Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats
Aging in man is associated with alterations in food intake (FI) and body weight (BW). To establish a model of age-related alterations in FI and BW regulation, FI and BW were determined in young (3-month-old), middle-aged (12-month-old), and old (24-month-old) male Brown Norway rats during ad libitum...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 1996-10, Vol.137 (10), p.4460-4467 |
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| creator | Gruenewald, D A Marck, B T Matsumoto, A M |
| description | Aging in man is associated with alterations in food intake (FI) and body weight (BW). To establish a model of age-related alterations in FI and BW regulation, FI and BW were determined in young (3-month-old), middle-aged (12-month-old), and old (24-month-old) male Brown Norway rats during ad libitum feeding and after 72 h of fasting. FI was reduced with aging both during ad libitum feeding and after fasting. With fasting, young rats lost more BW than older rats, but regained BW more rapidly during refeeding. To determine whether age-related impairments in FI and BW regulation are mediated by neuropeptide Y (NPY), a potent stimulator of FI, we compared arcuate nucleus prepro-NPY (ppNPY) messenger RNA (mRNA) by in situ hybridization in fasted and ad libitum-fed (fed) young, middle-aged, and old rats. ppNPY mRNA declined with aging in both fed and fasted rats. Although ppNPY mRNA increased with fasting in all age groups, this response was attenuated with aging. In conclusion, impaired FI and BW recovery after fasting is associated with reduced NPY responsiveness to fasting in aging rats. Impaired activation of the hypothalamic NPY pathway may, therefore, contribute to age-related alterations in FI and BW regulation. |
| doi_str_mv | 10.1210/en.137.10.4460 |
| format | Article |
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To establish a model of age-related alterations in FI and BW regulation, FI and BW were determined in young (3-month-old), middle-aged (12-month-old), and old (24-month-old) male Brown Norway rats during ad libitum feeding and after 72 h of fasting. FI was reduced with aging both during ad libitum feeding and after fasting. With fasting, young rats lost more BW than older rats, but regained BW more rapidly during refeeding. To determine whether age-related impairments in FI and BW regulation are mediated by neuropeptide Y (NPY), a potent stimulator of FI, we compared arcuate nucleus prepro-NPY (ppNPY) messenger RNA (mRNA) by in situ hybridization in fasted and ad libitum-fed (fed) young, middle-aged, and old rats. ppNPY mRNA declined with aging in both fed and fasted rats. Although ppNPY mRNA increased with fasting in all age groups, this response was attenuated with aging. In conclusion, impaired FI and BW recovery after fasting is associated with reduced NPY responsiveness to fasting in aging rats. Impaired activation of the hypothalamic NPY pathway may, therefore, contribute to age-related alterations in FI and BW regulation.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.137.10.4460</identifier><identifier>PMID: 8828508</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Aging ; Aging (artificial) ; Aging - physiology ; Animals ; Arcuate nucleus ; Arcuate Nucleus of Hypothalamus - metabolism ; Blood Glucose - analysis ; Body Weight ; Chronology ; Eating ; Fasting ; Food intake ; Gene Expression ; Hybridization ; Hypothalamus ; Insulin - blood ; Male ; Males ; Middle age ; Neuropeptide Y ; Neuropeptide Y - genetics ; Neuropeptides ; Protein Precursors - genetics ; Rats ; Rats, Inbred BN ; RNA, Messenger - metabolism ; Stimulators ; Y gene</subject><ispartof>Endocrinology (Philadelphia), 1996-10, Vol.137 (10), p.4460-4467</ispartof><rights>Copyright © 1996 by The Endocrine Society 1996</rights><rights>Copyright © 1996 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-570b48267741e2108461fecc81ca6d73a3bfbfdf0edb0874c029c1e80cf0ee183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8828508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruenewald, D A</creatorcontrib><creatorcontrib>Marck, B T</creatorcontrib><creatorcontrib>Matsumoto, A M</creatorcontrib><title>Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Aging in man is associated with alterations in food intake (FI) and body weight (BW). To establish a model of age-related alterations in FI and BW regulation, FI and BW were determined in young (3-month-old), middle-aged (12-month-old), and old (24-month-old) male Brown Norway rats during ad libitum feeding and after 72 h of fasting. FI was reduced with aging both during ad libitum feeding and after fasting. With fasting, young rats lost more BW than older rats, but regained BW more rapidly during refeeding. To determine whether age-related impairments in FI and BW regulation are mediated by neuropeptide Y (NPY), a potent stimulator of FI, we compared arcuate nucleus prepro-NPY (ppNPY) messenger RNA (mRNA) by in situ hybridization in fasted and ad libitum-fed (fed) young, middle-aged, and old rats. ppNPY mRNA declined with aging in both fed and fasted rats. Although ppNPY mRNA increased with fasting in all age groups, this response was attenuated with aging. In conclusion, impaired FI and BW recovery after fasting is associated with reduced NPY responsiveness to fasting in aging rats. Impaired activation of the hypothalamic NPY pathway may, therefore, contribute to age-related alterations in FI and BW regulation.</description><subject>Aging</subject><subject>Aging (artificial)</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Arcuate nucleus</subject><subject>Arcuate Nucleus of Hypothalamus - metabolism</subject><subject>Blood Glucose - analysis</subject><subject>Body Weight</subject><subject>Chronology</subject><subject>Eating</subject><subject>Fasting</subject><subject>Food intake</subject><subject>Gene Expression</subject><subject>Hybridization</subject><subject>Hypothalamus</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Males</subject><subject>Middle age</subject><subject>Neuropeptide Y</subject><subject>Neuropeptide Y - genetics</subject><subject>Neuropeptides</subject><subject>Protein Precursors - genetics</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>RNA, Messenger - metabolism</subject><subject>Stimulators</subject><subject>Y gene</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFLwzAYxYMoc06v3oSAIHjoTJq0yY4ynApDL3rwVNL06-jckpqkzPnXm27Dg6fkfe_H40seQpeUjGlKyR2YMWViHCXnOTlCQzrhWSKoIMdoSAhliUhTcYrOvF9GyTlnAzSQMpUZkUP0M1M-NGaRNKbqNFS4MdqB8uDjDdfW9pOgPgErU2EDnbMttKGpAH_gBRjA8N068L6xBisXsRDAdCrsorBaxGy8VivApbMbg1-s26gtdir4c3RSq5WHi8M5Qu-zh7fpUzJ_fXye3s8TzTIakkyQkss0F4JTiC-WPKc1aC2pVnklmGJlXdZVTaAqiRRck3SiKUii4wioZCN0s89tnf3qwIdi3XgNq5UyYDtfCMlEmu_A63_g0nbOxN0KRhnhkuWERerqQHXlGqqidc1auW1x-NLo3-5927V_JiVF31YBpoht9bJvi_0C21qGDw</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Gruenewald, D A</creator><creator>Marck, B T</creator><creator>Matsumoto, A M</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19961001</creationdate><title>Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats</title><author>Gruenewald, D A ; Marck, B T ; Matsumoto, A M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-570b48267741e2108461fecc81ca6d73a3bfbfdf0edb0874c029c1e80cf0ee183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aging</topic><topic>Aging (artificial)</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Arcuate nucleus</topic><topic>Arcuate Nucleus of Hypothalamus - metabolism</topic><topic>Blood Glucose - analysis</topic><topic>Body Weight</topic><topic>Chronology</topic><topic>Eating</topic><topic>Fasting</topic><topic>Food intake</topic><topic>Gene Expression</topic><topic>Hybridization</topic><topic>Hypothalamus</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Males</topic><topic>Middle age</topic><topic>Neuropeptide Y</topic><topic>Neuropeptide Y - genetics</topic><topic>Neuropeptides</topic><topic>Protein Precursors - genetics</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>RNA, Messenger - metabolism</topic><topic>Stimulators</topic><topic>Y gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruenewald, D A</creatorcontrib><creatorcontrib>Marck, B T</creatorcontrib><creatorcontrib>Matsumoto, A M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruenewald, D A</au><au>Marck, B T</au><au>Matsumoto, A M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>137</volume><issue>10</issue><spage>4460</spage><epage>4467</epage><pages>4460-4467</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><abstract>Aging in man is associated with alterations in food intake (FI) and body weight (BW). To establish a model of age-related alterations in FI and BW regulation, FI and BW were determined in young (3-month-old), middle-aged (12-month-old), and old (24-month-old) male Brown Norway rats during ad libitum feeding and after 72 h of fasting. FI was reduced with aging both during ad libitum feeding and after fasting. With fasting, young rats lost more BW than older rats, but regained BW more rapidly during refeeding. To determine whether age-related impairments in FI and BW regulation are mediated by neuropeptide Y (NPY), a potent stimulator of FI, we compared arcuate nucleus prepro-NPY (ppNPY) messenger RNA (mRNA) by in situ hybridization in fasted and ad libitum-fed (fed) young, middle-aged, and old rats. ppNPY mRNA declined with aging in both fed and fasted rats. Although ppNPY mRNA increased with fasting in all age groups, this response was attenuated with aging. In conclusion, impaired FI and BW recovery after fasting is associated with reduced NPY responsiveness to fasting in aging rats. Impaired activation of the hypothalamic NPY pathway may, therefore, contribute to age-related alterations in FI and BW regulation.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>8828508</pmid><doi>10.1210/en.137.10.4460</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford Journals Online; EZB Electronic Journals Library |
| subjects | Aging Aging (artificial) Aging - physiology Animals Arcuate nucleus Arcuate Nucleus of Hypothalamus - metabolism Blood Glucose - analysis Body Weight Chronology Eating Fasting Food intake Gene Expression Hybridization Hypothalamus Insulin - blood Male Males Middle age Neuropeptide Y Neuropeptide Y - genetics Neuropeptides Protein Precursors - genetics Rats Rats, Inbred BN RNA, Messenger - metabolism Stimulators Y gene |
| title | Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats |
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