Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord
Intrathecal (i.t.) administration of morphine in the spinal subarachnoid space of mice produced a severe hindlimb scratching followed by biting and licking. The onset of the scratching behaviour was observed 60–70 s after i.t. injection of morphine (60 and 90 nmol), and had a duration of 3–4 min. Th...
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| Veröffentlicht in: | Brain research 1996-06, Vol.724 (2), p.213-221 |
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| creator | Sakurada, Tsukasa Wako, Kenji Sakurada, Chikai Manome, Yoichi Tan-no, Koichi Sakurada, Shinobu Kisara, Kensuke |
| description | Intrathecal (i.t.) administration of morphine in the spinal subarachnoid space of mice produced a severe hindlimb scratching followed by biting and licking. The onset of the scratching behaviour was observed 60–70 s after i.t. injection of morphine (60 and 90 nmol), and had a duration of 3–4 min. The morphine-induced behaviour was increased additively by i.t. co-administration of substance P (SP). This characteristic behavioural response was inhibited dose-dependently by i.t. co-administration of the tachykinin NK-1 receptor antagonists, sendide and CP-96,345. Significant antagonistic effects of SP (1–7), a putative antagonist for NK-1 receptors and [
d-Phe
7,
d-His
9jSP (6–11), a selective antagonist for SP receptors, were observed against the morphine-induced behaviour. Pretreatment with i.t. SP antiserum and i.t. capsaicin resulted in reduction of the response to morphine. I.t. administration of somatostatin (SOM) antiserum, cysteamine, a relatively selective depletor of SOM and cyclo-SOM, a SOM receptor antagonist, produced no inhibitory effect on the morphine-induced behaviour. These results demonstrate that a spinal system of neurones containing SP may be involved in elicitation of the behavioural episode following i.t. injection of morphine in mice. |
| doi_str_mv | 10.1016/0006-8993(96)00319-8 |
| format | Article |
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d-Phe
7,
d-His
9jSP (6–11), a selective antagonist for SP receptors, were observed against the morphine-induced behaviour. Pretreatment with i.t. SP antiserum and i.t. capsaicin resulted in reduction of the response to morphine. I.t. administration of somatostatin (SOM) antiserum, cysteamine, a relatively selective depletor of SOM and cyclo-SOM, a SOM receptor antagonist, produced no inhibitory effect on the morphine-induced behaviour. These results demonstrate that a spinal system of neurones containing SP may be involved in elicitation of the behavioural episode following i.t. injection of morphine in mice.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(96)00319-8</identifier><identifier>PMID: 8828571</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject><![CDATA[Animals ; Behavior, Animal - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Capsaicin - administration & dosage ; Capsaicin - pharmacology ; Cystamine - administration & dosage ; Cystamine - pharmacology ; Dose-Response Relationship, Drug ; Enzyme Inhibitors - administration & dosage ; Enzyme Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hormone Antagonists - administration & dosage ; Hormone Antagonists - pharmacology ; Injections, Spinal ; Intrathecal injection ; Male ; Mice ; Mice, Inbred Strains ; Morphine ; Morphine - administration & dosage ; Morphine - antagonists & inhibitors ; Morphine - pharmacology ; Narcotic Antagonists - administration & dosage ; Narcotic Antagonists - pharmacology ; Narcotics - administration & dosage ; Narcotics - pharmacology ; Neurotransmission and behavior ; NK-1 receptor antagonist ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Scratch reflex ; Somatostatin - administration & dosage ; Somatostatin - antagonists & inhibitors ; Somatostatin - pharmacology ; Spinal cord ; Spinal Cord - physiology ; Substance P - analogs & derivatives ; Substance P - pharmacology ; Substance P - physiology ; Tachykinins - administration & dosage ; Tachykinins - antagonists & inhibitors]]></subject><ispartof>Brain research, 1996-06, Vol.724 (2), p.213-221</ispartof><rights>1996 Elsevier Science B.V. All rights reserved</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-b63cd3c2a33bfa42380a0d2a5105d88600ec20a4c20c2df8bff43920f46efb5f3</citedby><cites>FETCH-LOGICAL-c417t-b63cd3c2a33bfa42380a0d2a5105d88600ec20a4c20c2df8bff43920f46efb5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(96)00319-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3128822$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8828571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakurada, Tsukasa</creatorcontrib><creatorcontrib>Wako, Kenji</creatorcontrib><creatorcontrib>Sakurada, Chikai</creatorcontrib><creatorcontrib>Manome, Yoichi</creatorcontrib><creatorcontrib>Tan-no, Koichi</creatorcontrib><creatorcontrib>Sakurada, Shinobu</creatorcontrib><creatorcontrib>Kisara, Kensuke</creatorcontrib><title>Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Intrathecal (i.t.) administration of morphine in the spinal subarachnoid space of mice produced a severe hindlimb scratching followed by biting and licking. The onset of the scratching behaviour was observed 60–70 s after i.t. injection of morphine (60 and 90 nmol), and had a duration of 3–4 min. The morphine-induced behaviour was increased additively by i.t. co-administration of substance P (SP). This characteristic behavioural response was inhibited dose-dependently by i.t. co-administration of the tachykinin NK-1 receptor antagonists, sendide and CP-96,345. Significant antagonistic effects of SP (1–7), a putative antagonist for NK-1 receptors and [
d-Phe
7,
d-His
9jSP (6–11), a selective antagonist for SP receptors, were observed against the morphine-induced behaviour. Pretreatment with i.t. SP antiserum and i.t. capsaicin resulted in reduction of the response to morphine. I.t. administration of somatostatin (SOM) antiserum, cysteamine, a relatively selective depletor of SOM and cyclo-SOM, a SOM receptor antagonist, produced no inhibitory effect on the morphine-induced behaviour. These results demonstrate that a spinal system of neurones containing SP may be involved in elicitation of the behavioural episode following i.t. injection of morphine in mice.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Capsaicin - administration & dosage</subject><subject>Capsaicin - pharmacology</subject><subject>Cystamine - administration & dosage</subject><subject>Cystamine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Inhibitors - administration & dosage</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone Antagonists - administration & dosage</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Injections, Spinal</subject><subject>Intrathecal injection</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - antagonists & inhibitors</subject><subject>Morphine - pharmacology</subject><subject>Narcotic Antagonists - administration & dosage</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Narcotics - administration & dosage</subject><subject>Narcotics - pharmacology</subject><subject>Neurotransmission and behavior</subject><subject>NK-1 receptor antagonist</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Scratch reflex</subject><subject>Somatostatin - administration & dosage</subject><subject>Somatostatin - antagonists & inhibitors</subject><subject>Somatostatin - pharmacology</subject><subject>Spinal cord</subject><subject>Spinal Cord - physiology</subject><subject>Substance P - analogs & derivatives</subject><subject>Substance P - pharmacology</subject><subject>Substance P - physiology</subject><subject>Tachykinins - administration & dosage</subject><subject>Tachykinins - antagonists & inhibitors</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoYzv6DxSyEBkXpXnUI-VCkMEXDCio65BKbqxodaUmqSroPzG_2Vt200vdJITzncvNOYQ85ewVZ7x-zRirC9W28qqtXzImeVuoe2THVSOKWpTsPtmdkYfkUc6_8Cllyy7IhVJCVQ3fkbtvUxjNMByKPbhgZnC0g96sIS7JDDRBnuKYIVNY4-9NPNAwzsnMPVjU-_CzL1zMQPcxTX0Y4Q2dYs6hGwDBNQ4r7GGcafQ0L12ezWiBfkWJ4gQ0LWjNf1egNib3mDzwZsjw5HRfkh8f3n-__lTcfPn4-frdTWFL3sxFV0vrpBVGys6bUkjFDHPCVJxVTqmaMbCCmRIPK5xXnfelbAXzZQ2-q7y8JC-Oc6cUbxfIs96HbGEYzAi4k26UbGTdyP-CvKqUVGWNYHkEbcL_J_B6SmFv0kFzpre-9FaG3srQ7fbAvrRC27PT_KXDBs6mU0GoPz_pJmPgPmGAIZ8xyQWSArG3RwwwtDVA0tkGwKxdSGBn7WL49x5_AJ_EtHc</recordid><startdate>19960617</startdate><enddate>19960617</enddate><creator>Sakurada, Tsukasa</creator><creator>Wako, Kenji</creator><creator>Sakurada, Chikai</creator><creator>Manome, Yoichi</creator><creator>Tan-no, Koichi</creator><creator>Sakurada, Shinobu</creator><creator>Kisara, Kensuke</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19960617</creationdate><title>Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord</title><author>Sakurada, Tsukasa ; Wako, Kenji ; Sakurada, Chikai ; Manome, Yoichi ; Tan-no, Koichi ; Sakurada, Shinobu ; Kisara, Kensuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-b63cd3c2a33bfa42380a0d2a5105d88600ec20a4c20c2df8bff43920f46efb5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Capsaicin - administration & dosage</topic><topic>Capsaicin - pharmacology</topic><topic>Cystamine - administration & dosage</topic><topic>Cystamine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Inhibitors - administration & dosage</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone Antagonists - administration & dosage</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Injections, Spinal</topic><topic>Intrathecal injection</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - antagonists & inhibitors</topic><topic>Morphine - pharmacology</topic><topic>Narcotic Antagonists - administration & dosage</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Narcotics - administration & dosage</topic><topic>Narcotics - pharmacology</topic><topic>Neurotransmission and behavior</topic><topic>NK-1 receptor antagonist</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Scratch reflex</topic><topic>Somatostatin - administration & dosage</topic><topic>Somatostatin - antagonists & inhibitors</topic><topic>Somatostatin - pharmacology</topic><topic>Spinal cord</topic><topic>Spinal Cord - physiology</topic><topic>Substance P - analogs & derivatives</topic><topic>Substance P - pharmacology</topic><topic>Substance P - physiology</topic><topic>Tachykinins - administration & dosage</topic><topic>Tachykinins - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakurada, Tsukasa</creatorcontrib><creatorcontrib>Wako, Kenji</creatorcontrib><creatorcontrib>Sakurada, Chikai</creatorcontrib><creatorcontrib>Manome, Yoichi</creatorcontrib><creatorcontrib>Tan-no, Koichi</creatorcontrib><creatorcontrib>Sakurada, Shinobu</creatorcontrib><creatorcontrib>Kisara, Kensuke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakurada, Tsukasa</au><au>Wako, Kenji</au><au>Sakurada, Chikai</au><au>Manome, Yoichi</au><au>Tan-no, Koichi</au><au>Sakurada, Shinobu</au><au>Kisara, Kensuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1996-06-17</date><risdate>1996</risdate><volume>724</volume><issue>2</issue><spage>213</spage><epage>221</epage><pages>213-221</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Intrathecal (i.t.) administration of morphine in the spinal subarachnoid space of mice produced a severe hindlimb scratching followed by biting and licking. The onset of the scratching behaviour was observed 60–70 s after i.t. injection of morphine (60 and 90 nmol), and had a duration of 3–4 min. The morphine-induced behaviour was increased additively by i.t. co-administration of substance P (SP). This characteristic behavioural response was inhibited dose-dependently by i.t. co-administration of the tachykinin NK-1 receptor antagonists, sendide and CP-96,345. Significant antagonistic effects of SP (1–7), a putative antagonist for NK-1 receptors and [
d-Phe
7,
d-His
9jSP (6–11), a selective antagonist for SP receptors, were observed against the morphine-induced behaviour. Pretreatment with i.t. SP antiserum and i.t. capsaicin resulted in reduction of the response to morphine. I.t. administration of somatostatin (SOM) antiserum, cysteamine, a relatively selective depletor of SOM and cyclo-SOM, a SOM receptor antagonist, produced no inhibitory effect on the morphine-induced behaviour. These results demonstrate that a spinal system of neurones containing SP may be involved in elicitation of the behavioural episode following i.t. injection of morphine in mice.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8828571</pmid><doi>10.1016/0006-8993(96)00319-8</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Brain research, 1996-06, Vol.724 (2), p.213-221 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Capsaicin - administration & dosage Capsaicin - pharmacology Cystamine - administration & dosage Cystamine - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hormone Antagonists - administration & dosage Hormone Antagonists - pharmacology Injections, Spinal Intrathecal injection Male Mice Mice, Inbred Strains Morphine Morphine - administration & dosage Morphine - antagonists & inhibitors Morphine - pharmacology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology Narcotics - administration & dosage Narcotics - pharmacology Neurotransmission and behavior NK-1 receptor antagonist Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Scratch reflex Somatostatin - administration & dosage Somatostatin - antagonists & inhibitors Somatostatin - pharmacology Spinal cord Spinal Cord - physiology Substance P - analogs & derivatives Substance P - pharmacology Substance P - physiology Tachykinins - administration & dosage Tachykinins - antagonists & inhibitors |
| title | Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord |
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