Cardiovascular and hormonal responses to a meal in hypertrophic cardiomyopathy: A comparison of patients with and without postprandial exacerbation of symptoms
Some patients with hypertrophic cardiomyopathy experience postprandial exacerbation of symptoms. The aim of this study was to determine whether the hemodynamic and/or hormonal responses to a meal differ between patients with and without postprandial symptoms. Ten hypertrophic cardiomyopathy patients...
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| Veröffentlicht in: | Clinical cardiology (Mahwah, N.J.) N.J.), 1996-02, Vol.19 (2), p.129-135 |
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| container_title | Clinical cardiology (Mahwah, N.J.) |
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| creator | Gilligan, David M. Marsonis, Antonios Joshi, Jayshree Bloom, Stephen R. Oakley, Celia M. Nihoyannopoulos, Petros Ghatei, Mohammad A. |
| description | Some patients with hypertrophic cardiomyopathy experience postprandial exacerbation of symptoms. The aim of this study was to determine whether the hemodynamic and/or hormonal responses to a meal differ between patients with and without postprandial symptoms. Ten hypertrophic cardiomyopathy patients with postprandial symptoms, 10 patients without postprandial symptoms, and 10 normal subjects ate a 740 Kcal meal, following which heart rate, blood pressure, and echocardiographic and gastrointestinal hormone changes were compared among the three groups. Heart rate increased (p |
| doi_str_mv | 10.1002/clc.4960190211 |
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The aim of this study was to determine whether the hemodynamic and/or hormonal responses to a meal differ between patients with and without postprandial symptoms. Ten hypertrophic cardiomyopathy patients with postprandial symptoms, 10 patients without postprandial symptoms, and 10 normal subjects ate a 740 Kcal meal, following which heart rate, blood pressure, and echocardiographic and gastrointestinal hormone changes were compared among the three groups. Heart rate increased (p<0.001) and diastolic blood pressure fell (p < 0.001) to a similar degree in the three groups. Left ventricular outflow tract velocity increased (p< 0.01) and some patients had substantial increases in outflow tract pressure gradient; however, this was independent of the presence or absence of postprandial symptoms. The atrial contribution to filling increased in normal subjects and in both groups of hypertrophic cardiomyopathy patients. There was no significant difference in the gastrointestinal hormone changes in the three groups. In summary, there is no evidence for a distinctive hemodynamic or hormonal response to food in hypertrophic cardiomyopathy patients with postprandial symptoms. These symptoms more likely reflect differences in underlying cardiac disease characteristics and severity.</description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.4960190211</identifier><identifier>PMID: 8821423</identifier><identifier>CODEN: CLCADC</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; Blood Flow Velocity ; Blood Pressure ; calcitonin gene‐related peptide ; Cardiology. Vascular system ; Cardiomyopathy, Hypertrophic - diagnostic imaging ; Cardiomyopathy, Hypertrophic - metabolism ; Cardiomyopathy, Hypertrophic - physiopathology ; Eating - physiology ; Echocardiography ; echocardio‐graphy ; Female ; gastrointestinal hormones ; Gastrointestinal Hormones - metabolism ; Heart ; Heart Rate ; Hemodynamics ; Humans ; hypertrophic cardiomyopathy ; Male ; meal ; Medical sciences ; Middle Aged ; Myocarditis. Cardiomyopathies ; Ventricular Function, Left</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 1996-02, Vol.19 (2), p.129-135</ispartof><rights>Copyright © 1996 Wiley Periodicals, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4091-fae5db2a7fba64f5a72f951d55785cc42aebc5d260532b1b7ef8ce80831d2f3a3</citedby><cites>FETCH-LOGICAL-c4091-fae5db2a7fba64f5a72f951d55785cc42aebc5d260532b1b7ef8ce80831d2f3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fclc.4960190211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fclc.4960190211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2985690$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8821423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilligan, David M.</creatorcontrib><creatorcontrib>Marsonis, Antonios</creatorcontrib><creatorcontrib>Joshi, Jayshree</creatorcontrib><creatorcontrib>Bloom, Stephen R.</creatorcontrib><creatorcontrib>Oakley, Celia M.</creatorcontrib><creatorcontrib>Nihoyannopoulos, Petros</creatorcontrib><creatorcontrib>Ghatei, Mohammad A.</creatorcontrib><title>Cardiovascular and hormonal responses to a meal in hypertrophic cardiomyopathy: A comparison of patients with and without postprandial exacerbation of symptoms</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Some patients with hypertrophic cardiomyopathy experience postprandial exacerbation of symptoms. The aim of this study was to determine whether the hemodynamic and/or hormonal responses to a meal differ between patients with and without postprandial symptoms. Ten hypertrophic cardiomyopathy patients with postprandial symptoms, 10 patients without postprandial symptoms, and 10 normal subjects ate a 740 Kcal meal, following which heart rate, blood pressure, and echocardiographic and gastrointestinal hormone changes were compared among the three groups. Heart rate increased (p<0.001) and diastolic blood pressure fell (p < 0.001) to a similar degree in the three groups. Left ventricular outflow tract velocity increased (p< 0.01) and some patients had substantial increases in outflow tract pressure gradient; however, this was independent of the presence or absence of postprandial symptoms. The atrial contribution to filling increased in normal subjects and in both groups of hypertrophic cardiomyopathy patients. There was no significant difference in the gastrointestinal hormone changes in the three groups. In summary, there is no evidence for a distinctive hemodynamic or hormonal response to food in hypertrophic cardiomyopathy patients with postprandial symptoms. These symptoms more likely reflect differences in underlying cardiac disease characteristics and severity.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Blood Pressure</subject><subject>calcitonin gene‐related peptide</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathy, Hypertrophic - diagnostic imaging</subject><subject>Cardiomyopathy, Hypertrophic - metabolism</subject><subject>Cardiomyopathy, Hypertrophic - physiopathology</subject><subject>Eating - physiology</subject><subject>Echocardiography</subject><subject>echocardio‐graphy</subject><subject>Female</subject><subject>gastrointestinal hormones</subject><subject>Gastrointestinal Hormones - metabolism</subject><subject>Heart</subject><subject>Heart Rate</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>hypertrophic cardiomyopathy</subject><subject>Male</subject><subject>meal</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Ventricular Function, Left</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-P1SAUxYnRjM_RrTsTFsZdn0BLC-4mjf-Sl7jRdXNLIcWUgkAd-2n8qjLzXkZ3riDn_s65hIPQS0qOlBD2Vi3q2MiWUEkYpY_QgcqaVaKru8foQGhLKsmEfIqepfS98ESw-gpdCcFow-oD-t1DnKz_CUltC0QM64RnH51fYcFRp-DXpBPOHgN2umh2xfMedMzRh9kqrO79bvcB8ry_wzdYeRcg2uRX7A0ustVrTvjW5vk-_u7it4yDTznEotgSq3-B0nEs8NmWdheyd-k5emJgSfrF5bxG3z68_9p_qk5fPn7ub06VaoiklQHNp5FBZ0ZoG8OhY0ZyOnHeCa5Uw0CPik-sJbxmIx07bYTSgoiaTszUUF-jN-fcEP2PTac8OJuUXhZYtd_S0Im641KKAh7PoIo-pajNEKJ1EPeBkuGukaE0MvxtpBheXZK30enpAb9UUOavL_PSASym_Iiy6QFjUvBWkoLJM3ZrF73_Z-nQn_p_nvAHx_2pjQ</recordid><startdate>199602</startdate><enddate>199602</enddate><creator>Gilligan, David M.</creator><creator>Marsonis, Antonios</creator><creator>Joshi, Jayshree</creator><creator>Bloom, Stephen R.</creator><creator>Oakley, Celia M.</creator><creator>Nihoyannopoulos, Petros</creator><creator>Ghatei, Mohammad A.</creator><general>Wiley Periodicals, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199602</creationdate><title>Cardiovascular and hormonal responses to a meal in hypertrophic cardiomyopathy: A comparison of patients with and without postprandial exacerbation of symptoms</title><author>Gilligan, David M. ; Marsonis, Antonios ; Joshi, Jayshree ; Bloom, Stephen R. ; Oakley, Celia M. ; Nihoyannopoulos, Petros ; Ghatei, Mohammad A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4091-fae5db2a7fba64f5a72f951d55785cc42aebc5d260532b1b7ef8ce80831d2f3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Blood Pressure</topic><topic>calcitonin gene‐related peptide</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathy, Hypertrophic - diagnostic imaging</topic><topic>Cardiomyopathy, Hypertrophic - metabolism</topic><topic>Cardiomyopathy, Hypertrophic - physiopathology</topic><topic>Eating - physiology</topic><topic>Echocardiography</topic><topic>echocardio‐graphy</topic><topic>Female</topic><topic>gastrointestinal hormones</topic><topic>Gastrointestinal Hormones - metabolism</topic><topic>Heart</topic><topic>Heart Rate</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>hypertrophic cardiomyopathy</topic><topic>Male</topic><topic>meal</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilligan, David M.</creatorcontrib><creatorcontrib>Marsonis, Antonios</creatorcontrib><creatorcontrib>Joshi, Jayshree</creatorcontrib><creatorcontrib>Bloom, Stephen R.</creatorcontrib><creatorcontrib>Oakley, Celia M.</creatorcontrib><creatorcontrib>Nihoyannopoulos, Petros</creatorcontrib><creatorcontrib>Ghatei, Mohammad A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilligan, David M.</au><au>Marsonis, Antonios</au><au>Joshi, Jayshree</au><au>Bloom, Stephen R.</au><au>Oakley, Celia M.</au><au>Nihoyannopoulos, Petros</au><au>Ghatei, Mohammad A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular and hormonal responses to a meal in hypertrophic cardiomyopathy: A comparison of patients with and without postprandial exacerbation of symptoms</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>1996-02</date><risdate>1996</risdate><volume>19</volume><issue>2</issue><spage>129</spage><epage>135</epage><pages>129-135</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><coden>CLCADC</coden><abstract>Some patients with hypertrophic cardiomyopathy experience postprandial exacerbation of symptoms. The aim of this study was to determine whether the hemodynamic and/or hormonal responses to a meal differ between patients with and without postprandial symptoms. Ten hypertrophic cardiomyopathy patients with postprandial symptoms, 10 patients without postprandial symptoms, and 10 normal subjects ate a 740 Kcal meal, following which heart rate, blood pressure, and echocardiographic and gastrointestinal hormone changes were compared among the three groups. Heart rate increased (p<0.001) and diastolic blood pressure fell (p < 0.001) to a similar degree in the three groups. Left ventricular outflow tract velocity increased (p< 0.01) and some patients had substantial increases in outflow tract pressure gradient; however, this was independent of the presence or absence of postprandial symptoms. The atrial contribution to filling increased in normal subjects and in both groups of hypertrophic cardiomyopathy patients. There was no significant difference in the gastrointestinal hormone changes in the three groups. In summary, there is no evidence for a distinctive hemodynamic or hormonal response to food in hypertrophic cardiomyopathy patients with postprandial symptoms. These symptoms more likely reflect differences in underlying cardiac disease characteristics and severity.</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>8821423</pmid><doi>10.1002/clc.4960190211</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Analysis of Variance Biological and medical sciences Blood Flow Velocity Blood Pressure calcitonin gene‐related peptide Cardiology. Vascular system Cardiomyopathy, Hypertrophic - diagnostic imaging Cardiomyopathy, Hypertrophic - metabolism Cardiomyopathy, Hypertrophic - physiopathology Eating - physiology Echocardiography echocardio‐graphy Female gastrointestinal hormones Gastrointestinal Hormones - metabolism Heart Heart Rate Hemodynamics Humans hypertrophic cardiomyopathy Male meal Medical sciences Middle Aged Myocarditis. Cardiomyopathies Ventricular Function, Left |
| title | Cardiovascular and hormonal responses to a meal in hypertrophic cardiomyopathy: A comparison of patients with and without postprandial exacerbation of symptoms |
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