day 8 (P < 0.05).
Urinary antidiuretic hormone (ADH) excretion increased (P < 0.05) and
fluid excretion decreased early in flight (P < 0.10). Plasma renin
activity (PRA; P < 0.10) and aldosterone (P < 0.05) decreased in the
first few hours after launch; PRA increased 1 wk later (P < 0.05).
During flight, plasma atrial natriuretic peptide concentrations were
consistently lower than preflight means, and urinary cortisol excretion was
usually greater than preflight levels. Acceleration at launch and landing
probably caused increases in ADH and cortisol excretion, and a shift of
fluid from the extracellular to the intracellular compartment would account
for reductions in ECFV. Increased permeability of capillary membranes may
be the most important mechanism causing spaceflight-induced PV reduction,
which is probably maintained by increased GFR and other mechanisms. If the
Gauer-Henry reflex operates during spaceflight, it must be completed within
the first 21 h of flight and be succeeded by establishment of a reduced PV
set point.]]></description><subject>Adult</subject><subject>Body Fluid Compartments - physiology</subject><subject>Body Water - physiology</subject><subject>Body Weight - physiology</subject><subject>Diet</subject><subject>Female</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Kidney Function Tests</subject><subject>Leg - anatomy & histology</subject><subject>Leg - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasma Volume - physiology</subject><subject>Regional Blood Flow - physiology</subject><subject>Space Flight</subject><subject>Space life sciences</subject><subject>Urodynamics - physiology</subject><subject>Water-Electrolyte Balance - physiology</subject><subject>Weightlessness - adverse effects</subject><subject>Weightlessness Countermeasures</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAYhoMoc07_AhF60lNnvqRp0qMMf8FAED2HNP2yVdqlJi2y_97ODT3Kd_gO7_s-h4eQS6BzAMFuP0zXNXMoinyuYD4eFUdkOiYshZzCMZkqKWgqhZKn5CzGD0ohywRMyEQppnLBpmTxiquhMX3tN4l3SemrbeKaoa4S69vOhL7FTR-Tagj1ZpXEtQ992mNok9gZi66pV-v-nJw400S8OPwZeX-4f1s8pcuXx-fF3TK1GSv6VJYSxomjhvLcVczkBhAyUSI1RaFM6TILwJUElGhsYY2wnGIpmUHHUPEZud5zu-A_B4y9butosWnMBv0QtVRcFpzBv0WWc8GLXIxFvi_a4GMM6HQX6taErQaqd471j2O9c6wV6PHobnV1wA9li9Xv5iB1zG_2-Xq081UH1N16G2vf-NV2B_wjfQOcCoiC</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Leach, C. S</creator><creator>Alfrey, C. P</creator><creator>Suki, W. N</creator><creator>Leonard, J. I</creator><creator>Rambaut, P. C</creator><creator>Inners, L. D</creator><creator>Smith, S. M</creator><creator>Lane, H. W</creator><creator>Krauhs, J. M</creator><general>Am Physiological Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>H8D</scope><scope>KR7</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Regulation of body fluid compartments during short-term spaceflight</title><author>Leach, C. S ; Alfrey, C. P ; Suki, W. N ; Leonard, J. I ; Rambaut, P. C ; Inners, L. D ; Smith, S. M ; Lane, H. W ; Krauhs, J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-7b71ceff0a036fd2a6a1e145be0a998abf4c113871e7eac9ca5c30eb72aef2e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Body Fluid Compartments - physiology</topic><topic>Body Water - physiology</topic><topic>Body Weight - physiology</topic><topic>Diet</topic><topic>Female</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Humans</topic><topic>Kidney Function Tests</topic><topic>Leg - anatomy & histology</topic><topic>Leg - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasma Volume - physiology</topic><topic>Regional Blood Flow - physiology</topic><topic>Space Flight</topic><topic>Space life sciences</topic><topic>Urodynamics - physiology</topic><topic>Water-Electrolyte Balance - physiology</topic><topic>Weightlessness - adverse effects</topic><topic>Weightlessness Countermeasures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leach, C. S</creatorcontrib><creatorcontrib>Alfrey, C. P</creatorcontrib><creatorcontrib>Suki, W. N</creatorcontrib><creatorcontrib>Leonard, J. I</creatorcontrib><creatorcontrib>Rambaut, P. C</creatorcontrib><creatorcontrib>Inners, L. D</creatorcontrib><creatorcontrib>Smith, S. M</creatorcontrib><creatorcontrib>Lane, H. W</creatorcontrib><creatorcontrib>Krauhs, J. M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leach, C. S</au><au>Alfrey, C. P</au><au>Suki, W. N</au><au>Leonard, J. I</au><au>Rambaut, P. C</au><au>Inners, L. D</au><au>Smith, S. M</au><au>Lane, H. W</au><au>Krauhs, J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of body fluid compartments during short-term spaceflight</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>81</volume><issue>1</issue><spage>105</spage><epage>116</epage><pages>105-116</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract><![CDATA[C. S. Leach, C. P. Alfrey, W. N. Suki, J. I. Leonard, P. C. Rambaut, L. D. Inners, S. M. Smith, H. W. Lane and J. M. Krauhs
Biomedical Operations and Research Branch, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas, USA.
The fluid and electrolyte regulation experiment with seven subjects was
designed to describe body fluid, renal, and fluid regulatory hormone
responses during the Spacelab Life Sciences-1 (9 days) and -2 (14 days)
missions. Total body water did not change significantly. Plasma volume (PV;
P < 0.05) and extracellular fluid volume (ECFV; P < 0.10) decreased
21 h after launch, remaining below preflight levels until after landing.
Fluid intake decreased during weightlessness, and glomerular filtration
rate (GFR) increased in the first 2 days and on day 8 (P < 0.05).
Urinary antidiuretic hormone (ADH) excretion increased (P < 0.05) and
fluid excretion decreased early in flight (P < 0.10). Plasma renin
activity (PRA; P < 0.10) and aldosterone (P < 0.05) decreased in the
first few hours after launch; PRA increased 1 wk later (P < 0.05).
During flight, plasma atrial natriuretic peptide concentrations were
consistently lower than preflight means, and urinary cortisol excretion was
usually greater than preflight levels. Acceleration at launch and landing
probably caused increases in ADH and cortisol excretion, and a shift of
fluid from the extracellular to the intracellular compartment would account
for reductions in ECFV. Increased permeability of capillary membranes may
be the most important mechanism causing spaceflight-induced PV reduction,
which is probably maintained by increased GFR and other mechanisms. If the
Gauer-Henry reflex operates during spaceflight, it must be completed within
the first 21 h of flight and be succeeded by establishment of a reduced PV
set point.]]></abstract><cop>United States</cop><pub>Am Physiological Soc</pub><pmid>8828652</pmid><doi>10.1152/jappl.1996.81.1.105</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1996-07, Vol.81 (1), p.105-116 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78379321 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Body Fluid Compartments - physiology Body Water - physiology Body Weight - physiology Diet Female Glomerular Filtration Rate - physiology Humans Kidney Function Tests Leg - anatomy & histology Leg - blood supply Male Middle Aged Plasma Volume - physiology Regional Blood Flow - physiology Space Flight Space life sciences Urodynamics - physiology Water-Electrolyte Balance - physiology Weightlessness - adverse effects Weightlessness Countermeasures |
| title | Regulation of body fluid compartments during short-term spaceflight |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T20%3A59%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20body%20fluid%20compartments%20during%20short-term%20spaceflight&rft.jtitle=Journal%20of%20applied%20physiology%20(1985)&rft.au=Leach,%20C.%20S&rft.date=1996-07-01&rft.volume=81&rft.issue=1&rft.spage=105&rft.epage=116&rft.pages=105-116&rft.issn=8750-7587&rft.eissn=1522-1601&rft_id=info:doi/10.1152/jappl.1996.81.1.105&rft_dat=%3Cproquest_pubme%3E26353965%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=26353965&rft_id=info:pmid/8828652&rfr_iscdi=true |